Splanchnic Removal of Atrial Natriuretic Factor (ANF) in Man

In order to assess the effect of food ingestion on splanchnic disposal of human alpha-atrial natriuretic peptide (ANF), hepatic-intestinal removal of ANF was determined before and after a test meal. Hepatic venous and arterial plasma samples were obtained from six subjects, most of whom had only disorders of minor degree. Hepatic blood flow (HBF) increased significantly after meal ingestion (1.10 ± 0.17 [SEM] to 1.51 ± 0.26 L/min, P < .01). Baseline arterial ANF (10.9 ± 3.1 pmol/L) did not change significantly. In contrast, hepatic venous ANF increased after meal intake (5.7 ± 2.0 to 8.4 ± 1.9 pmol/L, P < .05), and accordingly the splanchnic fractional extraction decreased (0.53 ± 0.09 to 0.35 ± 0.08), although this was not statistically significant. Splanchnic clearance of ANF increased from 347 ± 90 mL/min to a maximal value of 615 ± 158 mL/min (P < .05). Splanchnic removal of ANF was 3.0 ± 0.5 pmol/min before and increased to a maximum value (7.1 ± 2.2 pmol/min, P < .05) 35 minutes after ingestion of the meal. Our results showed enhanced splanchnic removal of ANF after food intake. This is due to increased hepatic-intestinal clearance of the peptide consequent on increased splanchnic blood flow, rather than altered fractional extraction of ANF

Radio jet refraction in galactic atmospheres with static pressure gradients

A theory of double radio sources which have a 'Z' or 'S' morphology is proposed, based on the refraction of radio jets in the extended atmosphere of an elliptical galaxy. The model describes a collimated jet of supersonic material bending self-consistently under the influence of external static pressure gradients. Gravity and magnetic fields are neglected in the simplest case except insofar as they determine the static pressure distribution. The calculation is a straightforward extension of a method used to calculate a ram-pressure model for twin radio trails ('C' morphology). It may also be described as a continuous-jet version of a buoyancy model proposed in 1973. The model has the added virtue of invoking a galactic atmosphere similar to those already indicated by X-ray measurements of some other radio galaxies and by models for the collimation of other radio jets

Synchrotron brightness distribution of turbulent radio jets

Radio jets are considered as turbulent mixing regions and it is proposed that the essential small scale viscous dissipation in these jets is by emission of MHD waves and by their subsequent strong damping due, at least partly, to gyro-resonant acceleration of supra-thermal particles. A formula relating the synchrotron surface brightness of a radio jet to the turbulent power input is deduced from physical postulates, and is tested against the data for NGC315 and 3C31 (NGC383). The predicted brightness depends essentially on the collimation behavior of the jet, and, to a lesser extent, on the CH picture of a 'high' nozzle with accelerating flow. The conditions for forming a large scale jet at a high nozzle from a much smaller scale jet are discussed. The effect of entrainment on the prediction is discussed with the use of similarity solutions. Although entrainment is inevitably associated with the turbulent jet, it may or may not be a dominant factor depending on the ambient density profile

Harmonised Principles for Public Participation in Quality Assurance of Integrated Water Resources Modelling

The main purpose of public participation in integrated water resources modelling is to improve decision-making by ensuring that decisions are soundly based on shared knowledge, experience and scientific evidence. The present paper describes stakeholder involvement in the modelling process. The point of departure is the guidelines for quality assurance for `scientific` water resources modelling developed under the EU research project HarmoniQuA, which has developed a computer based Modelling Support Tool (MoST) to provide a user-friendly guidance and a quality assurance framework that aim for enhancing the credibility of river basin modelling. MoST prescribes interaction, which is a form of participation above consultation but below engagement of stakeholders and the public in the early phases of the modelling cycle and under review tasks throughout the process. MoST is a flexible tool which supports different types of users and facilitates interaction between modeller, manager and stakeholders. The perspective of using MoST for engagement of stakeholders e.g. higher level participation throughout the modelling process as part of integrated water resource management is evaluate

Muscle protein and glycogen responses to recovery from hypogravity and unloading by tail-cast suspension

Previous studies in this laboratory using the tail-bast hindlimb suspension model have shown that there are specific changes in protein and carbohydrate metabolism in the soleus muscle due to unloading. For example, 6 days of unloading caused a 27% decrease in mass and a 60% increase in glycogen content in the soleus muscle, while the extensor digitorum longus muscle was unaffected. Also, fresh tissue tyrosine and its in vitro release from the muscle are increased in the unloaded soleus, indicating that this condition causes a more negative protein balance. With these results in mind, studies to investigate the effect of hypogravity on protein and carbohydrate metabolism in a number of rat hindlimb muscles were carried out