Co-expression of Gbeta 5 Enhances the Function of Two Ggamma Subunit-like Domain-containing Regulators of G Protein Signaling Proteins

Regulators of G protein signaling (RGS) stimulate the GTPase activity of G protein Galpha subunits and probably play additional roles. Some RGS proteins contain a Ggamma subunit-like (GGL) domain, which mediates a specific interaction with Gbeta 5. The role of such interactions in RGS function is unclear. RGS proteins can accelerate the kinetics of coupling of G protein-coupled receptors to G-protein-gated inwardly rectifying K+ (GIRK) channels. Therefore, we coupled m2-muscarinic acetylcholine receptors to GIRK channels in Xenopus oocytes to evaluate the effect of Gbeta 5 on RGS function. Co-expression of either RGS7 or RGS9 modestly accelerated GIRK channel kinetics. When Gbeta 5 was co-expressed with either RGS7 or RGS9, the acceleration of GIRK channel kinetics was strongly increased over that produced by RGS7 or RGS9 alone. RGS function was not enhanced by co-expression of Gbeta 1, and co-expression of Gbeta 5 alone had no effect on GIRK channel kinetics. Gbeta 5 did not modulate the function either of RGS4, an RGS protein that lacks a GGL domain, or of a functional RGS7 construct in which the GGL domain was omitted. Enhancement of RGS7 function by Gbeta 5 was not a consequence of an increase in the amount of plasma membrane or cytosolic RGS7 protein

Very high-current-density Nb/AlN/Nb tunnel junctions for low-noise submillimeter mixers

We have fabricated and tested submillimeter-wave superconductor–insulator–superconductor (SIS) mixers using very high-current-density Nb/AlN/Nb tunnel junctions (Jc[approximate]30 kA cm–2). The junctions have low-resistance-area products (RNA[approximate]5.6 Omega µm2), good subgap-to-normal resistance ratios Rsg/RN[approximate]10, and good run-to-run reproducibility. From Fourier transform spectrometer measurements, we infer that omegaRNC = 1 at 270 GHz. This is a factor of 2.5 improvement over what is generally available with Nb/AlOx/Nb junctions suitable for low-noise mixers. The AlN-barrier junctions are indeed capable of low-noise operation: we measure an uncorrected double-sideband receiver noise temperature of TRX = 110 K at 533 GHz for an unoptimized device. In addition to providing wider bandwidth operation at lower frequencies, the AlN-barrier junctions will considerably improve the performance of THz SIS mixers by reducing rf loss in the tuning circuits

Proper Actions of Automorphism Groups of Free Products of Finite Groups

If G is a free product of finite groups, let ΣAut1(G) denote all (necessarily symmetric) automorphisms of G that do not permute factors in the free product. We show that a McCullough–Miller and Gutiérrez–Krstić derived (also see Bogley–Krstić) space of pointed trees is an EΣAut1(G)-space for these groups

Passive Tracking System and Method

System and methods are disclosed for passively determining the location of a moveable transmitter utilizing a pair of phase shifts at a receiver for extracting a direction vector from a receiver to the transmitter. In a preferred embodiment, a phase difference between the transmitter and receiver is extracted utilizing a noncoherent demodulator in the receiver. The receiver includes antenna array with three antenna elements, which preferably are patch antenna elements placed apart by one-half wavelength. Three receiver channels are preferably utilized for simultaneously processing the received signal from each of the three antenna elements. Multipath transmission paths for each of the three receiver channels are indexed so that comparisons of the same multipath component are made for each of the three receiver channels. The phase difference for each received signal is determined by comparing only the magnitudes of received and stored modulation signals to determine a winning modulation symbol

Path deviations outperform approximate stability in heterogeneous congestion games

We consider non-atomic network congestion games with heterogeneous players where the latencies of the paths are subject to some bounded deviations. This model encompasses several well-studied extensions of the classical Wardrop model which incorporate, for example, risk-aversion, altruism or travel time delays. Our main goal is to analyze the worst-case deterioration in social cost of a perturbed Nash flow (i.e., for the perturbed latencies) with respect to an original Nash flow. We show that for homogeneous players perturbed Nash flows coincide with approximate Nash flows and derive tight bounds on their inefficiency. In contrast, we show that for heterogeneous populations this equivalence does not hold. We derive tight bounds on the inefficiency of both perturbed and approximate Nash flows for arbitrary player sensitivity distributions. Intuitively, our results suggest that the negative impact of path deviations (e.g., caused by risk-averse behavior or latency perturbations) is less severe than approximate stability (e.g., caused by limited responsiveness or bounded rationality). We also obtain a tight bound on the inefficiency of perturbed Nash flows for matroid congestion games and homogeneous populations if the path deviations can be decomposed into edge deviations. In particular, this provides a tight bound on the Price of Risk-Aversion for matroid congestion games

Structures in the Gauge/Gravity Duality Cascade

We study corrections to the anomalous mass dimension and their effects in the Seiberg duality cascade in the Klebanov-Strassler throat, where $\mathcal{N}=1$ supersymmetric $SU(N+M)\times SU(N)$ gauge theory with bifundamental chiral superfields and a quartic tree level superpotential in four dimensions is dual to type IIB string theory on $AdS_5 \times T^{1,1}$ background. Analyzing the renormalization group flow of the couplings on the gauge theory side, we propose specific corrections to the anomalous mass dimension. Applying gauge/gravity duality, we then show that the corrections reveal structures on the supergravity side with steps appearing in the running of the fluxes and the metric. The "charges" at the steps provide a gravitational source for Seiberg duality transformations. The finiteness of these corrections suggests that the theory flows to a baryonic branch rather than to a confining branch. The cosmological implication of the duality cascade and the gauge/gravity duality on the brane inflationary scenario and the cosmic microwave background radiation is pointed out.Comment: v3: 40 pages, minor changes and typos fixe

Lithium Batteries and the Solid Electrolyte Interphase (SEI)—Progress and Outlook

Interfacial dynamics within chemical systems such as electron and ion transport processes have relevance in the rational optimization of electrochemical energy storage materials and devices. Evolving the understanding of fundamental electrochemistry at interfaces would also help in the understanding of relevant phenomena in biological, microbial, pharmaceutical, electronic, and photonic systems. In lithium-ion batteries, the electrochemical instability of the electrolyte and its ensuing reactive decomposition proceeds at the anode surface within the Helmholtz double layer resulting in a buildup of the reductive products, forming the solid electrolyte interphase (SEI). This review summarizes relevant aspects of the SEI including formation, composition, dynamic structure, and reaction mechanisms, focusing primarily on the graphite anode with insights into the lithium metal anode. Furthermore, the influence of the electrolyte and electrode materials on SEI structure and properties is discussed. An update is also presented on state-of-the-art approaches to quantitatively characterize the structure and changing properties of the SEI. Lastly, a framework evaluating the standing problems and future research directions including feasible computational, machine learning, and experimental approaches are outlined