152 research outputs found
Motivational dynamics of German Salafist jihadists: A multi-methodical in-depth study of three paradigmatic cases
Individuals belonging to terrorist organizations accept and often use violence as an instrument of their strategies to achieve their goals. The present study focuses on the motivational dynamics of three contrastively selected paradigmatic cases of extremists that grew up in Germany, joined and supported terrorist organizations abroad, and later disengaged and distanced themselves from the jihadist ideology. An innovative multi-methodical approach was applied to the interviews that combines a biographical reconstruction of the lived experiences with a psychoanalytically informed interpretation of the narratives. First, the biographical trajectories were analyzed on the manifest level: How have the former terrorists experienced their own pathways? What were relevant factors for their engagement in and disengagement from terrorism? Second, to gain a deeper understanding of the unconscious motivational dynamics for involvement in terrorism, key sequences of the narrative interviews were interpreted scenically in a psychoanalytical interpretation group: How did the interviewees express their lived experiences (and why in this particular way)? What latent meanings can be extrapolated that provide deep insights into the motivational backgrounds of their decisions? Based on the results of the triangulation process, characterizing structural hypotheses about case dynamics including protective and risk factors are presented and implications for prevention and intervention approaches are given
Implementation Of Good Governance And “Mapalus” Cultural Values Of Minahasa Tribe In Village Financial Management
Abstract – The implementation of regional autonomy provides an opportunity for local governments, including village governments to regulate their own government according to village characteristics. The Minahasa tribal community has a high cultural value, namely "Mapalus". "Mapalus" is a form of cooperative activity in social life that upholds harmony and peace to achieve mutual prosperity. However, if it is not supported by a government based on the principles of Good Governance, then the cultural value of "Mapalus" will actually harm the community. The purpose of this study is to explore and analyze the role of Good Governance and the cultural value of “Mapalus” in village financial management. This research was conducted for four months in Kolongan Village, Talawaan District, North Minahasa Regency, North Sulawesi Province. The results of the study indicate that in implementing Good Governance, the government must involve the community in the regional financial management process, starting from the planning, implementation, reporting, and accountability stages. Then, the community must maintain the cultural value of "Mapalus" while actively participating in government administration activities through giving aspirations, supervising, and daring to criticize the government to create a clean government and prevent misuse of village funds
A simulation study on spatial and time resolution for a cost-effective positron emission particle tracking system
This work is the second part of a simulation study investigating the
processing of densely packed and moving granular assemblies by positron
emission particle tracking (PEPT). Since medical PET scanners commonly used for
PEPT are very expensive, a PET-like detector system based on cost-effective
organic plastic scintillator bars is being developed and tested for its
capabilities. In this context, the spatial resolution of a resting positron
source, a source moving on a freely designed model path, and a particle motion
given by a DEM (Discrete Element Method) simulation is studied using Monte
Carlo simulations and the software toolkit Geant4. This not only extended the
simulation and reconstruction to a moving source but also significantly
improved the spatial resolution compared to previous work by adding
oversampling and iteration to the reconstruction algorithm. Furthermore, in the
case of a source following a trajectory developed from DEM simulations, a very
good resolution of about 1 mm in all three directions and an average
three-dimensional deviation between simulated and reconstructed events of 2.3
mm could be determined. Thus, the resolution for a realistic particle motion
within the generic grate system (which is the test rig for further experimental
studies) is well below the smallest particle size. The simulation of the
dependence of the reconstruction accuracy on tracer particle location revealed
a nearly constant efficiency within the entire detector system, which
demonstrates that boundary effects can be neglected.Comment: Published in Particuology 88 (2024) 312-322. This manuscript version
is made available under the CC-BY-NC-ND 4.0 licens
Development of the front-end electronics for a cost-effective PET-like detector system
Most detector systems used for positron emission particle tracking (PEPT) are
very expensive due to the use of inorganic plastic scintillators combined with
a high number of readout electronic channels. This work aims to reduce the
overall cost of a PEPT-capable detector system by using large and
cost-effective plastic scintillators and developing custom 2 x 2 silicon
photomultiplier (SiPM) arrays, preamplifiers, and discriminators. The use of
long (20 mm x 20 mm x 1000 mm) plastic scintillator bars read out with
photodetectors only at their respective ends allows an overall smaller number
of photodetectors and associated readout electronics, which in turn reduces the
overall cost of the system. In addition, the development of a custom SiPM array
and preamplifier allows a free selection of interconnection and readout, as
most commercial producers only offer specific types of interconnections and
therefore lack other connections such as serial or hybrid. Thus, several common
circuit types for SiPMs and preamplifiers were tested and compared in this
work, and it was found that a serial connection implemented in a hybrid
interconnection for the SiPMs and an inverting preamplifier based on a
high-frequency operational amplifier provided the best results for the proposed
detector system. Measured with a Na-22 source, the combination of SiPM array
and preamplifier led to a rise time of 3.7 ns and a signal amplitude of 175 mV.Comment: Published in Nuclear Instruments and Methods in Physics Research A
1057 (2023) 168767. This manuscript version is made available under the
CC-BY-NC-ND 4.0 licens
Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen.
