Treatment of relapsing chronic infections of the respiratory tract: a comparative study of the effectiveness of non specific immunotherapy with the immunoadjuvant p40 and of vaccinotherapy

The treatment of relapsing chronic infections (RCI) encounters many difficulties. In the present study, the use of the immuno adjuvant P40 either alone or in association with vaccinotherapy for the treatment of RCI turned out to be very effective, whereas vaccinotherapy alone was not. It is hypothesized that cell-mediated immunity may play a major role in controlling RCI, since the clinical improvement of the patients kept up with the positivation of previously negative skin tests carried out with either the specific infecting agent or with recall-anti gens

Tratamento de infecções crônicas recidivantes do aparelho respiratório: estudo comparativo da eficácia da imunoterapia inespecífica através do imunoadjuvante P40 e da vacinoterapia.

O tratamento de infecções crônicas recidivantes (I.C.R.) encontra muitas dificuldades. No presente estudo, o uso do imunoadjuvante P40, quer isolado, quer associado a vacinoterapia no tratamento de I.C.R., demonstrou ser muito eficaz, ao passo que a vacinoterapia isoladamente não o foi. Foi aventada a hipótese de que a imunidade mediada por células pode desempenhar papel importante no contrôle das I.C.R., uma vez que a melhora clínica dos pacientes foi acompanhada de positivação de testes cutâneos anteriormente negativos, testes estes realizados quer com o agente infeccioso específico, quer com antígeno inespecífico de refôrço.The treatment of relapsing chronic infections (RCI) encounters many difficulties. In the present study, the use of the immuno adjuvant P40 either alone or in association with vaccinotherapy for the treatment of RCI turned out to be very effective, whereas vaccinotherapy alone was not. It is hypothesized that cell-mediated immunity may play a major role in controlling RCI, since the clinical improvement of the patients kept up with the positivation of previously negative skin tests carried out with either the specific infecting agent or with recall-anti gens

Treatment of relapsing chronic infections of the respiratory tract: a comparative study of the effectiveness of non specific immunotherapy with the immunoadjuvant p40 and of vaccinotherapy Tratamento de infecções crônicas recidivantes do aparelho respiratório: estudo comparativo da eficácia da imunoterapia inespecífica através do imunoadjuvante P40 e da vacinoterapia.

The treatment of relapsing chronic infections (RCI) encounters many difficulties. In the present study, the use of the immuno adjuvant P40 either alone or in association with vaccinotherapy for the treatment of RCI turned out to be very effective, whereas vaccinotherapy alone was not. It is hypothesized that cell-mediated immunity may play a major role in controlling RCI, since the clinical improvement of the patients kept up with the positivation of previously negative skin tests carried out with either the specific infecting agent or with recall-anti gens.O tratamento de infecções crônicas recidivantes (I.C.R.) encontra muitas dificuldades. No presente estudo, o uso do imunoadjuvante P40, quer isolado, quer associado a vacinoterapia no tratamento de I.C.R., demonstrou ser muito eficaz, ao passo que a vacinoterapia isoladamente não o foi. Foi aventada a hipótese de que a imunidade mediada por células pode desempenhar papel importante no contrôle das I.C.R., uma vez que a melhora clínica dos pacientes foi acompanhada de positivação de testes cutâneos anteriormente negativos, testes estes realizados quer com o agente infeccioso específico, quer com antígeno inespecífico de refôrço

Vertical variability of Near-Surface Salinity in the Tropics : Consequences for SMOS Calibration and Validation

International audienceThe ESA/SMOS (European Space Agency/Soil Moisture and Ocean Salinity) satellite mission aims to detect Sea Surface Salinity (SSS) using L-band radiometry. At that frequency, the skin depth is 1 centimeter. However, the calibration and validation of SMOS measurements will be done with in situ measurements, mainly taken at 5 m depth. In order to anticipate and understand vertical salinity differences in the first 10 m of the ocean surface layer, in situ vertical profiles are analyzed. Measurements come from autonomous drifter and Tropical Atmosphere Ocean (TAO) moorings for observations on local scale and from thermosalinographs (TSG), floats, eXpendable Conductivity-Temperature-Depth (XCTD) and CTD on the entire tropical band (from 30°S to 30°N). For the first time, vertical salinity differences, classified according to their vertical position, are collocated with precipitation computed by satellite. A rain parameter, 3D max rain rate, is defined to take into account the history of rain events. Vertical salinity differences higher than 0.1 pss-78 are observed in the 3 oceans, mainly between 0° and 15°N, coinciding with the average position of the InterTropical Convergence Zone. The highest differences are mainly located near river mouth. Some differences exceed 0.5 pss-78 locally and persist for more than 10 days, unlike the spatial average of salinity differences between 10 m and 1 m, which stay close to 0. A statistical approach is developed to be used for predicting large vertical salinity differences

Use of quantitative digital autoradiography technique to investigate the chlorine-36-labelled radiotracer transport in concrete

International audienceThis work presents the capability of digital autoradiography, a non-destructive technique, to improve diffusion parameters determination by the mean of high resolution radionuclide mapping. Results show a good agreement between Cl-36 diffusion profiles acquired by digital autoradiography compared to the classic protocol based onto multi-step-abrasive-surface-peeling procedure. The digital autoradiography technique has been successfully used to localize and quantify Cl-36-labelled radiotracer on the surface of a concrete sample and into the contaminated depth. This study shows how optimized in-diffusion investigations can be performed in only 100 days to assess the diffusion parameters of Cl-36 in a low diffusive concrete sample, while a classical diffusion experiment would take several years to reach diffusion steady state for tritiated water, consider as the reference tracer, and consequently, to allow the estimation of the diffusion parameters for Cl-36

Cement-Based Matrix for tritium trapping research project: MACH3 (PIA2/ANDRA)

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