232 research outputs found

    Quiescent NIR and optical counterparts to candidate black hole X-ray binaries

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    We present near-infrared and optical imaging of fifteen candidate black hole X-ray binaries. In addition to quiescent observations for all sources, we also observed two of these sources (IGR J17451-3022 and XTE J1818-245) in outburst. We detect the quiescent counterpart for twelve out of fifteen sources, and for the remaining three we report limiting magnitudes. The magnitudes of the detected counterparts range between KsK_s = 17.59 and KsK_s = 22.29 mag. We provide (limits on) the absolute magnitudes and finding charts of all sources. Of these twelve detections in quiescence, seven represent the first quiescent reported values (for MAXI J1543-564, XTE J1726-476, IGR J17451-3022, XTE J1818-245, MAXI J1828-249, MAXI J1836-194, Swift J1910.2-0546) and two detections show fainter counterparts to XTE J1752-223 and XTE J2012+381 than previously reported. We used theoretical arguments and observed trends, for instance between the outburst and quiescent X-ray luminosity and orbital period PorbP_{orb} to derive an expected trend between ΔKs\Delta K_s and PorbP_{orb} of ΔKslogPorb0.565\Delta K_s \propto \log P_{orb}^{0.565}. Comparing this to observations we find a different behaviour. We discuss possible explanations for this result.Comment: 18 pages, 6 figures. Accepted for publication in MNRA

    Evaluation of Life History Diversity, Habitat Connectivity, and Survival Benefits Associated with Habitat Restoration Actions in the Lower Columbia River and Estuary, Annual Report 2009

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    This report describes the 2009 research conducted under the U.S. Army Corps of Engineers (USACE or Corps) project EST-09-P-01, titled “Evaluation of Life History Diversity, Habitat Connectivity, and Survival Benefits Associated with Habitat Restoration Actions in the Lower Columbia River and Estuary.” The research was conducted by the Pacific Northwest National Laboratory, Marine Science Laboratory and Hydrology Group, in partnership with the University of Washington, School of Aquatic and Fishery Sciences, Columbia Basin Research, and Earl Dawley (NOAA Fisheries, retired). This Columbia River Fish Mitigation Program project, referred to as “Salmonid Benefits,” was started in FY 2009 to evaluate the state-of-the science regarding the ability to quantify the benefits to listed salmonids1 of habitat restoration actions in the lower Columbia River and estuary

    Clinical Utility of Fecal Calprotectin Monitoring in Asymptomatic Patients with Inflammatory Bowel Disease:A Systematic Review and Practical Guide

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    Background: In asymptomatic patients with inflammatory bowel disease (IBD), "monitoring" involves repeated testing aimed at early recognition of disease exacerbation. We aimed to determine the usefulness of repeated fecal calprotectin (FC) measurements to predict IBD relapses by a systematic literature review. Methods: An electronic search was performed in Medline, Embase, and Cochrane from inception to April 2016. Inclusion criteria were prospective studies that followed patients with IBD in remission at baseline and had at least 2 consecutive FC measurements with a test interval of 2 weeks to 6 months. Methodological assessment was based on the second Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) checklist. Results: A total of 1719 articles were identified; 193 were retrieved for full text review. Six studies met eligibility for inclusion. The time interval between FC tests varied between 1 and 3 months. Asymptomatic patients with IBD who had repeated FC measurements above the study's cutoff level had a 53% to 83% probability of developing disease relapse within the next 2 to 3 months. Patients with repeated normal FC values had a 67% to 94% probability to remain in remission in the next 2 to 3 months. The ideal FC cutoff for monitoring could not be identified because of the limited number studies meeting inclusion criteria and heterogeneity between selected studies. Conclusions: Two consecutively elevated FC values are highly associated with disease relapse, indicating a consideration to proactively optimize IBD therapy plans. More prospective data are necessary to assess whether FC monitoring improves health outcomes

    Феномен мастурбации: негативное или позитивное явление?

