The Macrame 1024 node switching network

The work reported involves the construction of a large modular testbed using IEEE 1355 DS link technology. A thousand nodes will be interconnected by a switching fabric based on the STC104 packet switch. The system has been designed and constructed in a modular way in order to allow a variety of different network topologies to be investigated. Network throughput and latency have been studied for different network topologies under various traffic conditions

Recent experiments on a small-angle/wide-angle X-ray scattering beam line at the ESRF

Recent results using a new combined small-angle/wide-angle X-ray scattering (SAXS/WAXS) beam line at the European Synchrotron Radiation Source (ESRF) will be presented. This beam line is specifically designed to be able to handle complicated sample environments required to perform time-resolved experiments mimicking processing conditions used in material science. Besides the attention that has been given to the interfacing of these sample environments to the beam line data acquisition system also the developments in detector technology will be discussed. The influence that a high count rate and low noise WAXS detector can have on the accuracy of experimental results in polymer crystallisation will be shown. It is shown that it is feasible to detect crystalline volume fractions as low as 10-3-10-4 in polymeric systems

The formation of a nanohybrid shish-kebab (NHSK) structure in melt-processed composites of poly (ethylene terephthalate) (PET) and multi-walled carbon nanotubes (MWCNTs)

The combination of synchrotron Small- and Wide-Angle X-ray scattering (SAXS/WAXS), and thermal analysis was used to follow the evolution of crystalline morphology and crystallization kinetics in a series of melt-processed composites of poly(ethylene terephthalate) (PET) and multiwall carbon nanotubes (MWCNT). The as-extruded PET-MWCNT composites underwent both hot and cold isothermal crystallizations where a final oriented nanohybrid shish-kebab (NHSK) crystalline structure was observed. An oriented NHSK structure was seen to persist even after melting and recrystallization of the composites. From the scattering data, we propose a model whereby the oriented MWCNTs act as heterogeneous nucleation surfaces (shish) and the polymer chains wrap around them and the crystallites (kebabs) grow epitaxially outwards during crystallization. However, depending on crystallization temperature, unoriented crystallites also grow in the polymer matrix, resulting in a combination of a NHSK and lamellar morphology. In contrast, the neat PET homopolymer showed the sporadic nucleation of a classic unoriented lamellar structure under the same isothermal crystallization conditions. These results provide a valuable insight into the distinctive modification of the crystalline morphology of melt-processed polymer-MWCNT composites prior to any secondary processing, having a significant impact on the use of MWCNTs as fillers in the processing and modification of the physical and mechanical properties of engineering polymers

In-situ uniaxial drawing of poly-L-lactic acid (PLLA): Following the crystalline morphology development using time-resolved SAXS/WAXS

Simultaneous synchrotron small- and wide-angle X-ray scattering (SAXS/WAXS) was used to follow the crystalline morphology evolution of poly-L- lactic acid (PLLA) during uniaxial deformation at various draw temperatures (Td). The mechanical behaviour of PLLA, was found to be strongly dependent on Td. 2D SAXS/WAXS data taken during the draw showed that at low Tds cavitation and voiding occurred and the initial crystallites underwent ‘overdrawing’ where they slip and are partially destroyed. SEM confirmed that surface voiding and cavitation had occurred at Td = 60 and 65 °C but was absent at higher Tds. During the draw, no long-range macromolecular lamellar structure was seen in the SAXS, but small crystallites of the disordered α′ crystal form of PLLA were observed in the WAXS at all Tds. The PLLA samples were then step annealed in a second processing stage (post-draw) to develop the oriented crystalline lamellar structure and increase the amount of the stable α crystalline form. SAXS/WAXS data showed that a highly oriented lamellar stack macrostructure developed on annealing, with increased crystallite size and crystallinity at all Tds. Furthermore, step annealing drove the crystalline transition in all samples from the disordered α′ crystal form to the stable α crystal form. Therefore, varying pre- and post-processing parameters can significantly influence the mechanical properties, orientation, crystalline morphology and crystal phase transition of the final PLLA material

