Increased adrenal secretion of norepinephrine and epinephrine after endotoxin and its reversal with corticosteroids

Two groups of dogs were subjected to an LD60 of E. coli endotoxin. Group II animals were pretreated with 30 mg/kg of methyl prednisolone sodium succinate before the intravenous endotoxin. All animals had hypotension and diminished cardiac index after endotoxin administration.The nonsteroid dogs, Group I, demonstrated increased adrenal secretion of norepinephrine and epinephrine. Arterial plasma catecholamines were comparable. Group II steroid-treated animals demonstrated lower adrenal secretion of norepinephrine and epinephrine when compared to Group I, nonsteroid animals. These results demonstrate that pretreatment with pharmacologic doses of synthetic corticosteroids exerts a specific effect on the adrenal medulla in endotoxin shock that profoundly limits adrenal catecholamine release.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22090/1/0000514.pd

Self-perception of the benefits of myofascial mobilization in physical exercise practitioners: a cross-sectional study

Myofascial mobilization has been frequently used in sports as a way to improve fascia restrictions that arise with physical activities. Objective: To analyze and compare the benefits of myofascial mobilization for adult practitioners of regular physical exercise, verifying the methods and techniques used, thus comparing the greater effectiveness according to the practitioners' perception. Methods: This is a cross-sectional study where an online questionnaire was applied to 160 people of both sexes, with the aim of analyzing information on applied techniques and their effectiveness. Data were analyzed using descriptive statistics. Results: The results showed that satisfaction and benefits were predominant, and the use of the manual technique was the most preferred among practitioners, emphasizing that most were applied by physiotherapists. Conclusion: Those who use the technique, regardless of the way it is performed, the results are considered satisfactory and bring well-being and benefits to the health of practitioners of physical exercise.A mobilização miofascial vem sendo utilizada com frequência no meio esportivo como forma de melhorar as restrições da fáscia que surgem com as atividades físicas.  Objetivo: Analisar e comparar os benefícios da mobilização miofascial para praticantes adultos de exercício físico regular, verificando os métodos e técnicas utilizados, assim comparando a maior eficácia segundo a percepção dos praticantes. Métodos: Trata-se de um estudo transversal onde foi aplicado um questionário online a 160 pessoas de ambos os sexos, com o intuito de analisar informações de técnicas aplicadas e sua eficácia. Os dados foram analisados por meio da estatística descritiva. Resultados: Os resultados demonstraram que a satisfação e benefícios foram predominantes, e o uso da técnica manual foi a de maior escolha entre os praticantes, ressaltando que a maioria foi aplicada por fisioterapeutas. Conclusões: Quem utiliza a técnica, independente da forma executada, os resultados são considerados satisfatórios e trazem bem-estar e benefícios à saúde dos praticantes de exercício físico