Exponential torsion growth for random 3-manifolds

We show that a random 3-manifold with positive first Betti number admits a tower of cyclic covers with exponential torsion growth

NPTI: New Periodic Emission Inspection to guarantee PN Emission Stability of all modern vehicles

Periodic Technical Inspection of emission quality PTI was abandoned by most EU member states in 2014 following the EU-Directive 2014/45 which recommended to delegate emission quality to OBD. After Dieselgate this naïve dream was over and VERT proposed during the German Dieselgate Hearing Sept.2016 to re-introduce PTI for all vehicles with emission control by DPF and SCR. With the introduction of particulate filters on diesel as well as GDI engines, the measurement of particulate emissions during PTI or road-side checks however, became a nontrivial task. Opacity and smoke meters do not have sufficient sensitivity to identify particulate filter failures or tampering on new, low emission internal combustion engines. Recent studies conducted in the Netherlands, Switzerland and Belgium have shown that about 10% of passenger cars equipped with DPF have high PN emissions that could indicate a damaged or removed DPF. To address this problem, the VERT Association launched a New Periodic Technical Inspection (N-PTI) initiative to develop a simple, robust and tamper-proof method for checking the functionality of DPFs using particle number (PN) instruments. The N-PTI initiative, launched in November 2016, is supported by the European Union as well as the governments of Germany, the Netherlands, Belgium, and Switzerland. The proposed test is conducted at idle using a PN instrument. It is assumed that the process will be suitable with minor, if any, modifications for petrol engines. The test protocol is also appropriate for road-side inspections, such as by the police. The first results are promising. Instruments in their prototype stage are already capable of recognizing vehicles that have been manipulated using partial bypass that resulted in PN emissions close to maximum allowed type approval levels (i.e., 6×1011 1/km) and present a satisfactory correlation with PEMS compliant instrumentation. Work on the testing procedure and pass/fail limit is still ongoing. This work is also under the evaluation of the CITA (International Motor Vehicle Inspection Committee) Roadworthiness Technical Working Group which focuses on tampering with exhaust emission control systems. The results show a good correlation between emission levels during the type approval cycle (NEDC/ WLTC) and low idle emissions even with first generation N-PTI instruments. These results suggest that the technical specifications of NPTI instruments should have acceptable uncertainty, with low cost. The Netherlands and Germany have already started programs that will lead to the adoption of mandatory N-PTI emission testing requirements. NMI, the Dutch metrology institute, has released a draft InternationalRecommendation with the specifications of the PTI particulate number counter. The N-PTI DPF test maybecome available in the Netherlands at RDW test stations as soon as 2019, while the nationwide targetdate for the introduction of N-PTI testing is 2021. In Germany, the Federal Council passed a law inSeptember 2017 (published in the German StVZO 2017) that re-introduces PTI first by smokemeasurement but PN measurements at idle are to be required from 2021

Progress of the Felsenkeller shallow-underground accelerator for nuclear astrophysics

Low-background experiments with stable ion beams are an important tool for putting the model of stellar hydrogen, helium, and carbon burning on a solid experimental foundation. The pioneering work in this regard has been done by the LUNA collaboration at Gran Sasso, using a 0.4 MV accelerator. In the present contribution, the status of the project for a higher-energy underground accelerator is reviewed. Two tunnels of the Felsenkeller underground site in Dresden, Germany, are currently being refurbished for the installation of a 5 MV high-current Pelletron accelerator. Construction work is on schedule and expected to complete in August 2017. The accelerator will provide intense, 50 uA, beams of 1H+, 4He+, and 12C+ ions, enabling research on astrophysically relevant nuclear reactions with unprecedented sensitivity.Comment: Submitted to the Proceedings of Nuclei in the Cosmos XIV, 19-24 June 2016, Niigata/Japa

Std fimbriae-fucose interaction increases Salmonella-induced intestinal inflammation and prolongs colonization

Author summary The intestinal epithelium is a crucial biological interface, interacting with both commensal and pathogenic microorganisms. It’s lined with heavily glycosylated proteins and glycolipids which can act as both attachment sites and energy sources for intestinal bacteria. Fut2, the enzyme governing epithelial α1,2-fucosylation, has been implicated in the interaction between microbes and intestinal epithelial cells. Salmonella is one of the most important bacterial gastrointestinal pathogens affecting millions of people worldwide. Salmonella possesses fimbrial and non-fimbrial adhesins which can be used to adhere to host cells. Here we show that Salmonella expresses Std fimbriae in the gastrointestinal tract in vivo and exploit Std fimbriae to bind fucosylated structures in the mucus and on the intestinal epithelium. Furthermore, we demonstrate that the Std fimbriae-fucose interaction is necessary for bacterial colonization of the intestine and for triggering intestinal inflammation. These data lend new insights into bacterial adhesion-epithelial interactions which are essential for bacterial pathogenesis and key factors in determining tissue tropism and host susceptibility to infectious disease

