Hormonal changes throughout the menstrual cycle and increased anterior cruciate ligament laxity in females

Journal ArticleOBJECTIVE: To determine whether women experience significantly greater anterior cruciate ligament (ACL) laxity in conjunction with estrogen and progesterone surges during a normal 28- to 30-day menstrual cycle. DESIGN AND SETTING: Serial estrogen and progesterone levels were measured via radioimmunoassay procedures to identify the follicular and luteal phases of a subject's menstrual cycle and to determine periods of peak hormonal surges. Concomitant ACL laxity measures were taken using a knee arthrometer. Hormone levels and ACL laxity were assessed on days 1, 10, 11, 12, 13, 20, 21, 22, and 23 of the menstrual cycle. Day 1 corresponds to the menstrual phase, when estrogen and progesterone levels are at their lowest. Days 10 through 13 correspond to peak estrogen surge (follicular phase), and days 20 through 23 correspond to peak progesterone surge (luteal phase). SUBJECTS: Seven active females between the ages of 21 and 32 years with at least one apparently healthy knee (no known knee anomalies) volunteered for participation in this study. Each subject stated that she experienced a normal (28- to 30-day) menstrual cycle and was not currently taking any type of hormone therapy (eg, birth control medication). MEASUREMENTS: Blood was drawn on days 1, 10, 11, 12, 13, 20, 21, 22, and 23 of each subject's menstrual cycle, and ACL laxity measurements were assessed immediately after the blood draws. Estrogen and progesterone levels were determined via radioimmunoassay procedures, and ACL laxity was determined using a knee arthrometer. RESULTS: A within-subjects, repeated-measures analysis of variance was applied to determine the presence or absence of significant differences in ACL laxity values over the course of a subject's menstrual cycle. We found a significant difference in ACL laxity when comparing baseline levels of estrogen with peak levels of estrogen. A significant increase in ACL laxity was also noted when comparing baseline levels of progesterone with peak levels of progesterone. CONCLUSIONS: ACL laxity increased significantly throughout the menstrual cycle when comparing baseline with peak levels of estrogen and progesterone

Surgical peri-implantitis treatment with and without guided bone regeneration. A randomized controlled trial

Objective: To evaluate the efficacy of reconstructive peri-implantitis treatment. Materials and Methods: Forty participants, with peri-implantitis and a contained intraosseous defect, were randomized to access flap (control) or access flap with xenograft and collagen membrane (test). All received systemic antimicrobials. Blinded examiners recorded probing depths (PD), bleeding and suppuration on probing (BOP & SOP), soft tissue levels, and marginal bone levels (MBL) at baseline and 12 months. Patient reported outcomes were recorded. The primary outcome was PD change. Results: All 40 participants (40 implants) completed the 12-month study. The mean (standard deviation) PD reduction (deepest site) was 4.2 (1.8) mm in the control and 3.7 (1.9) mm in the test group. MBL gain (deepest site) was 1.7 (1.6) mm in the control and 2.4 (1.4) mm in the test group. Absence of BOP & SOP was observed at 60% of both control and test implants. Buccal recession was 0.9 (1.6) mm in the control and 0.4 (1.1) mm in the test group. A successful outcome (absence of PD ≥ 5 mm with BOP, absence of SOP and absence of progressive bone loss) was achieved for 90% of the control and 85% of test group implants. No statistically significant differences in clinical or radiographic parameters were found between treatment groups. 30% of participants experienced mild gastro-intestinal disturbances. Reporting followed CONSORT guidelines. Conclusion: Similar clinical and radiographic improvements at 12 months were observed with high levels of patient satisfaction for both the access flap and xenograft covered by collagen membrane groups. Registered clinical trials.gov. ID:NCT03163602 (23/05/2017)

Characterization of a biotrickling filter treating methanol vapours

[Abstract] The aim of this research is to characterize a biotrickling filter (BTF) treating methanol vapour emissions. The parameters studied were the nitrogen concentration in the nutrient solution and the empty bed residence time (EBRT). The effect of continuously recycling the nutrient solution was also analyzed. At nitrogen concentrations as low as 0.001 gN L-1, the BTF presented removal efficiencies higher than 70 % for an inlet load of 110 g m-3 h-1. A nitrogen concentration of 0.005 gN L-1 was used to study the effect of EBRT and the continuous recirculation of nutrient solution. At a constant methanol inlet concentration of 1500 ppmv, the BTF was operated in a range of EBRT from 20 to 265 s and the removal efficiencies respectively attained were 40 and 90 %. Methanol vapours were absorbed into the lixiviate and were taken into account in analysing the results