Clinical and genetic characterization of individuals with predicted deleterious PHIP variants

Heterozygous deleterious variants in PHIP have been associated with behavioral problems, intellectual disability/developmental delay, obesity/overweight, and dysmorphic features (BIDOD syndrome). We report an additional 10 individuals with pleckstrin homology domain-interacting protein (PHIP)-predicted deleterious variants (four frameshift, three missense, two nonsense, and one splice site; six of which are confirmed de novo). The mutation spectrum is diverse, and there is no clustering of mutations across the protein. The clinical phenotype of these individuals is consistent with previous reports and includes behavioral problems, intellectual disability, developmental delay, hypotonia, and dysmorphic features. The additional individuals we report have a lower frequency of obesity than previous reports and a higher frequency of gastrointestinal problems, social deficits, and behavioral challenges. Characterizing additional individuals with diverse mutations longitudinally will provide better natural history data to assist with medical management and educational and behavioral support

A Computational Model of Visual Anisotropy

Visual anisotropy has been demonstrated in multiple tasks where performance differs between vertical, horizontal, and oblique orientations of the stimuli. We explain some principles of visual anisotropy by anisotropic smoothing, which is based on a variation on Koenderink's approach in [1]. We tested the theory by presenting Gaussian elongated luminance profiles and measuring the perceived orientations by means of an adjustment task. Our framework is based on the smoothing of the image with elliptical Gaussian kernels and it correctly predicted an illusory orientation bias towards the vertical axis. We discuss the scope of the theory in the context of other anisotropies in perception

An integrated general practice and pharmacy-based intervention to promote the use of appropriate preventive medications among individuals at high cardiovascular disease risk: protocol for a cluster randomized controlled trial

Background: Cardiovascular diseases (CVD) are responsible for significant morbidity, premature mortality, and economic burden. Despite established evidence that supports the use of preventive medications among patients at high CVD risk, treatment gaps remain. Building on prior evidence and a theoretical framework, a complex intervention has been designed to address these gaps among high-risk, under-treated patients in the Australian primary care setting. This intervention comprises a general practice quality improvement tool incorporating clinical decision support and audit/feedback capabilities; availability of a range of CVD polypills (fixed-dose combinations of two blood pressure lowering agents, a statin ± aspirin) for prescription when appropriate; and access to a pharmacy-based program to support long-term medication adherence and lifestyle modification. Methods: Following a systematic development process, the intervention will be evaluated in a pragmatic cluster randomized controlled trial including 70 general practices for a median period of 18 months. The 35 general practices in the intervention group will work with a nominated partner pharmacy, whereas those in the control group will provide usual care without access to the intervention tools. The primary outcome is the proportion of patients at high CVD risk who were inadequately treated at baseline who achieve target blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) levels at the study end. The outcomes will be analyzed using data from electronic medical records, utilizing a validated extraction tool. Detailed process and economic evaluations will also be performed. Discussion: The study intends to establish evidence about an intervention that combines technological innovation with team collaboration between patients, pharmacists, and general practitioners (GPs) for CVD prevention. Trial registration: Australian New Zealand Clinical Trials Registry ACTRN1261600023342

Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights.

