19 research outputs found
Migration and identity processes among first-generation British South Asians
There has been little scholarly attention to the identities and migratory experiences of first-generation British South Asians, especially from social psychologists. Drawing upon Identity Process Theory, this article examines the inter-relations between migration and identity processes among twenty first-generation British South Asians. The interview data were analysed using qualitative thematic analysis. Results suggested that migration was perceived as a means of enhancing identity and that following migration individuals acquired a âhigherâ social status in the homeland. Moreover, the psychologically traumatic aspects of migration, such as the loss of community and âotherisationâ from one's ethnic ingroup, were outlined. It is argued that migration can have profound socio-psychological implications and that decades later it can continue to shape individuals' sense of self and their attachment to relevant social categories. Furthermore, migration has important outcomes for the extent and nature of British national identification as well one's relationship with the ethnic âhomelandâ
Hip hop desis : South Asian Americans, Blackness, and a Global Race Consciousness : [book review]
Non UBCUnreviewedOthe
Components of male gametophytic competition in Vigna unguiculata Walp
This article does not have an abstract
Development and Validation of Rapid Stability-Indicating RP-HPLC Method for Assay and Related Substances of Solifenacin Succinate
Methyl-Thiazoles: A Novel Mode of Inhibition with the Potential to Develop Novel Inhibitors Targeting InhA in Mycobacterium tuberculosis
InhA
is a well validated Mycobacterium tuberculosis (Mtb) target as evidenced by the clinical success of isoniazid.
Translating enzyme inhibition to bacterial cidality by targeting the
fatty acid substrate site of InhA remains a daunting challenge. The
recent disclosure of a methyl-thiazole series demonstrates that bacterial
cidality can be achieved with potent enzyme inhibition and appropriate
physicochemical properties. In this study, we report the molecular
mode of action of a lead methyl-thiazole, along with analogues with
improved CYP inhibition profile. We have identified a novel mechanism
of InhA inhibition characterized by a hitherto unreported âY158-outâ
inhibitor-bound conformation of the protein that accommodates a neutrally
charged âwarheadâ. An additional novel hydrophilic interaction
with protein residue M98 allows the incorporation of favorable physicochemical
properties for cellular activity. Notably, the methyl-thiazole prefers
the NADH-bound form of the enzyme with a <i>K</i><sub>d</sub> of âŒ13.7 nM, as against the NAD<sup>+</sup>-bound form of
the enzyme