Multi-utility Learning: Structured-output Learning with Multiple Annotation-specific Loss Functions

Structured-output learning is a challenging problem; particularly so because of the difficulty in obtaining large datasets of fully labelled instances for training. In this paper we try to overcome this difficulty by presenting a multi-utility learning framework for structured prediction that can learn from training instances with different forms of supervision. We propose a unified technique for inferring the loss functions most suitable for quantifying the consistency of solutions with the given weak annotation. We demonstrate the effectiveness of our framework on the challenging semantic image segmentation problem for which a wide variety of annotations can be used. For instance, the popular training datasets for semantic segmentation are composed of images with hard-to-generate full pixel labellings, as well as images with easy-to-obtain weak annotations, such as bounding boxes around objects, or image-level labels that specify which object categories are present in an image. Experimental evaluation shows that the use of annotation-specific loss functions dramatically improves segmentation accuracy compared to the baseline system where only one type of weak annotation is used

Multiband theory of multi-exciton complexes in self-assembled quantum dots

We report on a multiband microscopic theory of many-exciton complexes in self-assembled quantum dots. The single particle states are obtained by three methods: single-band effective-mass approximation, the multiband $k\cdot p$ method, and the tight-binding method. The electronic structure calculations are coupled with strain calculations via Bir-Pikus Hamiltonian. The many-body wave functions of $N$ electrons and $N$ valence holes are expanded in the basis of Slater determinants. The Coulomb matrix elements are evaluated using statically screened interaction for the three different sets of single particle states and the correlated $N$-exciton states are obtained by the configuration interaction method. The theory is applied to the excitonic recombination spectrum in InAs/GaAs self-assembled quantum dots. The results of the single-band effective-mass approximation are successfully compared with those obtained by using the of $k\cdot p$ and tight-binding methods.Comment: 10 pages, 8 figure

Logistics sprawl in monocentric and polycentric metropolitan areas: the cases of Paris, France, and the Randstad, the Netherlands

The phenomenon of urban sprawl has been studied extensively. Most research so far has focused on residential settlements. A growing number of studies have addressed industrial deconcentration. Our focus in this paper is on logistics sprawl, i.e. the growth and suburban relocation of warehousing activities. Specifically, we investigate the difference in logistics sprawl between monocentric and polycentric systems of cities. The literature suggests that logistics activities, like residential settlements, will gradually move to suburbs as land prices increase in central areas. As research for logistics has mostly focused on monocentric systems, the question is whether this also applies to polycentric systems. We compare two cases, the Paris region in France, representative of a monocentric development, and the Dutch Randstad area as a polycentric case. We use regional statistics on warehouse settlements in both regions for a descriptive analysis of changes since the mid 2000s to derive metrics for concentration. The cases show different patterns of change in concentration. In contrast to Paris, logistics activities within the Randstad have intensified in dense areas. We explore the reasons that may explain this difference and conclude that urban structure, spatial planning policies and the freight hub quality of a region are factors of influence.

Comparing virtual patients with synthesized and natural speech

Virtual Patient (VP) simulations are often designed to use pre-recorded speech in order to provide more realism and immersion. However, using actors for recording these utterances has certain downsides. It can add to the cost during implementation, can take considerable time especially when a large number of VPs have to be created, and is not very flexible for example when sentences or words have to be added frequently. This study aims to explore the use of synthesized speech as an alternative to pre-recorded speech for VPs. Two medical scenarios have been prepared for this study, and both have been implemented using a VP with natural language or with synthesized speech. In a pilot study we explored students' retention rates of the symptoms reported by the VP under both conditions to investigate whether synthesized speech can serve as a good enough alternative

Making the Desert Bloom: Landscape Photography and Identity in the Owens Valley American West

This thesis analyzes the way in which landscape photography has historically been used as a colonialist tool to perpetuate narratives of control over the American West during the mid to late 1800s. I use this framework to interrogate how these visual narratives enforced ideas about American identity and whiteness relative to power over the landscape, indigenous people and the Japanese-Americans imprisoned at Manzanar within Owens Valley, California. I argue that because photographic representation is controlled by colonist powers, images of people within the American West reinforce imperialist rhetoric that positions whiteness in control of the land; thus, white settlers used this narrative to justify their stagnating agricultural development in the Owens Valley, Native Americans were documented as a part of the landscape to be controlled, and the internees at Manzanar were portrayed such that Japanese culture was obscured in favor of assimilationist, Americanizing tropes of their status as new pioneers on the American Frontier