The Journey of Grief Campaign: An Analysis of Qui Nguyen\u27s play; She Kills Monsters

The Journey of Grief Campaign; An Analysis of Qui Nguyen play She Kills Monsters Eve Helak Qui Nguyen\u27s work She Kills Monsters is an exceptional example of keeping your audience entertained and in tears. The play is centered around a woman named Agnes, discovering and participating in her recently deceased, younger sisters Dungeons & Dragons campaign. Through Agnes’ fantasy filled journey, she undergoes each stage of grief through the game’s monsters and cast of characters, which allows an understanding and acceptance for her sister’s tragedy. Through its mystical yet utterly grounded lens, She Kills Monsters both entertains and accomplishes its potent themes of grief, and can be surveyed through my analysis of the text

Book donations for the University Library in Poznań in the years 1921–1927

Artykuł dotyczy darów dla Biblioteki Uniwersyteckiej w Poznaniu, które wpłynęły do niej w latach 1921–1927. Biblioteka Uniwersytecka powstała w 1919 roku na gruncie dotychczasowej Biblioteki im. Cesarza Wilhelma. Księgozbiór liczący 270 000 tomów miał charakter ogólnoświatowy i germanizacyjny. Ważnym i odpowiedzialnym zadaniem dyrektora Biblioteki Uniwersyteckiej dr. Edwarda Kuntzego stała się polonizacja i dostosowanie istniejącego księgozbioru do nowo powstałego Uniwersytetu Poznańskiego. Dzięki wielkiej ofiarności różnych instytucji krajowych i zagranicznych oraz osób prywatnych udało się zbudować solidny księgozbiór naukowy. Zbiory biblioteczne zostały wzbogacone przez m.in. cenny zbiór książek ze zlikwidowanych rosyjskich bibliotek gimnazjalnych w Kaliszu, księgozbiór prof. Erazma Majewskiego z Warszawy, dr. Leona Szumana z Torunia, dr. Władysława Falgowskiego, prof. Tadeusza Ulatowskiego, prof. Aleksandra Zalewskiego, Władysława Reymonta. Kończąc swoją owocną działalność w Bibliotece Uniwersyteckiej w 1927 roku, Kuntze pozostawił księgozbiór liczący 352 000 tomów.The present article discusses the donations for the University Library in Poznań received by the library between 1921–1927. The University Library originated in 1919, after taking over the collections of the former German Kaiser Wilhelm Bibliothek. The book stock of the latter, amounting to 270,000 volumes, had a general character and was designed to promote German science and culture. In this situation it was an important and sensitive task for the director of the University Library Dr. Edward Kuntze to carry on with Polonisation of the library’s collections and to streamline the existing collections with the needs of the newly established University of Poznań. Thanks to the following generosity and dedication of various institutions at home and abroad, as well as to donations made by private persons, it was possible to create a sizeable collection of academic and research books. The library’s collections were successively enriched with valuable book collections from dissolved Russian gymnasium libraries in Kalisz and private book collections of Prof. Majewski from Warsaw, Dr. Szuman from Toruń, Dr. Falgowski and Prof. Ulatowski, Prof. Zalewski, and Władysław Reymont, among others. In 1927, when Dr. Kunze retired from the Library, its book collections amounted to 352,000 volumes

Profesor Aleksander Birkenmajer jako dyrektor Biblioteki Uniwersyteckiej w Poznaniu w latach 1939–1947

This article presents the pre-war director of the University Library in Poznań, Prof. Aleksander Birkenmajer, to commemorate this year’s 50th anniversary of Birkenmajer’s death. Prof. Birkenmajer took the reins of the University Library in March 1939, shortly before the outbreak of WW II. During the occupation, Birkenmajer was released of his duties and did not see his co-workers for a number of years. He came back to the Library in March 1945 to re-establish and commence regular duties of the institution between 1945–1947. The present article is based on the archival materials currently kept in the Archives of the University Library in Poznań.Artykuł przedstawia profesora Aleksandra Birkenmajera, przedwojennego dyrektora Biblioteki Uniwersyteckiej w Poznaniu. Okazją do jego przypomnienia jest przypadająca w 2017 roku 50. rocznica śmierci. Kierownictwo Biblioteki Uniwersyteckiej rozpoczął w marcu 1939 roku, tuż przed wybuchem II wojny światowej. Podczas okupacji na kilka lat rozstał się ze współpracownikami. Do Biblioteki Uniwersyteckiej w Poznaniu powrócił w marcu 1945 roku, aby uczestniczyć w niezwykle trudnej odbudowie życia bibliotecznego w latach 1945–1947. Do napisania artykułu zostały wykorzystane materiały archiwalne zachowane w Archiwum Biblioteki Uniwersyteckiej w Poznaniu

