The Grizzly, November 18, 2021

Ursinus College Democrats Making a Comeback • Bears Frightened Bullets • Bears Bring in Bucks for #Giving2UCDay • The Re Mark able Feinberg • Exchanging Sticks for Cameras • Opinions: A Spooky Homecoming; Life After Ursinus: What Will I Do? • SAAC\u27s Spicy Spirit Week • Women\u27s Soccer Final Kickhttps://digitalcommons.ursinus.edu/grizzlynews/1974/thumbnail.jp

The Grizzly, April 8, 2021

Anger About Admitted Students Day • Eligible Faculty, Staff, and Students Granted Opportunity to Participate in Vaccine Clinic • A Baden Presentation by Kneia DaCosta, Psychology Department • Ally Hendrikson \u2721: A Graduating Senior Interview • Kappa Alpha Psi Fraternity Incorporated • Opinion: The Enemy That Became my Friend; Nomadland Film Review • Spring Sports Week Two Recap • What is Next for Women\u27s LAX?https://digitalcommons.ursinus.edu/grizzlynews/1955/thumbnail.jp

Noninvasive Physical Plasma as Innovative and Tissue-Preserving Therapy for Women Positive for Cervical Intraepithelial Neoplasia

(1) Background: Cervical intraepithelial neoplasia (CIN) of long-term persistence or associated with individual treatment indications often requires highly invasive treatments. These are associated with risks of bleeding, infertility, and pregnancy complications. For low- and middle-income countries (LMICs), standard treatment procedures are difficult to implement and manage. We characterized the application of the highly energized gas “noninvasive physical plasma” (NIPP) for tissue devitalization and the treatment of CIN. (2) Methods: We report the establishment of a promising tissue devitalization procedure by NIPP application. The procedure was characterized at the in vitro, ex vivo and in vivo levels. We performed the first prospective, single-armed phase-IIb trial in 20 CIN1/2 patients (NCT03218436). (3) Results: NIPP-treated cervical cancer cells used as dysplastic in vitro model exhibited significant cell growth retardation due to DNA damage, cell cycle arrest and apoptosis. Ex vivo and in vivo tissue assessments showed a highly noninvasive and tissue-preserving treatment procedure which induces transmucosal tissue devitalization. Twenty participants were treated with NIPP and attended a 24-week follow-up. Treatment success was achieved in 19 (95%) participants without postinterventional complications other than mild to moderate discomfort during application. (4) Conclusions: The results from this study preliminarily suggest that NIPP could be used for an effective and tissue-preserving treatment for CIN without the disadvantages of standard treatments. However, randomized controlled trials must confirm the efficacy and noninferiority of NIPP compared to standard treatments