Werking, bijwerking en de balans

See p. 20 of Lectur

Water Management Solution of Reservoir Storage Function Under Condition of Measurement Uncertainties in Hydrological Input Data

AbstractThe paper describes a possible procedure of the rate uncertainty implementation to the continuous water stage measurement and uncertainties of state - discharge rating curve point positions, which the stage -discharge rating curves were fitted into the uncertainties of the real discharge series members. Then the members of discharge series under uncertainty impact were tested on the calculated values of the reservoir storage volume. The next step was the implementation of the uncertainties of the real discharge series members on the generation of the artificial discharge series of mean monthly discharge using the AR and ARMA generators and the determination of their impact on the calculated values of the reservoir storage volume

Werking, bijwerking en de balans

See p. 20 of Lectur

Not only randomised controlled trials, but also controlled observational studies

Technology assessment of reproductive medicin

Is an EMA review on hormonal contraception and thrombosis needed?

Technology assessment of reproductive medicin

HORMONAL CONTRACEPTION AND THROMBOSIS Authors' reply to Costescu and Waddington

Clinical epidemiolog

Reply: Difficult intrauterine device insertion

Cervix cance

The Risk of Deep Venous Thrombosis Associated With Injectable Depot-Medroxyprogesterone Acetate Contraceptives or a Levonorgestrel Intrauterine Device

Objective-To assess the risk of venous thrombosis associated with nonoral contraceptives (ie, injectable depot-medroxyprogesterone acetate contraceptives, hormone [levonorgestrel]-releasing intrauterine devices, a contraceptive patch, or a contraceptive implant). Methods and Results-Analyses were performed in the Multiple Environmental and Genetic Assessment study, a large case-control study on risk factors for venous thrombosis. For the current analyses, we selected premenopausal women, aged 18 to 50 years, who were not pregnant nor within 4 weeks postpartum and were not using oral contraceptives; 446 patients and 1146 controls were included. Injectable depot-medroxyprogesterone acetate contraceptives were associated with a 3.6-fold (95% CI, 1.8- to 7.1-fold) increased risk of venous thrombosis compared with nonusers of hormonal contraceptives. The use of a levonorgestrel intrauterine device was not associated with an increased risk (odds ratio, 0.3; 95% CI, 0.1 to 1.1). Unfortunately, the few women using a contraceptive patch or an implant prevented a reliable estimate of the risk of thrombosis. Conclusion-The risk of venous thrombosis was increased for injectable depot-medroxyprogesterone acetate contraceptive users, while we were able to reliably exclude an increased risk associated with levonorgestrel intrauterine device use. Therefore, the latter seems to be the safest option regarding the risk of venous thrombosis. (Arterioscler Thromb Vasc Biol. 2010;30:2297-2300.)Cervix cance

Oral contraceptives containing drospirenone for premenstrual syndrome

Technology assessment of reproductive medicin