OBJECTIVE: Dietary proteins are sensed by hypothalamic neurons and strongly influence multiple aspects of metabolic health, including appetite, weight gain, and adiposity. However, little is known about the mechanisms by which hypothalamic neural circuits controlling behavior and metabolism sense protein availability. The aim of this study is to characterize how neurons from the mediobasal hypothalamus respond to a signal of protein availability: the amino acid l-leucine. METHODS: We used primary cultures of post-weaning murine mediobasal hypothalamic neurons, hypothalamic neurons derived from human induced pluripotent stem cells, and calcium imaging to characterize rapid neuronal responses to physiological changes in extracellular l-Leucine concentration. RESULTS: A neurochemically diverse subset of both mouse and human hypothalamic neurons responded rapidly to l-leucine. Consistent with l-leucine's anorexigenic role, we found that 25% of mouse MBH POMC neurons were activated by l-leucine. 10% of MBH NPY neurons were inhibited by l-leucine, and leucine rapidly reduced AGRP secretion, providing a mechanism for the rapid leucine-induced inhibition of foraging behavior in rodents. Surprisingly, none of the candidate mechanisms previously implicated in hypothalamic leucine sensing (KATP channels, mTORC1 signaling, amino-acid decarboxylation) were involved in the acute activity changes produced by l-leucine. Instead, our data indicate that leucine-induced neuronal activation involves a plasma membrane Ca2+ channel, whereas leucine-induced neuronal inhibition is mediated by inhibition of a store-operated Ca2+ current. CONCLUSIONS: A subset of neurons in the mediobasal hypothalamus rapidly respond to physiological changes in extracellular leucine concentration. Leucine can produce both increases and decreases in neuronal Ca2+ concentrations in a neurochemically-diverse group of neurons, including some POMC and NPY/AGRP neurons. Our data reveal that leucine can signal through novel mechanisms to rapidly affect neuronal activity

Impact of the blending of kaolin on particulate matter (PM) emissions in a biomass field-scale 250 kW grate boiler

The aim of the study was to investigate the impact of adding kaolin on the partitioning of chemical elements in the particulate matter (PM) when virgin and waste woody biomass fuels were fired in a 250 kW grate boiler. A comprehensive analysis of the chemical compositions of the PM has been conducted, including alkali and non-volatile species, size-fractionated mass concentrations and micromorphology images. The results showed that the PM emission levels were significantly decreased by approximately 70–76 % and 60–66 % after the addition of kaolin to virgin wood (VW) and grade A recycled wood (RW), respectively, which inhibited the partitioning of the alkali species into fine and ultrafine PM. On the other hand, the concentration of the non-volatile elements, SiO2 and Al2O3, significantly increased in the PM emissions after the addition of kaolin due to the adhesion and aggregation of particulates between airborne kaolin and the fine and ultrafine PM. Moreover, the addition of the kaolin at 1.55 wt% showed comparable effects with that at 2.5 wt% on the chemical composition of PM emission. Furthermore, the SEM morphology suggested that KCl salts were diminished after the addition of the kaolin. These findings demonstrate the practicality of adding kaolin to mitigate PM emissions and their impacts in actual biomass combustion scenarios

Effective and fast-screening route to evaluate dynamic elastomer-filler network reversibility for sustainable rubber composite design

.The introduction of self-healing and reprocessability into conventional vulcanized rubbers has been recognized as a promising strategy to promote elastomer circularity. However, the reversibility and recovery of cross-linking polymer networks have often been assessed by static mechanical testing, which highly limits the understanding of the underlying microscale mechanisms. In this work, we investigated the network recovery of natural rubber (NR)/carbon black (CB) nanocomposites using Fourier transform (FT) rheology coupled with large amplitude oscillation shear (LAOS) technology across linear and nonlinear regimes (0.01–500%). The self-healing process of the rubber composite networks was monitored by using a programmed time–temperature oscillation shear measurement. The role of CB particle size in the filler network recovery was also discussed from the perspective of strain-induced crystallization of NR. Coupling FT-rheology and LAOS analysis, two distinct nonlinear enhancement behaviors beyond the linear viscoelastic regime were detected in the rubber nanocomposites, which were ascribed to the filler network disruption followed by the polymer network deformation. The relationship of the nonlinearity parameter I3/1 as a function of strain amplitude was selected to quantify the nonlinear rheological responses, where the role of the filler and polymer on the network recovery can therefore be differentiated. This work provides an efficient method to evaluate the self-healing and reprocessability of cross-linked rubbers and offers a fast-screen route for formulation development and sustainable rubber composite design