Anomalous pressure effect on the magnetic ordering in multiferroic BiMnO3

We report the magnetic field dependent dc magnetization and the pressure-dependent (pmax ~ 16 kbar) ac susceptibilities Xp(T) on both powder and bulk multiferroic BiMnO3 samples, synthesized in different batches under high pressure. A clear ferromagnetic (FM) transition is observed at TC ~ 100 K, and increases with magnetic field. The magnetic hysteresis behavior is similar to that of a soft ferromagnet. Ac susceptibility data indicate that both the FM peak and its temperature (TC) decrease simultaneously with increasing pressure. Interestingly, above a certain pressure (9 ~ 11 kbar), another peak appears at Tp ~ 93 K, which also decreases with increasing pressure, with both these peaks persisting over some intermediate pressure range (9 ~ 13 kbar). The FM peak disappears with further application of pressure; however, the second peak survives until present pressure limit (pmax ~ 16 kbar). These features are considered to originate from the complex interplay of the magnetic and orbital structure of BiMnO3 being affected by pressure.Comment: 4 pages,4 figures, publised in Physical Review B 78, 092404/200

Risk and Value in Privately Financed Health care Projects

An empirical study is presented to investigate the risk factors affecting the value for money that can be obtained from using the public-private partnership delivery system to develop social facility projects. Based on a model describing the main risks affecting a project, a linear regression analysis is conducted on a dataset of privately financed healthcare projects in the UK to explore the main factors that might have significant relationships with the annual unitary charge payment. The results reveal that the economic and political environment, the hospital capacity, the construction duration, and the concession period are significant factors of the price paid by the granting authority. The study confirms that the unitary charge is not only affected by investment, operations and financial lifecycle costs, but also by risk factors and the level of risk allocated to the private sponsors. The proposed methodology might help both public and private parties in improving PFI project's compensation design, in order to achieve a higher value in privately financed infrastructures. The given model might also support the process of better determining the amount of annual payment based on select drivers and appropriately transferred risk factor

3D Surface Profile Construction and Flaw Detection in a Composite Structure

The nondestructive method of evaluating material properties and structural integrity is built upon ultrasonic scanning, raw data acquisition and processing, coming from an ultrasonic transducer. Commercial software LabVIEW designed by National Instruments Inc. is aimed at processing ultrasonic images. An ultrasonic C-scan image system was developed. This system is capable of constructing a 3D surface profile and detecting flaws inside the composite structure. The technique for nondestructive inspection and geometry estimation is validated experimentally on an aluminum plate with small holes and composite structure with a delamination defect.Неразрушающий метод оценки свойств материала и целостности структуры основан на ультразвуковом сканировании, сборе и обработке исходных данных, поступающих от ультразвукового датчика. Коммерческое программное обеспечение LabVLEW, разработанное National Instruments Inc., предназначено для обработки ультразвуковых изображений. Создана ультразвуковая система сканирования изображения С-scan. Система обладает функцией построения трехмерного профиля поверхности и выявления дефектов внутри композиционной структуры. Проверку достоверности методики неразрушающего контроля и оценку геометрии выполняли экспериментально на алюминиевой пластине с небольшими отверстиями и композиционной структуре с дефектом расслоения.Неруйнівний метод оцінки властивостей матеріалу і цілісності структури заснований на ультразвуковому скануванні, зборі та обробці вихідних даних, що надходять від ультразвукового датчика. Комерційне програмне забезпечення LabVLEW, розроблене National Instruments Inc., призначене для обробки ультразвукових зображень. Створена ультразвукова система сканування зображення С-scan. Система має функцію побудови тривимірного профілю поверхні і виявлення дефектів всередині композиційної структури. Перевірку достовірності методики неруйнівного контролю та оцінку геометрії виконували експериментально на алюмінієвій пластині з невеликими отворами і композиційній структурі з дефектом розшаруванн

Interfacial Fracture Toughness of Multilayer Composite Structures

The interfaces in multilayer composite structures are susceptible to delamination due to the combination of active tensile and shear loads under operating conditions. A four-layer center crack composite beam in four-point bending is simulated to determine the interfacial fracture energy of the multilayer structure. The crack is propagating along the interface between the second and third layers. Based on the Euler–Bernoulli theory, the strain energy of the four-layer composite beam is derived. Strain energies before and after the propagation of the interfacial crack are calculated, which results in determining strain energy release rates. Analytical results for those rates are validated with the numerical data obtained by the finite element method. The effect of layer thickness of the composite beam on the interfacial fracture toughness is investigated through a parametric study.В производственных условиях поверхности раздела в многослойных комбинированных структурах проявляют склонность к расслоению в результате комбинации действующих растягивающего усилия и усилия сдвига. Моделируется балка из четырехслойного комбинированного материала с центральной трещиной при четырехточечном изгибе с целью определения энергии разрушения на поверхности раздела многослойной структуры. Трещина развивается вдоль поверхности контакта между вторым и третьим слоями. Величину энергии деформации балки, полученную на основании теории Эйлера Бернулли, рассчитывали до и после распространения трещины по поверхности раздела, что позволило определять скорости выделения энергии деформации. Результаты анализа этих скоростей оценивали с помощью численных данных, полученных методом конечных элементов. Влияние толщины слоя комбинированного материала балки на вязкость разрушения по поверхности контакта изучали при параметрическом исследовании

Crystal structure of Li_2B_(12)H_(12): a possible intermediate species in the decomposition of LiBH_4

