Measuring Perceived Realistic Physical Threat Imposed by Migrants: Scale Development and Validation

Individuals differ in the extent to which they perceive threat imposed by out-groups like migrants. An established distinction in intergroup threat research is between symbolic and realistic threat. While symbolic threats concern a perceived menace against societal values, realistic threats jeopardize in-group members’ well-being more directly. Typically applied realistic threat conceptions explicitly include the aspect of physical integrity, but most empirical research captures only realistic economic threats, arguably also due to a lack of appropriate measures. Therefore, we have developed the Perceived Realistic Physical Threat scale (PRPT) with samples from Germany and the UK (total N = 1,391). Moreover, we conducted follow-up analyses with data from a subsample (N = 473) of the initial UK sample. Factor analyses indicated an 8-item one-factorial solution for the PRPT scale. We further identified measurement invariance across samples and over time and stability across 21 months. We found convincing evidence for its convergent and divergent validity and for its predictive and, importantly, incremental validity, above and beyond the prediction of relevant criteria by other threat types. The PRPT scale appears to be a distinct, comprehensive, and psychometrically sound measure of perceived realistic physical threat, complementing the existing body of available measures

Climate of Hate: Similar Correlates of Far Right Electoral Support and Right-Wing Hate Crimes in Germany

Rees J, Rees Y, Hellmann JH, Zick A. Climate of Hate: Similar Correlates of Far Right Electoral Support and Right-Wing Hate Crimes in Germany. Frontiers in Psychology. 2019;10: 2328.Since 2015, far right parties drawing heavily on radical anti-refugee rhetoric gained electoral support in Germany while the number of political hate crimes targeting refugees rose. Both phenomena – far right electoral support and prevalence of right-wing hate crimes – have theoretically and empirically been linked with socio-structural and contextual variables. However, systematic empirical research on these links is scattered and scarce at best. We combine official statistics on political hate crimes targeting refugees in Germany and far right electoral support of the far right party “Alternative für Deutschland” (AfD) in the German national elections 2017 with socio-structural variables (proportion of foreigners and unemployment rate) and survey data collected in a representative survey (N = 1,506) in 2016. We aggregate and combine data for all German municipalities except Berlin which were the level of analysis for the current study. In path analyses, we find socio-structural variables to be unrelated with each other but significantly correlated with both criterion variables in a systematic fashion: proportion of foreigners was negatively while unemployment rate was positively linked with far right electoral support. Right-wing crime was linked positively with unemployment rate across Germany and positively with proportion of foreigners only in East Germany while proportion of foreigners was unrelated to right-wing crime in West Germany. When including survey measures into the model, they were linked with socio-structural variables in the predicted fashion – intergroup contact correlated positively with proportion of foreigners, collective deprivation correlated positively with unemployment rates, and both predicted extreme right-wing attitudes. However, their contribution to the explained variance in outcome variables above and beyond socio-structural variables was neglectable. We argue that both far right-wing electoral support and right-wing hate crime can be conceptualized as behavioral forms of political extremism shaped through socio-structural and contextual factors and discuss implications for preventing political extremism

Ugandan and British individuals' views of refugees in their countries: An exploratory <scp>mixed‐methods</scp> comparison

Abstract: Using an exploratory mixed‐methods approach, we examined thoughts concerning refugees reported by participants from a non‐Western country, Uganda, and the United Kingdom (total N = 113). We explored whether, due to various sociocultural, political and geographic differences, critical features of refugee migration (e.g., migration forcedness and migration‐related perils) would be viewed differently by Ugandan and UK participants. An inductive qualitative content analysis of responses in an online survey yielded 11 categories with 40 subcategories revealing several similarities between Ugandan and UK participants. For instance, similar proportions of participants from both countries acknowledged refugees' suffering before their migration and the forced nature of refugees' migration. However, we also found that more British than Ugandan participants referred to perils refugees suffer during their journeys, possibly resulting from differences in refugees' migration routes (e.g., crossing other countries, travelling by dilapidated boats, migration duration). Furthermore, Ugandan but not British participants took pride in international praise their country received for its forthcoming treatment of refugees. There were no differences regarding the extent to which Ugandan and British individuals exhibited prejudice towards refugees or experienced threats from refugees. We discuss the theoretical and practical implications of our findings for refugee integration

No effect of the turmeric root phenol curcumin on prednisolone-induced glucometabolic perturbations in men with overweight or obesity

