SISTEMA DE INFORMAÇÃO GEOGRÁFICA COMO FERRAMENTA AUXILIAR NO PROCESSO DE GESTÃO DAS UNIVERSIDADES

A coleta de informações sobre fenômenos que possuem distribuição geográfica é importante, pois permite localizar pontos dentro de um determinado espaço e fazer análises localizacionais. A utilização deste tipo de informação tem sido amplamente utilizada para auxiliar no planejamento de tomada de decisões de diversas empresas, e mais recentemente vem sendo adotada por alguns órgãos da gestão pública, devido a sua eficiência. Este trabalho tem como objetivo criar um Sistema de Informação Geográfica (SIG) do Campus da UFES, localizado em Alegre/ES, afim de que o mesmo sirva como ferramenta de gestão para tomada de decisões. O trabalho será iniciado com o levantamento de dados qualitativos, destacando as principais características de cada edificação construída e sua ocupação no tempo, em seguida serão utilizadas técnicas de pesquisa bibliográfica e documental a fim de respaldar as discussões sobre o tema proposto. Por fim, será elaborado um banco de dados em SIG com todas as informações relativas ao local. A área de estudo compreende o campus da Universidade Federal do Espírito Santo UFES, localizado em Alegre -ES, que foi contemplado pelos planos de extensão do governo e teve sua área construída aumentada no período de 2004 a 2014. A falta de um planejamento adequado na localização dessas obras causa diversos problemas ao campus, como falta de vagas nos estacionamentos, salas de aulas em quantidade e tamanhos insuficientes, áreas verdes de pequenas proporções, dentre outros. A confecção do banco de dados espacial, produto final que se pretende alcançar com esse projeto de dissertação, permitirá minimizar futuros impactos a partir das decisões conscientes da gestão. A proposta enquadra-se na linha de pesquisa Gestão de Operações do Setor Público, na qual a orientadora deste trabalho está alocada. Palavras-chave: banco de dados geográfico; gestão universitária; mapeamento; universidades federais; programas de expansão universitária

Risk stratification for covert invasive cancer among patients referred for colonic endoscopic mucosal resection: a large multicenter cohort

Background & Aims Among patients with large colorectal sessile polyps or laterally spreading lesions, it is important to identify those at risk for submucosal invasive cancer (SMIC). Lesions with overt endoscopic evidence of SMIC are referred for surgery, although those without these features might still contain SMIC that is not visible on endoscopic inspection (covert SMIC). Lesions with a high covert SMIC risk might be better suited for endoscopic submucosal dissection than for endoscopic mucosal resection (EMR). We analyzed a group of patients with large colon lesions to identify factors associated with SMIC, and examined lesions without overt endoscopic high-risk signs to determine factors associated with covert SMIC. Methods We performed a prospective cohort study of consecutive patients referred for EMR of large sessile or flat colorectal polyps or laterally spreading lesions (≥20 mm) at academic hospitals in Australia from September 2008 through September 2016. We collected data on patient and lesion characteristics, outcomes of procedures, and histology findings. We excluded serrated lesions from the analysis of covert SMIC due to their distinct phenotype and biologic features. Results We analyzed 2277 lesions (mean size, 36.9 mm) from 2106 patients (mean age, 67.7 years; 53.2% male). SMIC was evident in 171 lesions (7.6%). Factors associated with SMIC included Kudo pit pattern V, a depressed component (0–IIc), rectosigmoid location, 0–Is or 0–IIa+Is Paris classification, non-granular surface morphology, and increasing size. After exclusion of lesions that were obviously SMIC or serrated, factors associated with covert SMIC were rectosigmoid location (odds ratio, 1.87; P =.01), combined Paris classification, surface morphology (odds ratios, 3.96−22.5), and increasing size (odds ratio, 1.16/10 mm; P =.012). Conclusions In a prospective study of 2106 patients who underwent EMR for large sessile or flat colorectal polyps or laterally spreading lesions, we associated rectosigmoid location, combined Paris classification and surface morphology, and increasing size with increased risk for covert malignancy. Rectosigmoid 0–Is and 0–IIa+Is non-granular lesions have a high risk for malignancy, whereas proximally located 0–Is or 0–IIa granular lesions have a low risk. These findings can be used to inform decisions on which patients should undergo endoscopic submucosal dissection, EMR, or surgery. ClinicalTrials.gov, Number: NCT02000141

IFN-λ3, not IFN-λ4, likely mediates IFNL3–IFNL4 haplotype–dependent hepatic inflammation and fibrosis

The International Liver Disease Genetics Consortium (ILDGC).Genetic variation in the IFNL3–IFNL4 (interferon-λ3–interferon-λ4) region is associated with hepatic inflammation and fibrosis1,2,3,4. Whether IFN-λ3 or IFN-λ4 protein drives this association is not known. We demonstrate that hepatic inflammation, fibrosis stage, fibrosis progression rate, hepatic infiltration of immune cells, IFN-λ3 expression, and serum sCD163 levels (a marker of activated macrophages) are greater in individuals with the IFNL3–IFNL4 risk haplotype that does not produce IFN-λ4, but produces IFN-λ3. No difference in these features was observed according to genotype at rs117648444, which encodes a substitution at position 70 of the IFN-λ4 protein and reduces IFN-λ4 activity, or between patients encoding functionally defective IFN-λ4 (IFN-λ4–Ser70) and those encoding fully active IFN-λ4–Pro70. The two proposed functional variants (rs368234815 and rs4803217)5,6 were not superior to the discovery SNP rs12979860 with respect to liver inflammation or fibrosis phenotype. IFN-λ3 rather than IFN-λ4 likely mediates IFNL3–IFNL4 haplotype–dependent hepatic inflammation and fibrosis.M.E., M.D., and J.G. are supported by the Robert W. Storr Bequest to the Sydney Medical Foundation, University of Sydney, and by a National Health and Medical Research Council of Australia (NHMRC) Program Grant (1053206) and NHMRC Project Grants (APP1107178 and APP1108422). G.D. is supported by an NHMRC Fellowship (1028432)

IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis

Genetic variation in the IFNL3-IFNL4 (interferon-λ3-interferon-λ4) region is associated with hepatic inflammation and fibrosis. Whether IFN-λ3 or IFN-λ4 protein drives this association is not known. We demonstrate that hepatic inflammation, fibrosis stage, fibrosis progression rate, hepatic infiltration of immune cells, IFN-λ3 expression, and serum sCD163 levels (a marker of activated macrophages) are greater in individuals with the IFNL3-IFNL4 risk haplotype that does not produce IFN-λ4, but produces IFN-λ3. No difference in these features was observed according to genotype at rs117648444, which encodes a substitution at position 70 of the IFN-λ4 protein and reduces IFN-λ4 activity, or between patients encoding functionally defective IFN-λ4 (IFN-λ4-Ser70) and those encoding fully active IFN-λ4-Pro70. The two proposed functional variants (rs368234815 and rs4803217) were not superior to the discovery SNP rs12979860 with respect to liver inflammation or fibrosis phenotype. IFN-λ3 rather than IFN-λ4 likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis

The histological features of intestinal spirochetosis in a series of 113 patients.

A multicenter retrospective review of cases diagnosed as spirochetosis was performed to determine the presenting symptoms and histological changes. A total of 113 cases were retrieved from the archives, comprising 97 colorectal specimens and 16 appendices. In only 25 cases was the presenting symptom recorded as diarrhea. Of the colorectal specimens, 87 (90%) showed no mucosal abnormality (apart from the spirochetes); the other 10 showed mucosal inflammation but 6 of them had a diagnosis of another inflammatory disease process accounting for the inflammatory changes. Five appendices showed acute appendicitis; the other 11 were unremarkable. We conclude that spirochetosis in an unselected general population is unlikely to be of pathological significance. Furthermore, if spirochetosis is observed in an inflamed biopsy, it is most likely to be an incidental finding

Nesidioblastosis following laparoscopic sleeve gastrectomy

Hyperinsulinaemic hypoglycaemia due to nesidioblastosis after bariatric surgery is a rare but well‐documented complication of rouxen‐ Y gastric bypass (RYGB). We report the first documented case of nesidioblastosis following laparoscopic sleeve gastrectomy. This is a timely report as sleeve gastrectomy is now the most commonly performed bariatric procedure, accounting for 52.5% of bariatric procedures performed in Australia between 2014 and 2015.1 This case is important as nesidioblastosis is not a previously reported complication of sleeve gastrectomy. It therefore expands our understanding of the effect of surgically induced changes to incretin secretion following sleeve gastrectomy

Usefulness of smears in intra-operative diagnosis of newly described entities of CNS: Review Article

The recent edition of World Health Organisation (WHO) Classification of Tumours of the Central Nervous System has incorporated a substantial number of important changes. It has recognised several new entities, many of which are rare. Intra-operative diagnosis of these tumours can be difficult with the freezing artefact that often cripples brain frozen sections. In many instances intra-operative smears are extremely useful adjuvants in neuropathological diagnosis. In this article, we describe intra-operative smear findings of three of the newly described tumours. Their characteristic cytologic features are illustrated along with differentiating features from the common mimics, together with a general approach to brain smears. The entities we discuss here are papillary glioneuronal tumour, papillary tumour of the pineal region and angiocentric glioma. All three tumours share at least focal pseudo-papillary/ vasculocentric architecture. Smears from papillary glioneuronal tumour demonstrated dual population of cells in a neuropil background, whereas papillary tumour of the pineal region and angiocentric glioma comprise a single population of cells. These two tumours can further be differentiated based on their cell morphology and background. © 2009 Japanese Society of Neuropathology.link_to_subscribed_fulltex

A comparative study of retention of complete denture base with different types of posterior palatal seals – an in vivo study

GS Chandu,1 BS Hema,2 Harsh Mahajan,1 Antriksh Azad,2 Ipsita Sharma,3 Anurag Azad4 1Department of Prosthodontics, Rishiraj College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India; 2Department of Conservative Dentistry, Rishiraj College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India; 3Department of Oral Pathology, RKDF Dental college and Research centre, Bhopal, Madhya Pradesh, India; 4Department of Oral and Maxillofacial Surgery, Bhabha College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India Aim: To evaluate retention of complete denture base with different types of posterior palatal seals. Material and methods: Ten male patients between the age group of 50 years to 60 years were selected for the study. After the primary and secondary impressions were taken, five casts were made including a cast without posterior palatal seal, a cast with single bead posterior palatal seal, a cast with double bead posterior palatal seal, a cast with butterfly shaped posterior palatal seal, and a cast with posterior palatal seal with low fusing compound by functional method. Results: It was observed that retention increased up to 108% in the posterior palatal seal with low fusing compound with functional method and the posterior palatal seal that was obtained by using functional method provided greater retention than a denture base without posterior palatal seal. Conclusion: It was concluded that the incorporation of a posterior palatal seal is important for obtaining optimum retention of the maxillary complete denture. Keywords: posterior palatal seal, denture base, complete denture, functional metho