Polysaccharides and mucin 5AC (MUC5AC) expression in gallbladder mucosa of young patients with gallstones as evaluated by spatial visualization and quantification

The study aimed at examination of tissue expression of polysaccharides and secretory mucin 5AC (MUC5AC)in young patients (up to 25 years of age) with a symptomatic gallstones. For comparison, patients most frequently subjectedto cholecystectomy were studied, i.e. patients of approximately 50 years of age with the same diagnosis. In quantitativestudies on tissue expression of both mucus components, the modern technique of spatial visualization was applied for thefirst time. Application of the technique permitted to demonstrate significant positive relationships between expression ofglycoproteins (immunocytochemical ABC technique for detection of MUC5AC) and expression of sugar components inmucus (PAS technique) and to confirm suitability of the technique for quantitative appraisal of both histochemical andimmunocytochemical reactions. An even higher expression of polysaccharides in the entire mucosa and of MUC5AC wasdetected in gallbladder epithelium of 50-year-old patients, as compared to young patients with symptomatic gallstones. Inthe young patients, expression of polysaccharides correlated with inflammatory activity (grading), width of gallbladder walland PLT level in peripheral blood. A significantly higher expression of polysaccharides in gallbladder epithelium wasdemonstrated in young patients admitted in the emergency mode to the hospital. These correlations in young patients maysuggest a role of both mucus components in pathogenesis of cholelithiasis in this age group. A quantitative appraisal ofmucus component expression in the two parts of gallbladder mucosa (epithelium vs. entire mucosa) using spatial visualizationtechnique permitted to more accurately compare production of glycoproteins and of polysaccharides in patients withcholelithiasis and to demonstrate additional correlations of a potential clinical significance

Polysaccharides and mucin 5AC (MUC5AC) expression in gallbladder mucosa of young patients with gallstones as evaluated by spatial visualization and quantification.

The study aimed at examination of tissue expression of polysaccharides and secretory mucin 5AC (MUC5AC) in young patients (up to 25 years of age) with a symptomatic gallstones. For comparison, patients most frequently subjected to cholecystectomy were studied, i.e. patients of approximately 50 years of age with the same diagnosis. In quantitative studies on tissue expression of both mucus components, the modern technique of spatial visualization was applied for the first time. Application of the technique permitted to demonstrate significant positive relationships between expression of glycoproteins (immunocytochemical ABC technique for detection of MUC5AC) and expression of sugar components in mucus (PAS technique) and to confirm suitability of the technique for quantitative appraisal of both histochemical and immunocytochemical reactions. An even higher expression of polysaccharides in the entire mucosa and of MUC5AC was detected in gallbladder epithelium of 50-year-old patients, as compared to young patients with symptomatic gallstones. In the young patients, expression of polysaccharides correlated with inflammatory activity (grading), width of gallbladder wall and PLT level in peripheral blood. A significantly higher expression of polysaccharides in gallbladder epithelium was demonstrated in young patients admitted in the emergency mode to the hospital. These correlations in young patients may suggest a role of both mucus components in pathogenesis of cholelithiasis in this age group. A quantitative appraisal of mucus component expression in the two parts of gallbladder mucosa (epithelium vs. entire mucosa) using spatial visualization technique permitted to more accurately compare production of glycoproteins and of polysaccharides in patients with cholelithiasis and to demonstrate additional correlations of a potential clinical significance

Analysis of immunohistochemical expression of proinflammatory cytokines (IL-1α, IL-6, and TNF-α) in gallbladder mucosa: comparative study in acute and chronic calculous cholecystitis

