The limits to prime ministerial autonomy: Cameron and the constraints of coalition

In heading up a coalition David Cameron has had to confront two unusual constraints that prevent him from being a dominant prime minister. The first constraint, something unfamiliar to previous prime ministers, is his having to work with and through a coalition partner firmly placed to the Conservatives’ left. The second constraint, equally problematic but more familiar, is that Cameron has faced a restive Conservative parliamentary party in which a sizable minority of Tory MPs remained unreconciled to his political agenda. These two interrelated constraints mean Cameron has lacked the freedom of manoeuvre enjoyed by most past prime ministers. Two aspects of Cameron’s premiership help cast light on his predicament: first, his relations with Nick Clegg and the Liberal Democrats and second, the nature of his dependency upon Conservative MPs. We look at these in turn and conclude by assessing Cameron’s effectiveness as prime minister

Discovery and Assessment of New Target Sites for Anti-HIV Therapies

Human immunodeficiency virus (HIV) infects cells by endocytosis and takes over parts of the cell’s reaction pathways in order to reproduce itself and spread the infection. One such pathway taken over by HIV becomes the inflammatory pathway which uses Nuclear Factor κB (NF-κB) as the principal transcription factor. Therefore, knocking out the NF-κB pathway would prevent HIV from reproducing itself. In this report, our goal is to produce a simple model for this pathway with which we can identify potential targets for anti-HIV therapies and test out various hypotheses. We present a very simple model with four coupled first-order ODEs and see what happens if we treat IκK concentration as a parameter that can be controlled (by some unspecified means). In Section 3, we augment this model to account for activation and deactivation of IκK, which is controlled (again, by some unspecified means) by TNF

Transient Resonant Spiking in Degenerate Four Wave Mixing in Saturable Absorbers

We show that under certain conditions the time evolution of the conjugate reflectivity for degenerate four wave mixing in saturable absorbers can exhibit a resonant spike after a time equal to the molecular relaxation time of the system

Comprehensive Cookery

Written by Lola M. Heffernan, Vice Principal, Marymount Comprehensive School, Sallynoggin to provide a comprehensive course covering the cookery section of the Home Economics syllabus prescribed for the Junior and Senior cycles of post-primary schools. Published by Longman Browne & Nolan at the Richview Press, Dublin in 1970. 224p., 24cm., paperbackhttps://arrow.tudublin.ie/irckbooks/1031/thumbnail.jp

Hub and blade structural loads measurements of an SA349/2 helicopter

Data from 23 flight conditions, including level flights ranging from advance ratio mu = 0.14 to 0.37 and steady turning flights from advance ratio mu = 0.26 to 0.35, are presented for an Aerospatiale SA349/2 Gazelle helicopter. The data include hub loads data (for 6 of the 23 conditions), blade structural data at eleven different blade radial stations, and fuselage structural data. All dynamic data are presented as harmonic analysis coefficients (ten harmonics per rotor revolution). The data acquisition and reduction procedures are also documented. Blade structural and inertial properties are provided in addition to control system geometry and properties

Decision making methodology : test of logic and first field test.

EducationDoctor of Education (Ed.D.

Hub loads analysis of the SA349/2 helicopter

The forces and moments at the rotor hub of an Aerospatiale SA349/2 helicopter were investigated. The study included three main topics. First, measured hub forces and moments for a range of level flight conditions (mu = 0.14 to 0.37) were compared with predictions from a comprehensive rotorcraft analysis to examine the influence of the wake model on the correlations. Second, the effect of changing the blade mass distribution and blade chordwise center of gravity location on the 3/rev nonrotating frame hub loads was studied for a high-speed flight condition (mu = 0.37). Third, the use of higher harmonic control to reduce nonrotating frame 3/rev hub shear forces was investigated. The last two topics were theoretical studies only

Globalising cartography?:the International Map of the World, the International Geographical Union, and the United Nations

Few maps mirror the history of the twentieth century as closely as the International Map of the World (IMW). A proposal for a map of the entire globe on a scale of 1:1 million, using standard conventional signs, was presented at the Fifth International Geographical Congress in Berne in 1891 by the German geographer Albrecht Penck. More than two decades later, the final specification was finally published shortly before the outbreak of the First World War, a crisis that brought a halt to the international collaboration on which the project depended. The IMW’s fortunes waxed and waned over the next three decades, necessitating a major review of its continuing value after the Second World War. A new IMW Executive Commission under the chairmanship of John Kirtland Wright, Director of the American Geographical Society, was established at the 1949 Lisbon conference of the International Geographical Union. Drawing on Wright’s correspondence in the AGS archives, this paper examines the debates between the national cartographic agencies and related societies involved in the future of the IMW, with particular reference to the transfer of the project’s Central Bureau from the British Ordnance Survey in Southampton to the United Nations in New York in the early 1950s. This discussion, which focused mainly on the need to combine the IMW with an internationalized version of the US-dominated 1:1 million World Aeronautical Chart, reveals the on-going tensions between the ideals of scientific internationalism embodied in the IMW’s original proposal and the harsh realities of national self-interest in the early years of the Cold War

Impact and Cost-Effectiveness of Point-Of-Care CD4 Testing on the HIV Epidemic in South Africa.

Rapid diagnostic tools have been shown to improve linkage of patients to care. In the context of infectious diseases, assessing the impact and cost-effectiveness of such tools at the population level, accounting for both direct and indirect effects, is key to informing adoption of these tools. Point-of-care (POC) CD4 testing has been shown to be highly effective in increasing the proportion of HIV positive patients who initiate ART. We assess the impact and cost-effectiveness of introducing POC CD4 testing at the population level in South Africa in a range of care contexts, using a dynamic compartmental model of HIV transmission, calibrated to the South African HIV epidemic. We performed a meta-analysis to quantify the differences between POC and laboratory CD4 testing on the proportion linking to care following CD4 testing. Cumulative infections averted and incremental cost-effectiveness ratios (ICERs) were estimated over one and three years. We estimated that POC CD4 testing introduced in the current South African care context can prevent 1.7% (95% CI: 0.4% - 4.3%) of new HIV infections over 1 year. In that context, POC CD4 testing was cost-effective 99.8% of the time after 1 year with a median estimated ICER of US$4,468/DALY averted. In healthcare contexts with expanded HIV testing and improved retention in care, POC CD4 testing only became cost-effective after 3 years. The results were similar when, in addition, ART was offered irrespective of CD4 count, and CD4 testing was used for clinical assessment. Our findings suggest that even if ART is expanded to all HIV positive individuals and HIV testing efforts are increased in the near future, POC CD4 testing is a cost-effective tool, even within a short time horizon. Our study also illustrates the importance of evaluating the potential impact of such diagnostic technologies at the population level, so that indirect benefits and costs can be incorporated into estimations of cost-effectiveness