Funder: Raymond and Beverly Sackler FoundationFunder: Isaac Newton TrustFunder: Newnham College, University of CambridgeFunder: Medical Research CouncilMutation rates vary both within and between bacterial species, and understanding what drives this variation is essential for understanding the evolutionary dynamics of bacterial populations. In this study, we investigate two factors that are predicted to influence the mutation rate: ecology and genome size. We conducted mutation accumulation experiments on eight strains of the emerging zoonotic pathogen Streptococcus suis. Natural variation within this species allows us to compare tonsil carriage and invasive disease isolates, from both more and less pathogenic populations, with a wide range of genome sizes. We find that invasive disease isolates have repeatedly evolved mutation rates that are higher than those of closely related carriage isolates, regardless of variation in genome size. Independent of this variation in overall rate, we also observe a stronger bias towards G/C to A/T mutations in isolates from more pathogenic populations, whose genomes tend to be smaller and more AT-rich. Our results suggest that ecology is a stronger correlate of mutation rate than genome size over these timescales, and that transitions to invasive disease are consistently accompanied by rapid increases in mutation rate. These results shed light on the impact that ecology can have on the adaptive potential of bacterial pathogens
The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs
The expansion and intensification of livestock production is predicted to promote the emergence of pathogens. As pathogens sometimes jump between species, this can affect the health of humans as well as livestock. Here, we investigate how livestock microbiota can act as a source of these emerging pathogens through analysis of Streptococcus suis, a ubiquitous component of the respiratory microbiota of pigs that is also a major cause of disease on pig farms and an important zoonotic pathogen. Combining molecular dating, phylogeography, and comparative genomic analyses of a large collection of isolates, we find that several pathogenic lineages of S. suis emerged in the 19th and 20th centuries, during an early period of growth in pig farming. These lineages have since spread between countries and continents, mirroring trade in live pigs. They are distinguished by the presence of three genomic islands with putative roles in metabolism and cell adhesion, and an ongoing reduction in genome size, which may reflect their recent shift to a more pathogenic ecology. Reconstructions of the evolutionary histories of these islands reveal constraints on pathogen emergence that could inform control strategies, with pathogenic lineages consistently emerging from one subpopulation of S. suis and acquiring genes through horizontal transfer from other pathogenic lineages. These results shed light on the capacity of the microbiota to rapidly evolve to exploit changes in their host population and suggest that the impact of changes in farming on the pathogenicity and zoonotic potential of S. suis is yet to be fully realized
The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs
The expansion and intensification of livestock production is predicted to promote the
emergence of pathogens. As pathogens sometimes jump between species, this can affect
the health of humans as well as livestock. Here, we investigate how livestock microbiota
can act as a source of these emerging pathogens through analysis of Streptococcus suis, a
ubiquitous component of the respiratory microbiota of pigs that is also a major cause of
disease on pig farms and an important zoonotic pathogen. Combining molecular dating,
phylogeography, and comparative genomic analyses of a large collection of isolates, we
find that several pathogenic lineages of S. suis emerged in the 19th and 20th centuries,
during an early period of growth in pig farming. These lineages have since spread between
countries and continents, mirroring trade in live pigs. They are distinguished by the
presence of three genomic islands with putative roles in metabolism and cell adhesion,
and an ongoing reduction in genome size, which may reflect their recent shift to a more
pathogenic ecology. Reconstructions of the evolutionary histories of these islands reveal