Background: Several studies have shown increased serum levels of proinflammatory cytokines (IL-1α, IL-6, and TNF-α) in patients with cholelithiasis. The local expression of the proteins involved in pathogenesis of the disease is poorly recognised. Materials and methods: The authors examined immunohistochemically (IHC) the expression status of IL-1α, IL-6, and TNF-α in gallbladder mucosa of the patients with cholelithiasis as related to acute (ACC) and chronic (CCC) types of cholecystitis. Proinflammatory cytokines were quantitatively evaluated in gallbladder mucosa (epithelium and lamina propria) in ACC (n = 16) and CCC (n = 55) groups using modern spatial visualisation technique. Results: Quantitative analysis of IHC signals showed no significant differences in IL-1α and IL-6, and immunoexpression in patients with ACC and CCC. A significantly greater IHC expression of TNF-α was detected in CCC as compared with ACC group. In either of the patient groups immunoexpression of IL-1α and of TNF-α was significantly higher than that of IL-6. Immunoexpression of TNF-α was significantly higher than that of IL-1α only in CCC group. A positive correlation was disclosed between IHC expression of IL-1α and body mass index in CCC group. IHC expression of TNF-α correlated positively with expression of CD68 molecule (histiocytic marker), number of leukocytes in blood and higher grading of gallbladder wall in ACC group. Conclusions: A more pronounced IHC expression of TNF-α and IL-1α than IL-6 in both types of cholecystitis may suggest the role of these cytokines in pathogenesis of cholelithiasis. IHC expression of TNF- α shows better correlation with clinical/laboratory data in acute cholecystitis, and its quantitative prevalence over the remaining cytokines points to the role of the TNF-α in maintenance of inflammation in the course of cholelithiasis

Decreased Left Ventricular Torsion and Untwisting in Children with Dilated Cardiomyopathy

The purpose of this study was to analyze left ventricular (LV) torsion and untwisting, and to evaluate the correlation between torsion and other components of LV contraction in children with dilated cardiomyopathy (DCM). Segmental and global rotation, rotational rate (Vrot) were measured at three levels of LV using the two-dimensional (2D) speckle tracking imaging (STI) method in 10 DCM patients (range 0.6-15 yr, median 6.5 yr, 3 females) and 17 age- and sex-matched normal controls. Global torsion was decreased in DCM (peak global torsion; 10.9±4.6° vs. 0.3±2.1°, p<0.001). Loss of LV torsion occurred mainly by the diminution of counterclockwise apical rotation and was augmented by somewhat less reduction in clockwise basal rotation. In DCM, the normal counterclockwise apical rotation was not observed, and the apical rotation about the central axis was clockwise or slightly counterclockwise (peak apical rotation; 5.9±4.1° vs. -0.9±3.1°, p<0.001). Systolic counterclockwise Vrot and early diastolic clockwise Vrot at the apical level were decreased or abolished. In DCM, decreased systolic torsion and loss of early diastolic recoil contribute to LV systolic and diastolic dysfunction. The STI method may facilitate the serial evaluation of the LV torsional behavior in clinical settings and give new biomechanical concepts for better management of patients with DCM

Variation in the COVID-19 infection-fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis

