60 research outputs found
Self-sealing propellant-actuated device eliminates atmosphere contamination
Device retains internally generated combustion products by a plug which seals the barrel end after projectile ejection. Since no blast wave is produced, only the projectile can disturb the surrounding surfaces and atmosphere
Intra- site 4f-5d electronic correlations in the quadrupolar model of the gamma-alpha phase transition in Ce
As a possible mechanism of the phase transition in pristine
cerium a change of the electronic density from a disordered state with symmetry
Fm-3m to an ordered state Pa-3 has been proposed. Here we include on-site and
inter- site electron correlations involving one localized 4f-electron and one
conduction 5d-electron per atom. The model is used to calculate the crystal
field of -Ce and the temperature evolution of the mean-field of
-Ce. The formalism can be applied to crystals where quadrupolar
ordering involves several electrons on the same site.Comment: 12 pages, 2 figures, 4 tables, submitted to Phys. Rev.
Dendritic excitation–inhibition balance shapes cerebellar output during motor behaviour
Feedforward excitatory and inhibitory circuits regulate cerebellar output, but how these circuits interact to shape the somatodendritic excitability of Purkinje cells during motor behaviour remains unresolved. Here we perform dendritic and somatic patch-clamp recordings in vivo combined with optogenetic silencing of interneurons to investigate how dendritic excitation and inhibition generates bidirectional (that is, increased or decreased) Purkinje cell output during self-paced locomotion. We find that granule cells generate a sustained depolarization of Purkinje cell dendrites during movement, which is counterbalanced by variable levels of feedforward inhibition from local interneurons. Subtle differences in the dendritic excitation–inhibition balance generate robust, bidirectional changes in simple spike (SSp) output. Disrupting this balance by selectively silencing molecular layer interneurons results in unidirectional firing rate changes, increased SSp regularity and disrupted locomotor behaviour. Our findings provide a mechanistic understanding of how feedforward excitatory and inhibitory circuits shape Purkinje cell output during motor behaviour
Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex
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