314 research outputs found
Dose, exposure time, and resolution in Serial X-ray Crystallography
The resolution of X-ray diffraction microscopy is limited by the maximum dose
that can be delivered prior to sample damage. In the proposed Serial
Crystallography method, the damage problem is addressed by distributing the
total dose over many identical hydrated macromolecules running continuously in
a single-file train across a continuous X-ray beam, and resolution is then
limited only by the available molecular and X-ray fluxes and molecular
alignment. Orientation of the diffracting molecules is achieved by laser
alignment. We evaluate the incident X-ray fluence (energy/area) required to
obtain a given resolution from (1) an analytical model, giving the count rate
at the maximum scattering angle for a model protein, (2) explicit simulation of
diffraction patterns for a GroEL-GroES protein complex, and (3) the frequency
cut off of the transfer function following iterative solution of the phase
problem, and reconstruction of an electron density map in the projection
approximation. These calculations include counting shot noise and multiple
starts of the phasing algorithm. The results indicate counting time and the
number of proteins needed within the beam at any instant for a given resolution
and X-ray flux. We confirm an inverse fourth power dependence of exposure time
on resolution, with important implications for all coherent X-ray imaging. We
find that multiple single-file protein beams will be needed for sub-nanometer
resolution on current third generation synchrotrons, but not on fourth
generation designs, where reconstruction of secondary protein structure at a
resolution of 0.7 nm should be possible with short exposures.Comment: 19 pages, 7 figures, 1 tabl
Symbolic Manipulators Affect Mathematical Mindsets
Symbolic calculators like Mathematica are becoming more commonplace among
upper level physics students. The presence of such a powerful calculator can
couple strongly to the type of mathematical reasoning students employ. It does
not merely offer a convenient way to perform the computations students would
have otherwise wanted to do by hand. This paper presents examples from the work
of upper level physics majors where Mathematica plays an active role in
focusing and sustaining their thought around calculation. These students still
engage in powerful mathematical reasoning while they calculate but struggle
because of the narrowed breadth of their thinking. Their reasoning is drawn
into local attractors where they look to calculation schemes to resolve
questions instead of, for example, mapping the mathematics to the physical
system at hand. We model the influence of Mathematica as an integral part of
the constant feedback that occurs in how students frame, and hence focus, their
work
Biomechanical Comparison of Open versus Percutaneous Techniques for Primary Mid-Substance Achilles Tendon Repair: A Meta-Analysis
poste
Spin effects in a confined 2DEG: Enhancement of the g-factor, spin-inversion states and their far-infrared absorption
We investigate several spin-related phenomena in a confined two-dimensional
electron gas (2DEG) using the Hartree-Fock approximation for the mutual Coulomb
interaction of the electrons. The exchange term of the interaction causes a
large splitting of the spin levels whenever the chemical potential lies within
a Landau band (LB). This splitting can be reinterpreted as an enhancement of an
effective g-factor, g*. The increase of g* when a LB is half filled can be
accompanied by a spontaneous formation of a static spin-inversion state (SIS)
whose details depend on the system sision state (SIS) whose details depend on
the system size. The coupling of the states of higher LB's into the lowest band
by the Coulomb interaction of the 2DEG is essential for the SIS to occur. The
far-infrared absorption of the system, relatively insensitive to the spin
splitting, develops clear signs of the SIS.Comment: 7 figure
Histological evaluation of microfilled and conventional composite resins on monkey dental pulps
The pulpal responses to two micro-filled composite resins and a conventional composite resin were investigated in adult rhesus monkey teeth. All materials were randomly placed in unetched and unlined class V buccal cavity preparations. A total of 90 teeth were used in the study. Each material was evaluated at 3 days, 5 weeks and 8 weeks. Following perfusion, the teeth were prepared using routine histological procedures. The results indicated that the pulpal response to the microfilled and conventional composite resins were similar for all time periods, characterized by an initial slight to moderate response at 3 days, followed at 5 and 8 weeks by a zero to slight response with evidence of reparative dentine formation. Brown and Brenn staining for bacteria indicated positive staining reactions along the cavity wails of all teeth for all materials at each time period.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73366/1/j.1365-2591.1985.tb00453.x.pd
Affect in mathematics education
There are two different uses for the word “affect” in behavioral sciences. Often it is used as an overarching umbrella concept that covers attitudes, beliefs, motivation, emotions, and all other noncognitive aspects of human mind. In this article, however, the word affect is used in a more narrow sense, referring to emotional states and traits. A more technical definition of emotions, states, and traits will follow later.Peer reviewe
Anxiety is not enough to drive me away: A latent profile analysis on math anxiety and math motivation
Mathematics anxiety (MA) and mathematics motivation (MM) are important multi-dimensional non-cognitive factors in mathematics learning. While the negative relation between global MA and MM is well replicated, the relations between specific dimensions of MA and MM are largely unexplored. The present study utilized latent profile analysis to explore profiles of various aspects of MA (including learning MA and exam MA) and MM (including importance, self-perceived ability, and interest), to provide a more holistic understanding of the math-specific emotion and motivation experiences. In a sample of 927 high school students (13–21 years old), we found 8 distinct profiles characterized by various combinations of dimensions of MA and MM, revealing the complexity in the math-specific emotion-motivation relation beyond a single negative correlation. Further, these profiles differed on mathematics learning behaviors and mathematics achievement. For example, the highest achieving students reported modest exam MA and high MM, whereas the most engaged students were characterized by a combination of high exam MA and high MM. These results call for the need to move beyond linear relations among global constructs to address the complexity in the emotion-motivation-cognition interplay in mathematics learning, and highlight the importance of customized intervention for these heterogeneous groups
The Ergogenic Potential of Arginine
Arginine is a conditionally essential amino acid that is involved in protein synthesis, the detoxification of ammonia, and its conversion to glucose as well as being catabolized to produce energy. In addition to these physiological functions, arginine has been purported to have ergogenic potential. Athletes have taken arginine for three main reasons: 1) its role in the secretion of endogenous growth hormone; 2) its involvement in the synthesis of creatine; 3) its role in augmenting nitric oxide. These aspects of arginine supplementation will be discussed as well as a review of clinical investigations involving exercise performance and arginine ingestion
Unconventional applications of wire bonding create opportunities for microsystem integration
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