Discrimination of Vaccinated and infected Pigs by Salmonella-specific IGa antibodies

Isotype switching from IgM to IgG or IgA leads to generation of high affinity antibodies during the immune response. This phenomenon can be applied for differentiation of early and late infection stages. The purpose of this study was to evaluate the applicability of a newly developed Ig-isotype specific Salmonella antibody ELISA for discrimination between vaccinated and infected pigs. Using this novel ELISA we were able to detect different patterns of Salmonella-specific IgM, IgG and IgA antibodies following immunization with a S. Typhimurium live vaccine or after experimental infection with a nalidixic-acid resistant wild-type strain of S. Typhimurium. Interestingly, Salmonella-specific IgA antibodies represented an excellent tool for the recognition of fresh infection in vaccinated pigs. Under SPF conditions, we were able to discriminate between naive, vaccinated, experimentally infected nonvaccinated, and experimentally infected vaccinated animals. However, the highest specific IgA levels were detected in challenged vaccinated pigs. Preliminary results from field trials support the findings from experiments using SPF animals

Peer victimization and substance use: Understanding the indirect effect of depressive symptomatology across gender

OBJECTIVE: Peer victimization in school is common, with emerging literature suggesting that it may also increase risk for substance abuse. Yet, little is known about the underlying mechanisms within this risk pathway. The objective of this study is to use a prospective 3-wave design to examine the mediating role of depressive symptomatology on the relationship between peer victimization and substance use, as well as examine if the pathway varies based on gender. METHOD: 801 youth between 6th and 12th grade completed surveys across three years, which included measures on school peer victimization, depression symptomatology and substance use. Models tested the mediational pathway between victimization, depressive symptoms, and substance use. Models were stratified by gender. RESULTS: Controlling for grade and the effect of each variable across waves, a significant indirect effect of peer victimization on substance use through depressive symptoms was found for females, with a non-significant indirect effect for males. CONCLUSION: Results suggest that female youth who are victimized by peers engage in substance use behaviors, at least in part, due to increases in depressive symptoms. Given its effect on depression, female victims may therefore benefit from coping skills training that targets emotion regulation and distress tolerance skills in order to combat increased risk for substance use behaviors as a coping response to their victimization. Further research is warranted to better understand the risk pathway for male youth who also experience peer victimization

Excitonic condensate and quasiparticle transport in electron-hole bilayer systems

Bilayer electron-hole systems undergo excitonic condensation when the distance d between the layers is smaller than the typical distance between particles within a layer. All excitons in this condensate have a fixed dipole moment which points perpendicular to the layers, and therefore this condensate of dipoles couples to external electromagnetic fields. We study the transport properties of this dipolar condensate system based on a phenomenological model which takes into account contributions from the condensate and quasiparticles. We discuss, in particular, the drag and counterflow transport, in-plane Josephson effect, and noise in the in-plane currents in the condensate state which provides a direct measure of the superfluid collective-mode velocity.Comment: 7 pages, 3 figure

Peer Victimization, Mood Symptoms, and Alcohol Use: Examining Effects Among Diverse High School Youth

Peer victimization is associated with alcohol use among adolescents. However, few studies have examined the mediating role of depression and anxiety, or differences by race. The current study examined the prospective relationship of peer victimization, depressive and anxiety symptoms, and alcohol use across two timeframes: 9th to 11th grade and 10th to 12th grade among African American and White youth. 2,202 high school youth (57.6% female) who identified as either African American (n=342, 15.2%) or White (n=1860, 82.6%) provided data on study variables. Path analysis among the overall sample indicated that anxiety symptoms was a significant mediator for both timeframes, with depressive symptoms mediating the pathway during the 10th to 12th grade timeframe. The findings were most consistent among White youth, with no significant indirect effects observed for African American youth. Thus, addressing depressive and anxiety symptoms may be effective targets to decrease alcohol use risk as a result of peer victimization among White youth. However, further research is needed to better understand risk models for peer victimization exposure on substance use outcomes among racial/ethnic minority youth