constraints on pathogen emergence that could inform control strategies, with pathogenic lineages consistently emerging from one subpopulation of S. suis and acquiring
genes through horizontal transfer from other pathogenic lineages. These results shed
light on the capacity of the microbiota to rapidly evolve to exploit changes in their host
population and suggest that the impact of changes in farming on the pathogenicity and
zoonotic potential of S. suis is yet to be fully realized.This work was primarily funded by an EU Horizon 2020 grant “PIGSs” (727966) and a ZELS BBSRC award “Myanmar Pigs Partnership (MPP)” (BB/L018934/1). G.G.R.M., E.L.M., and L.A.W. were supported by a Sir Henry Dale Fellowship to L.A.W. jointly funded by the Wellcome Trust and the Royal Society (109385/Z/15/Z). N.H. was supported by a Challenge grant from the Royal Society (CH16011) and an Isaac Newton Trust Research Grant [17.24(u)]. G.G.R.M. was also supported by a Research Fellowship at Newnham College. S.B. is supported by the Medical Research Council (MR/V032836/1). PIC North America provided part of the funds for the sequencing of the isolates from the USA. A.J.B. and M.M. were funded by Medical Research Council and Biotechnology and Biological Sciences Research Council studentships respectively, and M.M. was co-funded by the Raymond and Beverly Sackler Fund. We would like to acknowledge Susanna Williamson at the APHA for providing samples, Oscar Cabezón for sampling of the wild boar population in Spain, Mark O’Dea for access to sequence data from Australian isolates, the PIGSs and MPP consortiums for providing samples and helpful discussions, Julian Parkhill and John Welch for helpful discussions, and two anonymous reviewers for their valuable suggestions for improving the manuscript. This research was funded in whole or in part by the Wellcome Trust. For the purpose of Open Access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript (AAM) version arising from this submission.info:eu-repo/semantics/publishedVersio
Learning together for and with the Martuwarra Fitzroy River
Co-production across scientific and Indigenous knowledge systems has become a cornerstone of research to enhance knowledge, practice, ethics, and foster sustainability transformations. However, the profound differences in world views and the complex and contested histories of nation-state colonisation on Indigenous territories, highlight both opportunities and risks for Indigenous people when engaging with knowledge co-production. This paper investigates the conditions under which knowledge co-production can lead to improved Indigenous adaptive environmental planning and management among remote land-attached Indigenous peoples through a case study with ten Traditional Owner groups in the Martuwarra (Fitzroy River) Catchment in Western Australia’s Kimberley region. The research team built a 3D map of the river and used it, together with an interactive table-top projector, to bring together both scientific and Indigenous spatial knowledge. Participatory influence mapping, aligned with Traditional Owner priorities to achieve cultural governance and management planning goals set out in the Fitzroy River Declaration, investigated power relations. An analytical framework, examining underlying mechanisms of social learning, knowledge promotion and enhancing influence, based on different theories of change, was applied to unpack the immediate outcomes from these activities. The analysis identified that knowledge co-production activities improved the accessibility of the knowledge, the experiences of the knowledge users, strengthened collective identity and partnerships, and strengthened Indigenous-led institutions. The focus on cultural governance and management planning goals in the Fitzroy River Declaration enabled the activities to directly affect key drivers of Indigenous adaptive environmental planning and management—the Indigenous-led institutions. The nation-state arrangements also gave some support to local learning and decision-making through a key Indigenous institution, Martuwarra Fitzroy River Council. Knowledge co-production with remote land-attached Indigenous peoples can improve adaptive environmental planning and management where it fosters learning together, is grounded in the Indigenous-led institutions and addresses their priorities
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