Nonodontogenic cysts of the oral and maxillofacial region - demographic profile in a Brazilian population over a 40-year period

The aim of the study was to determine the distribution of histologically diagnosed nonodontogenic cysts (nOCs) over a 40-year period in a Brazilian population. Biopsy records from patients with nOC from the files of the Oral Pathology Service during the period of 1970–2009 were evaluated. Among 10,311 oral biopsies, 58 met the criteria of nOCs. The most frequent nOCs were nasopalatine duct cysts (32.8%), followed by epidermoid cysts (20.7%) and oral lymphoepithelial cysts (17.2%). Nasopalatine duct cysts showed predominance among females (68.4%). Epidermoid cysts were most commonly found in the floor of the mouth (36.4%), tongue (27.3%), and buccal mucosa (27.3%). Oral lymphoepithelial cysts exhibited female prevalence (80.0%) and were commonly located in the tongue (44.4%). The frequency of nOCs found in the population studied here is slightly different from those reported in other case series. Nasopalatine duct cysts, epidermoid cysts, and oral lymphoepithelial cysts were the most common nOCs found, accounting for 70.7% of all nOCs

Epidemiological survey of mucus extravasation phenomenon at an oral pathology referral center during a 43 year period

ABSTRACT INTRODUCTION: Mucoceles are common benign pseudocystic lesions of the oral cavity; their main etiological factors are trauma and ductal obstruction. Two histological patterns are found: mucus retention phenomenon (MRP) and mucus extravasation phenomenon (MEP). Mucus extravasation phenomenon is the more common histological subtype and it mainly affects the lower lip. The knowledge of its main clinical features and management is important to assist health professionals in clinical practice. OBJECTIVE: This study aimed to determine the relative frequency and distribution of oral mucoceles in an oral pathology reference center. METHODS: Cross-sectional historical study that analyzed all cases pathologically diagnosed as mucus extravasation phenomenon by the department of anatomic pathology of an oral pathology referral center from June of 1970 to May of 2014, considering the clinical characteristics of the lesion and those relating to the patient. SPSS v. 20.0 software for Windows was used for descriptive analysis. RESULTS: During 43 years, 719 cases of mucus extravasation phenomenon (54.7% men and 45.3% women) were registered, with the lower lip as the most commonly affected site (n = 484; 67.3%). The average age of patients was 20.8 years (SD ± 14.4) with a peak occurrence in the second decade of life. Most professionals had oral mucocele/ranula (n = 606; 84.3%) as the initial clinical impression. CONCLUSION: Mucus extravasation phenomenon is a lesion that primarily affects young patients, affecting mainly the lower lip, and is commonly found in oral diagnostic services

Dermoid and epidermoid cysts of the mouth: Clinicopathological and cytokeratin profile

Clarissa Araújo Gurgel. Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2019-07-16T18:00:50Z No. of bitstreams: 1 Schitini Junior, O. Dermoid epidermoid....2019.pdf: 1443984 bytes, checksum: d456f68b174c2860d92b0ad1137893aa (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2019-07-16T18:14:53Z (GMT) No. of bitstreams: 1 Schitini Junior, O. Dermoid epidermoid....2019.pdf: 1443984 bytes, checksum: d456f68b174c2860d92b0ad1137893aa (MD5)Made available in DSpace on 2019-07-16T18:14:53Z (GMT). No. of bitstreams: 1 Schitini Junior, O. Dermoid epidermoid....2019.pdf: 1443984 bytes, checksum: d456f68b174c2860d92b0ad1137893aa (MD5) Previous issue date: 2019CNPQ (Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil) and CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil).Universidade Federal da Bahia. Dental School. Department of Propaedeutic and Integrated Clinic. Salvador, BA, Brazil.Universidade Federal da Bahia. Dental School. Department of Propaedeutic and Integrated Clinic. Salvador, BA, Brazil.Universidade Estadual de Feira de Santana. Dental School. Department of Propaedeutic and Integrated Clinic. Feira de Santana, BA, Brazil.Universidade Federal da Bahia. Dental School. Department of Propaedeutic and Integrated Clinic. Salvador, BA, Brazil.Universidade Federal da Bahia. Dental School. Department of Propaedeutic and Integrated Clinic. Salvador, BA, Brazil.Universidade Federal do Rio Grande do Norte. Dental School. Department of Oral Pathology. Natal, RN,Universidade Federal da Bahia. Dental School. Department of Propaedeutic and Integrated Clinic. Salvador, BA, Brazil.Universidade Federal da Bahia. Dental School. Department of Propaedeutic and Integrated Clinic. Salvador, BA, Brazil.Universidade Federal da Bahia. Dental School. Department of Propaedeutic and Integrated Clinic. Salvador, BA, Brazil.Universidade Federal da Bahia. Dental School. Department of Propaedeutic and Integrated Clinic. Salvador, BA, Brazil.Introduction: The mechanisms of cell differentiation and pathogenesis in oral epidermoid cysts and dermoid cyst is poorly know. Objective: To report clinicopathological features and investigate cytokeratin profile of oral epidermoid cysts and dermoid cyst. Material and Methods: Eight cases of epidermoid cysts, 4 of dermoid cyst, and 2 Fordyce granules were included. For analysis of the immunohistochemical expression of cytokeratins (6, 7, 8, 10, 13, 14, 18 and 19), brown staining in the sections examined were defined as positive considering three layers: superficial, intermediate and basal. Results: In dermoid cyst, cytokeratins 7, 8, 9 and 19 were expressed in one case. Cytokeratin 6 was detected in six cases of epidermoid cysts. Cytokeratins 10, 13 and 14 were expressed in all cysts. Cytokeratin 18 was absent in all cysts. Cytokeratins 10 and 14 was observed in Fordyce granules. Cytokeratin 10 was more expressed in peripheral cells and immature sebaceous glands. As these glands became more differentiated, cytokeratin 10 was not detected, while cytokeratin 14 was expressed in mature sebocytes. Cytokeratins 10, 13 and 14 were expressed in the lining mucosa adjacent to Fordyce granules, similar to normal oral mucosal lining. Conclusion: cytokeratin profile is altered in dermoid cyst and epidermoid cysts compared to lining oral mucosa