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    Рассмотрены разные взгляды на роль мастурбации в становлении сексуальности человека. Представлены результаты собственных исследований автора, проведенных с целью установить значение этого феномена для формирования сексуального поведения и сексуального здоровья.Various opinions about the role of masturbation in human sexuality development are discussed. The findings of the original research performed to evaluate the significance of this phenomenon in formation of sexual behavior and sexual health are reported

    Breaking the limit: Super-Eddington accretion onto black holes and neutron stars

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    With the recent discoveries of massive and highly luminous quasars at high redshifts (z∼7; e.g. Mortlock et al. 2011), the question of how black holes (BHs) grow in the early Universe has been cast in a new light. In order to grow BHs with M_(BH) > 10^9 M⊙ by less than a billion years after the Big Bang, mass accretion onto the low-mass seed BHs needs to have been very rapid (Volonteri & Rees, 2005). Indeed, for any stellar remnant seed, the rate required would need to exceed the Eddington limit. This is the point at which the outward force produced by radiation pressure is equal to the gravitational attraction experienced by the in-falling matter. In principle, this implies that there is a maximum luminosity an object of mass M can emit; assuming spherical accretion and that the opacity is dominated by Thompson scattering, this Eddington luminosity is L_E = 1.38×10^(38)(M/M⊙) erg s^(−1). In reality, it is known that this limit can be violated, due to non-spherical geometry or various kinds of instabilities. Nevertheless, the Eddington limit remains an important reference point, and many of the details of how accretion proceeds above this limit remain unclear. Understanding how this so-called super-Eddington accretion occurs is of clear cosmological importance, since it potentially governs the growth of the first supermassive black holes (SMBHs) and the impact this growth would have had on their host galaxies (‘feedback') and the epoch of reionization, as well as improving our understanding of accretion physics more generally

    Applications of the PowerGlove

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    The hand is important in many daily life activities. During aging, quality of fine motor control of hand and fingers is decreasing. Also motor symptoms of the hand are important to define for instance the neurological state of a Parkinson’s disease patient. Although objective and reliable measurement of hand and finger dynamics is of interest, current measurement systems are limited. This paper describes the application of the PowerGlove, a new measurement system based on miniature inertial and magnetic sensors, to study the finger interdependency in healthy elderly and objectively quantify hand motor symptoms in Parkinson’s disease. Results of pilot experiments in young healthy subjects are shown to evaluate the feasibility of the applications

    Characterization of pre-existing arrhythmogenic substrate associated with de novo early and late postoperative atrial fibrillation

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    Background: PoAF is the most common complication after cardiac surgery and may occur in patients with pre-existing arrhythmogenic substrate. Characterization of this substrate could aid in identifying patients at risk for PoAF. We therefore compared intra-atrial conduction parameters and electrogram morphology between patients without and with early- (≤5 days after surgery) and late- (up to 5 years) postoperative atrial fibrillation (PoAF). Methods and results: Epicardial mapping of the right and left atrium and Bachmann's Bundle (BB) was performed during sinus rhythm (SR) in 263 patients (207male, 67 ± 11 years). Unipolar potentials were classified as single, short or long double and fractionated potentials. Unipolar voltage, fractionation delay (time difference between the first and last deflection), conduction velocity (CV) and conduction block (CB) prevalence were measured. Comparing patients without (N = 166) and with PoAF (N = 97), PoAF was associated with lower CV and more CB at BB. Unipolar voltages were lower and more low-voltage areas were found at the left and right atrium and BB in PoAF patients. These differences were more pronounced in patients with late-PoAF (6%), which could even occur up to 5 years after surgery. Although several electrophysiological parameters were related to PoAF, age was the only independent predictor. Conclusions: Patients with de novo PoAF have more extensive arrhythmogenic substrate prior to cardiac surgery compared to those who remained in SR, which is even more pronounced in late-PoAF patients. Future studies should evaluate whether intra-operative electrophysiological examination enables identification of patients at risk for developing PoAF and hence (preventive) therapy.</p

