Time trends in the epidemiology of renal transplant patients with type 1 diabetes mellitus over the last four decades

Background. Diabetes mellitus (DM) type 1 is an important contributor to end-stage renal disease (ESRD) among younger transplant recipients. However, little is known about the changes in epidemiological characteristics of this population. Especially, time to reach ESRD may have changed in type 1 diabetic patients referred for transplantation, resulting in higher age at time of grafting. Such time trends may allow anticipating future developments regarding the demand for organ replacement in this patient group. Methods. We retrospectively analysed 173 patients with type 1 DM undergoing renal transplantation at our institution, stratified into four groups according to year of reaching ESRD (A = 1973-1983, B = 1984-1990, C = 1991-1995 and D = 1996-2002). For each group we determined age at diagnosis of DM, age at time of reaching ESRD and age at time of transplantation. From these data, the interval from diagnosis of DM to ESRD and from ESRD to transplantation was calculated. The results were analysed in relation to gender, year of and age at onset of diabetes. Results. Patients reaching ESRD in more recent years (group D) tended to be both younger at diagnosis of DM and older when reaching ESRD, resulting in higher mean age at transplantation (35.0, 37.5, 39.6 and 41.0 years in groups A, B, C and D, respectively). Accordingly, median duration to ESRD has significantly been prolonged over the last five decades in patients with type 1 DM undergoing renal transplantation (group A: 21.0, B: 20.7, C: 22.3 and D: 28.5 years; P<0.0001), this finding being more pronounced in female patients. Conclusions. The results of our analysis are compatible with a change in epidemiology in patients undergoing kidney transplantation. Older age at time of reaching ESRD may impact significantly on the demand for renal grafts, as patients are already clearly older nowadays when being transplanted. From our data it cannot be concluded whether this development is due to a change in the progression of diabetic nephropathy or may simply reflect a change in the selection of type 1 diabetic patients referred for transplantatio

Exact solution of the Zeeman effect in single-electron systems

Contrary to popular belief, the Zeeman effect can be treated exactly in single-electron systems, for arbitrary magnetic field strengths, as long as the term quadratic in the magnetic field can be ignored. These formulas were actually derived already around 1927 by Darwin, using the classical picture of angular momentum, and presented in their proper quantum-mechanical form in 1933 by Bethe, although without any proof. The expressions have since been more or less lost from the literature; instead, the conventional treatment nowadays is to present only the approximations for weak and strong fields, respectively. However, in fusion research and other plasma physics applications, the magnetic fields applied to control the shape and position of the plasma span the entire region from weak to strong fields, and there is a need for a unified treatment. In this paper we present the detailed quantum-mechanical derivation of the exact eigenenergies and eigenstates of hydrogen-like atoms and ions in a static magnetic field. Notably, these formulas are not much more complicated than the better-known approximations. Moreover, the derivation allows the value of the electron spin gyromagnetic ratio $g_s$ to be different from 2. For completeness, we then review the details of dipole transitions between two hydrogenic levels, and calculate the corresponding Zeeman spectrum. The various approximations made in the derivation are also discussed in details.Comment: 18 pages, 4 figures. Submitted to Physica Script

Compactification near and on the light front

We address problems associated with compactification near and on the light front. In perturbative scalar field theory we illustrate and clarify the relationships among three approaches: (1) quantization on a space-like surface close to a light front; (2) infinite momentum frame calculations; and (3) quantization on the light front. Our examples emphasize the difference between zero modes in space-like quantization and those in light front quantization. In particular, in perturbative calculations of scalar field theory using discretized light cone quantization there are well-known ``zero-mode induced'' interaction terms. However, we show that they decouple in the continuum limit and covariant answers are reproduced. Thus compactification of a light-like surface is feasible and defines a consistent field theory.Comment: 24 pages, 4 figure

Tritium concentration measurements in the JET divertor by optical spectroscopy of a Penning discharge

Obtaining precision measurements of the relative concentrations of hydrogen, deuterium, tritium, and helium in the divertor of a tokamak are an important task for nuclear fusion research. Control of the deuterium-tritium isotopic ratio while limiting the helium ash content in a fusion plasma are key factors for optimizing the fuel burn in a fusion reactor, like the International Tokamak Experimental Reactor (ITER). A diagnostic technique has been developed to measure the deuterium-tritium isotopic ratio in the divertor of the Joint European Torus (JET) with a species-selective Penning vacuum gauge. The Penning discharge provides a source of electrons to excite the neutral hydrogen isotopes in the pumping duct. Subsequently, the visible light from the hydrogen isotopes is collected in an optical fiber bundle, transferred away from the tokamak into a low radiation background area, and analyzed in a high resolution Czerny-Turner spectrometer, which is equipped with a fast charge coupled device (CCD) camera for optical detection. The intensity of the observed line emission (D{sub {alpha}} -- 6561.03 {angstrom}; and T{sub {alpha}} -- 6560.44 {angstrom}) is directly proportional to the partial pressure of each gas found in the divertor. The line intensity of each isotope is calibrated as a function of pressure. The ratio of the line intensities thus provides a direct measurement of the deuterium-tritium isotopic ratio. The lower limit for the determination of the deuterium-tritium isotopic ratio is about 0.5%. The applicable pressure range for this system is from 10{sup {minus}5} mbar to a few times 10{sup {minus}3} mbar