Objectives: Preclinically, curcumin has been shown to protect against glucocorticoid-induced insulin resistance. We evaluated the effect of curcumin administered with prednisolone in healthy overweight or obese men. Methods: In a double-blind, parallel-group trial, 24 overweight/obese non-diabetic men were randomised to one of three intervention groups (A) prednisolone placebo+curcumin placebo, (B) prednisolone (50 mg/day)+curcumin placebo or (C) prednisolone and curcumin (400 mg/day). Curcumin or curcumin placebo treatment started 1 day prior to 10-day prednisolone or prednisolone placebo treatment. The primary endpoint was change in prednisolone-induced insulin resistance assessed by homeostatic model assessment of insulin resistance (HOMA2-IR). Other endpoints included anthropometric measurements, magnetic resonance spectroscopy-assessed hepatic fat content, blood pressure, circulating metabolic markers and continuous glucose monitoring measures. Results: Baseline characteristics (mean ± s.d): age 44.2 ± 13.7 years, BMI 30.1 ± 3.5 kg/m2, HbAlc 33.3 ± 3.2 mmol/mol, HOMA2-IR 1.10 ± 0.45 and fasting plasma glucose 5.2 ± 0.4 mmol/L. Prednisolone significantly increased HOMA2-IR (estimated treatment difference 0.36 (95% CI 0.16; 0.57)). Co-treatment with curcumin had no effect on HOMA2-IR (estimated treatment difference 0.08 (95% CI −0.13; 0.39)). Prednisolone increased HbAlc, insulin, C-peptide, glucagon, blood pressure, mean interstitial glucose, time spent in hyperglycaemia and glucose variability, but no protective effect of curcumin on any of these measures was observed. Conclusions: In this double-blind, placebo-controlled parallel-group study involving 24 overweight or obese men randomised to one of three treatment arms, curcumin treatment had no protective effect on prednisolone-induced insul in resistance or other glucometabolic perturbations

Impact of age on efficacy and toxicity of nilotinib in patients with chronic myeloid leukemia in chronic phase : ENEST1st subanalysis

Purpose Achievement of deep molecular response with a tyrosine kinase inhibitor in patients with chronic myeloid leukemia (CML) is required to attempt discontinuation of therapy in these patients. The current subanalysis from the Evaluating Nilotinib Efficacy and Safety in Clinical Trials as First-Line Treatment (ENEST1st) study evaluated whether age has an impact on the achievement of deeper molecular responses or safety with frontline nilotinib in patients with CML. Methods ENEST1st is an open-label, multicenter, single-arm, prospective study of nilotinib 300 mg twice daily in patients with newly diagnosed CML in chronic phase. The patients were stratified into the following 4 groups based on age: young (18-39 years), middle age (40-59 years), elderly (60-74 years), and old (>= 75 years). The primary end point was the rate of molecular response 4 ([MR4] BCR-ABL1 Results Of the 1091 patients enrolled, 1089 were considered in the analysis, of whom, 23% (n = 243), 45% (n = 494), 27% (n = 300), and 5% (n = 52) were categorized as young, middle age, elderly, and old, respectively. At 18 months, the rates of MR4 were 33.9% (95% confidence interval [CI], 27.8-40.0%) in the young, 39.6% (95% CI, 35.3-44.0%) in the middle-aged, 40.5% (95% CI, 34.8-46.1%) in the elderly, and 35.4% (95% CI, 21.9-48.9%) in the old patients. Although the incidence of adverse events was slightly different, no new specific safety signals were observed across the 4 age groups. Conclusions This subanalysis of the ENEST1st study showed that age did not have a relevant impact on the deep molecular response rates associated with nilotinib therapy in newly diagnosed patients with CML and eventually on the eligibility of the patients to attempt treatment discontinuation.Peer reviewe

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Heading right and judging harsher: Spatial orientation toward the right side and moral judgments

Glaser T, Hellmann JH. Heading right and judging harsher: Spatial orientation toward the right side and moral judgments. Social Psychology. 2017;48(5):253-264.The term right may imply different meanings, for example, right can be the direction opposite to left, but right can also mean the opposite of wrong. In three experiments, we investigated whether orientation toward the right versus left direction can influence how individuals judge situational moral transgressions. Mental spatial orientation was manipulated by placing the text of moral transgressions on the left versus right side of the screen (Experiment 1) or by presenting different landscape pictures depicting paths that either lead to the left versus to the right (Experiments 2 and 3). In Experiment 3, we also manipulated participants' physical spatial orientation. Results confirmed our main prediction that a mental rightward (vs. leftward) orientation can trigger relatively harsher moral judgments