    Ballistic Josephson junctions in edge-contacted graphene

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    Hybrid graphene-superconductor devices have attracted much attention since the early days of graphene research. So far, these studies have been limited to the case of diffusive transport through graphene with poorly defined and modest quality graphene-superconductor interfaces, usually combined with small critical magnetic fields of the superconducting electrodes. Here we report graphene based Josephson junctions with one-dimensional edge contacts of Molybdenum Rhenium. The contacts exhibit a well defined, transparent interface to the graphene, have a critical magnetic field of 8 Tesla at 4 Kelvin and the graphene has a high quality due to its encapsulation in hexagonal boron nitride. This allows us to study and exploit graphene Josephson junctions in a new regime, characterized by ballistic transport. We find that the critical current oscillates with the carrier density due to phase coherent interference of the electrons and holes that carry the supercurrent caused by the formation of a Fabry-P\'{e}rot cavity. Furthermore, relatively large supercurrents are observed over unprecedented long distances of up to 1.5 μ\mum. Finally, in the quantum Hall regime we observe broken symmetry states while the contacts remain superconducting. These achievements open up new avenues to exploit the Dirac nature of graphene in interaction with the superconducting state.Comment: Updated version after peer review. Includes supplementary material and ancillary file with source code for tight binding simulation

    Long-term cardiometabolic disease risk in women with PCOS:a systematic review and meta-analysis

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    BACKGROUND: Polycystic ovary syndrome (PCOS) is associated with cardiometabolic disease, but recent systematic reviews and meta-analyses of longitudinal studies that quantify these associations are lacking. OBJECTIVE AND RATIONALE: Is PCOS a risk factor for cardiometabolic disease? SEARCH METHODS: We searched from inception to September 2019 in MEDLINE and EMBASE using controlled terms (e.g. MESH) and text words for PCOS and cardiometabolic outcomes, including cardiovascular disease (CVD), stroke, myocardial infarction, hypertension (HT), type 2 diabetes (T2D), metabolic syndrome and dyslipidaemia. Cohort studies and case-control studies comparing the prevalence of T2D, HT, fatal or non-fatal CVD and/or lipid concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TGs) between women with and without PCOS of ≥18 years of age were eligible for this systematic review and meta-analysis. Studies were eligible regardless of the degree to which they adjusted for confounders including obesity. Articles had to be written in English, German or Dutch. Intervention studies, animal studies, conference abstracts, studies with a follow-up duration less than 3 years and studies with less than 10 PCOS cases were excluded. Study selection, quality assessment (Newcastle-Ottawa Scale) and data extraction were performed by two independent researchers. OUTCOMES: Of the 5971 identified records, 23 cohort studies were included in the current systematic review. Women with PCOS had increased risks of HT (risk ratio (RR): 1.75, 95% CI 1.42 to 2.15), T2D (RR: 3.00, 95% CI 2.56 to 3.51), a higher serum concentration of TC (mean difference (MD): 7.14 95% CI 1.58 to 12.70 mg/dl), a lower serum concentration of HDL-C (MD: -2.45 95% CI -4.51 to -0.38 mg/dl) and increased risks of non-fatal cerebrovascular disease events (RR: 1.41, 95% CI 1.02 to 1.94) compared to women without PCOS. No differences were found for LDL-C (MD: 3.32 95% CI -4.11 to 10.75 mg/dl), TG (MD 18.53 95% CI -0.58 to 37.64 mg/dl) or coronary disease events (RR: 1.78, 95% CI 0.99 to 3.23). No meta-analyses could be performed for fatal CVD events due to the paucity of mortality data. WIDER IMPLICATIONS: Women with PCOS are at increased risk of cardiometabolic disease. This review quantifies this risk, which is important for clinicians to inform patients and to take into account in the cardiovascular risk assessment of women with PCOS. Future clinical trials are needed to assess the ability of cardiometabolic screening and management in women with PCOS to reduce future CVD morbidity
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