The crystal structure of solvent-free Li_2B_(12)H_(12) has been determined by powder X-ray diffraction and confirmed by a combination of neutron vibrational spectroscopy and first-principles calculations. This compound is a possible intermediate in the dehydrogenation of LiBH_4, and its structural characterization is crucial for understanding the decomposition and regeneration of LiBH_4. Our results reveal that the structure of Li_2B_(12)H_(12) differs from other known alkali-metal (K, Rb, and Cs) derivatives

Complaints of rape and the criminal justice system: Fresh evidence on the attrition problem in England and Wales

The UK has one of the lowest conviction rates for rape in Europe. This article presents unique evidence on the factors that influence the attrition of rape allegations in the English criminal justice system. The study is based on a large, representative sample of rape allegations reported to the London Metropolitan Police, the UK’s biggest police force. The dataset contains unprecedented detail on the incident, victim, suspect and police investigation. The results lend support to the influence of some rape myths and stereotypes on attrition. These findings suggest that further central factors include the ethnicity of the suspect as well as what police officers and prosecutors perceive as evidence against the truthfulness of the allegation: the police record noting a previous false allegation by the victim, inconsistencies in the victim’s account of the alleged rape, and evidence or police opinion casting doubt on the allegation

Identification of gene expression levels in primary melanoma associated with clinically meaningful characteristics

Factors influencing melanoma survival include sex, age, clinical stage, lymph node involvement, as well as Breslow thickness, presence of tumor-infiltrating lymphocytes based on histological analysis of primary melanoma, mitotic rate, and ulceration. Identification of genes whose expression in primary tumors is associated with these key tumor/patient characteristics can shed light on molecular mechanisms of melanoma survival. Here, we show results from a gene expression analysis of formalin-fixed paraffin-embedded primary melanomas with extensive clinical annotation. The Cancer Genome Atlas data on primary melanomas were used for validation of nominally significant associations. We identified five genes that were significantly associated with the presence of tumor-infiltrating lymphocytes in the joint analysis after adjustment for multiple testing: IL1R2, PPL, PLA2G3, RASAL1, and SGK2. We also identified two genes significantly associated with melanoma metastasis to the regional lymph nodes (PIK3CG and IL2RA), and two genes significantly associated with sex (KDM5C and KDM6A). We found that LEF1 was significantly associated with Breslow thickness and CCNA2 and UBE2T with mitosis. RAD50 was the gene most significantly associated with survival, with a higher level of expression associated with worse survival

Case management and Think First completion

“The final, definitive version of this article has been published in the Journal, Probation Journal, Vol 53 Issue 3, 2006, Copyright The Trade Union and Professional Association for Family Court and Probation Staff, by SAGE Publications Ltd at: http://prb.sagepub.com/ " DOI: 10.1177/0264550506066771This article considers the findings of a small-scale study of the practice of case managers supervising offenders required to attend the Think First Group. It explores the interface between one-to-one and group-based work within multi-modal programmes of supervision and seeks to identify those practices that support individuals in completing a group.Peer reviewe

The Risk of Unexploded Ordnance on Construction Sites in London

Greater London, among many large cities, was subject to bombing by the German military in both the World Wars and was the target of many air raids during the Second World War (WW2). This was particularly the case during the Blitz, September 1940 – May 1941, when over 28,000 high explosive bombs and parachute mines were dropped on London. Post war research conducted in 1949 estimated that approximately 12,750 t of bombs, including V1 and V2 rockets, were dropped on London. The night of 16th – 17th April 1941 was one of the worst bombing raids, when 446 t of bombs were dropped on London and over 58 t did not detonate. Unexploded bombs remain buried underground today, as they were unidentified at the time or abandoned owing to difficulties in recovering them. Uncharted bombs continue to pose a potentially significant hazard for developments around London. This paper considers the probability of discovering unexploded ordnance (UXO), particularly WW2 ordnance, during intrusive groundworks in London. The prevalence of unexploded ordnance has been assessed using data obtained from governmental organisations to estimate the likelihood of discovery in London

An open-label multi-center phase 1 safety study of BXQ-350 in children and young adults with relapsed solid tumors, including recurrent malignant brain tumors

BACKGROUND: BXQ-350 is a novel anti-neoplastic agent composed of saposin C (SapC) and phospholipid dioleoylphosphatidyl-serine sodium (DOPS) that selectively binds tumor cell phosphatidylserine (PS), inducing apoptosis. BXQ-350 has demonstrated preclinical antitumor effects in high-grade gliomas (HGG) and clinical activity in adult patients with recurrent HGG. METHODS: A phase 1 study was conducted in pediatric patients with relapsed/refractory solid tumors, including recurrent brain tumors. Primary objectives were to characterize safety and determine maximum tolerated dose (MTD) and preliminary antitumor activity. Sequential dose cohorts were assessed up to 3.2 mg/kg using an accelerated titration design. Each cycle was 28 days; dosing occurred on days 1-5, 8, 10, 12, 15, and 22 of cycle 1, and day 1 of subsequent cycles, until disease progression or toxicity. RESULTS: Nine patients, median age 10 years (range: 4-23), were enrolled. Seven patients (78%) had central nervous system (CNS) and two (22%) had non-CNS tumors. Eight patients completed cycle 1. No dose limiting toxicity (DLT) or BXQ-350-related serious adverse events (SAEs) were observed. Six patients experienced at least one adverse event (AE) considered possibly BXQ-350-related, most were grade ≤2. One patient with diffuse intrinsic pontine glioma experienced stable disease for 5 cycles. The study was terminated after part 1 to focus development on the frontline setting. CONCLUSION: No DLTs or BXQ-350-related SAEs were reported, and the maximal planned dose of 3.2 mg/kg IV was tolerable. Limited safety and efficacy data support continued BXQ-350 development in pediatric HGG; however, early discontinuations for progression suggest novel therapies be assessed at earlier disease stages