Background The infection-fatality ratio (IFR) is a metric that quantifies the likelihood of an individual dying once infected with a pathogen. Understanding the determinants of IFR variation for COVID-19, the disease caused by the SARS-CoV-2 virus, has direct implications for mitigation efforts with respect to clinical practice, non-pharmaceutical interventions, and the prioritisation of risk groups for targeted vaccine delivery. The IFR is also a crucial parameter in COVID-19 dynamic transmission models, providing a way to convert a population's mortality rate into an estimate of infections.Methods We estimated age-specific and all-age IFR by matching seroprevalence surveys to total COVID-19 mortality rates in a population. The term total COVID-19 mortality refers to an estimate of the total number of deaths directly attributable to COVID-19. After applying exclusion criteria to 5131 seroprevalence surveys, the IFR analyses were informed by 2073 all-age surveys and 718 age-specific surveys (3012 age-specific observations). When seroprevalence was reported by age group, we split total COVID-19 mortality into corresponding age groups using a Bayesian hierarchical model to characterise the non-linear age pattern of reported deaths for a given location. To remove the impact of vaccines on the estimated IFR age pattern, we excluded age-specific observations of seroprevalence and deaths that occurred after vaccines were introduced in a location. We estimated age-specific IFR with a non-linear meta-regression and used the resulting age pattern to standardise all-age IFR observations to the global age distribution. All IFR observations were adjusted for baseline and waning antibody-test sensitivity. We then modelled age-standardised IFR as a function of time, geography, and an ensemble of 100 of the top-performing covariate sets. The covariates included seven clinical predictors (eg, age-standardised obesity prevalence) and two measures of health system performance. Final estimates for 190 countries and territories, as well as subnational locations in 11 countries and territories, were obtained by predicting age-standardised IFR conditional on covariates and reversing the age standardisation.Findings We report IFR estimates for April 15, 2020, to January 1, 2021, the period before the introduction of vaccines and widespread evolution of variants. We found substantial heterogeneity in the IFR by age, location, and time. Age-specific IFR estimates form a J shape, with the lowest IFR occurring at age 7 years (0-0023%, 95% uncertainty interval [UI] 0-0015-0-0039) and increasing exponentially through ages 30 years (0-0573%, 0-0418-0-0870), 60 years (1-0035%, 0-7002-1-5727), and 90 years (20-3292%, 14-6888-28-9754). The countries with the highest IFR on July 15, 2020, were Portugal (2-085%, 0-946-4-395), Monaco (1-778%, 1-265-2-915), Japan (1-750%, 1-302-2-690), Spain (1-710%, 0-991-2-718), and Greece (1-637%, 1-155-2-678). All-age IFR varied by a factor of more than 30 among 190 countries and territories.After age standardisation, the countries with the highest IFR on July 15, 2020, were Peru (0-911%, 0-636-1-538), Portugal (0-850%, 0-386-1-793), Oman (0-762%, 0-381-1-399), Spain (0-751%, 0-435-1-193), and Mexico (0-717%, 0-426-1-404). Subnational locations with high IFRs also included hotspots in the UK and southern and eastern states of the USA. Sub-Saharan African countries and Asian countries generally had the lowest all-age and age-standardised IFRs. Population age structure accounted for 74% of logit-scale variation in IFRs estimated for 39 in-sample countries on July 15, 2020. A post-hoc analysis showed that high rates of transmission in the care home population might account for higher IFRs in some locations. Among all countries and territories, we found that the median IFR decreased from 0-466% (interquartile range 0-223-0-840) to 0-314% (0-143-0-551) between April 15, 2020, and Jan 1, 2021.Interpretation Estimating the IFR for global populations helps to identify relative vulnerabilities to COVID-19. Information about how IFR varies by age, time, and location informs clinical practice and non-pharmaceutical interventions like physical distancing measures, and underpins vaccine risk stratification. IFR and mortality risk form a J shape with respect to age, which previous research, such as that by Glynn and Moss in 2020, has identified to be a common pattern among infectious diseases. Understanding the experience of a population with COVID-19 mortality requires consideration for local factors; IFRs varied by a factor of more than 30 among 190 countries and territories in this analysis. In particular, the presence of elevated age-standardised IFRs in countries with well resourced health-care systems indicates that factors beyond health-care capacity are important. Potential extenuating circumstances include outbreaks among care home residents, variable burdens of severe cases, and the population prevalence of comorbid conditions that increase the severity of COVID-19 disease. During the pre-vaccine period, the estimated 33% decrease in median IFR over 8 months suggests that treatment for COVID-19 has improved over time. Estimating IFR for the pre-vaccine era provides an important baseline for describing the progression of COVID-19 mortality patterns.Funding Bill &amp; Melinda Gates Foundation, J Stanton, T Gillespie, and J and E Nordstrom Copyright (c) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license

Modellumsetzungen von sekundaeren Aminen und Aminosaeuren mit cyclischen Enolonen als Beitrag zur Kenntnis der Maillard-Reaktion

SIGLETIB: DP 6787 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman