768 research outputs found
Smectic phases in ionic liquid crystals
Ionic liquid crystals (ILCs) are anisotropic mesogenic molecules which carry
charges and therefore combine properties of liquid crystals, e.g., the
formation of mesophases, and of ionic liquids, such as low melting temperatures
and tiny triple-point pressures. Previous density functional calculations have
revealed that the phase behavior of ILCs is strongly affected by their
molecular properties, i.e., their aspect ratio, the loci of the charges, and
their interaction strengths. Here, we report new findings concerning the phase
behavior of ILCs as obtained by density functional theory and Monte Carlo
simulations. The most important result is the occurrence of a novel, wide
smectic-A phase , at low temperature, the layer spacing of which is
larger than that of the ordinary high-temperature smectic-A phase .
Unlike the ordinary smectic phase, the structure of the phase
consists of alternating layers of particles oriented parallel to the layer
normal and oriented perpendicular to it
Interface structures in ionic liquid crystals
Ionic liquid crystals (ILCs) are anisotropic mesogenic molecules which
additionally carry charges. This combination gives rise to a complex interplay
of the underlying (anisotropic) contributions to the pair interactions. It
promises interesting and distinctive structural and orientational properties to
arise in systems of ILCs, combining properties of liquid crystals and ionic
liquids. While previous theoretical studies have focused on the phase behavior
of ILCs and the structure of the respective bulk phases, in the present study
we provide new results, obtained within density functional theory, concerning
(planar) free interfaces between an isotropic liquid and two types of
smectic-A phases ( or ). We discuss the structural and
orientational properties of these interfaces in terms of the packing fraction
profile and the orientational order parameter profile
concerning the tilt angle between the (bulk) smectic
layer normal and the interface normal. The asymptotic decay of
and of towards their values in the isotropic bulk is discussed,
too
Von der Lehr- zur Lernorientierung – auf dem Weg zu einer rechtswissenschaftlichen Fachdidaktik
Die Verbesserung der Hochschullehre gerät an den juristischen Fakultäten in Deutschland zunehmend in den Blick. Der Beitrag widmet sich Grundsatzfragen der Wissensvermittlung und Wissensaneignung im rechtswissenschaftlichen Studium
3D-Printed Scanning-Probe Microscopes with Integrated Optical Actuation and Read-Out
Scanning‐probe microscopy (SPM) is the method of choice for high‐resolution imaging of surfaces in science and industry. However, SPM systems are still considered as rather complex and costly scientific instruments, realized by delicate combinations of microscopic cantilevers, nanoscopic tips, and macroscopic read‐out units that require high‐precision alignment prior to use. This study introduces a concept of ultra‐compact SPM engines that combine cantilevers, tips, and a wide variety of actuator and read‐out elements into one single monolithic structure. The devices are fabricated by multiphoton laser lithography as it is a particularly flexible and accurate additive nanofabrication technique. The resulting SPM engines are operated by optical actuation and read‐out without manual alignment of individual components. The viability of the concept is demonstrated in a series of experiments that range from atomic‐force microscopy engines offering atomic step height resolution, their operation in fluids, and to 3D printed scanning near‐field optical microscopy. The presented approach is amenable to wafer‐scale mass fabrication of SPM arrays and capable to unlock a wide range of novel applications that are inaccessible by current approaches to build SPMs
Extrinsic intestinal denervation modulates tumor development in the small intestine of ApcMin/+ mice
Background Innervation interacts with enteric immune responses. Chronic
intestinal inflammation is associated with increased risk of colorectal
cancer. We aimed to study potential extrinsic neuronal modulation of
intestinal tumor development in a mouse model. Methods Experiments were
performed with male ApcMin/+ or wild type mice (4 weeks old, body weight
approximately 20 g). Subgroups with subdiaphragmatic vagotomy (apcV/wtV),
sympathetic denervation of the small intestine (apcS/wtS) or sham operated
controls (apcC/wtC) were investigated (n = 6-14 per group). Three months after
surgical manipulation, 10 cm of terminal ileum were excised, fixed for 48 h in
4% paraformaldehyde and all tumors were counted and their area determined in
mm2 (mean ± standard error of the mean (SEM)). Whole mounts of the muscularis
of terminal ileum and duodenum (internal positive control) were also stained
for tyrosine hydroxylase to confirm successful sympathetic denervation.
Results Tumor count in ApcMin/+ mice was 62 ± 8 (apcC), 46 ± 11 (apcV) and 54
± 8 (apcS) which was increased compared to wildtype controls with 4 ± 0.5
(wtC), 5 ± 0.5 (wtV) and 5 ± 0.6 (wtS; all p < 0.05). For ApcMin/+ groups,
vagotomized animals showed a trend towards decreased tumor counts compared to
sham operated ApcMin/+ controls while sympathetic denervation was similar to
sham ApcMin/+. Area covered by tumors in ApcMin/+ mice was 55 ± 10 (apcC), 31
± 8 (apcV) and 42 ± 8 (apcS) mm2, which was generally increased compared to
wildtype controls with 7 ± 0.6 (wtC), 7 ± 0.4 (wtV) and 7 ± 0.6 (wtS) mm2 (all
p < 0.05). In ApcMin/+ groups, tumor area was decreased in vagotomized animals
compared to sham operated controls (p < 0.05) while sympathetically denervated
mice showed a minor trend to decreased tumor area compared to controls.
Conclusions Extrinsic innervation of the small bowel is likely to modulate
tumor development in ApcMin/+ mice. Interrupted vagal innervation, but not
sympathetic denervation, seems to inhibit tumor growth
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