Witnessing and re-enacting in Cambodia: reflection on shifting testimonies

Thirty years after the collapse of the Khmer Rouge regime (1975-1979) how do Cambodians cope with the traumatic legacy of Pol Pot's reign of terror? What forms does witnessing take on in post-socialist and transitional Cambodia as senior Khmer Rouge leaders await prosecution at the Cambodian Tribunal? The paper examines aspects of witnessing in today's Cambodia, expressing each in its own way the idea of the 'shifting' of witnessing: the transformation of testimonies due to time passing and contrasted systems of justice through a comparison of testimonies in the trial of the 'Pol Pot/Ieng Sary clique' (1979) and the current Cambodian Tribunal; the complex forms of witnessing emerging from participatory projects developed with Western authors in 'We want (u) to know' (documentary movie made by an international film crew with the inhabitants of the village of Thnol Lok in 2009) and 'Breaking the silence' (theatre play realised by the Dutch dramaturge Annemarie Prins that premiered in Phnom Penh in 2009 and toured Cambodia in the following years); the relationship between documentary and legal forms of witnessing through the example of Vann Nath, a survivor of S-21/Tuol Sleng, the prison where the Khmer Rouge tortured and killed thousands of their fellow countrymen. The paper analyses the difficulty Western organisers of participatory projects experienced in applying the hybrid model of transitional justice to sociocultural contexts of witnessing. Nevertheless it points out their contribution to processes of 'recognition beyond recognition' in which cultural differences in coming to terms with historical trauma are expressed and recorded

Deciphering Diseases and Biological Targets for Environmental Chemicals using Toxicogenomics Networks

Exposure to environmental chemicals and drugs may have a negative effect on human health. A better understanding of the molecular mechanism of such compounds is needed to determine the risk. We present a high confidence human protein-protein association network built upon the integration of chemical toxicology and systems biology. This computational systems chemical biology model reveals uncharacterized connections between compounds and diseases, thus predicting which compounds may be risk factors for human health. Additionally, the network can be used to identify unexpected potential associations between chemicals and proteins. Examples are shown for chemicals associated with breast cancer, lung cancer and necrosis, and potential protein targets for di-ethylhexyl-phthalate, 2,3,7,8-tetrachlorodibenzo-p-dioxin, pirinixic acid and permethrine. The chemical-protein associations are supported through recent published studies, which illustrate the power of our approach that integrates toxicogenomics data with other data types

Navigating a river by its bends. A study on transnational social networks as resources for the transformation of Cambodia

This article explores in what ways first generation Cambodian French and Cambodian American returnees create and employ the social capital available in their transnational social networks upon their return to Cambodia. The triangular interdependence between the returnees, their overseas immigrant communities and homeland society is taken as a starting point. The central argument is that Cambodian French and Cambodian American returnees build different relationships to Cambodia due to: (1) the influence of their immigrant communities in the countries of resettlement; and (2) the contexts of their exit from Cambodia. Regarding debates on the contribution of returnees to an emergent nation, findings in this multisited casestudy bring forward that ideas of return held by the three parties involved may force remigrants into transnationalism in both host and home countries. Findings also demonstrate that social capital may be seen as a resource or a restraint in the lives of returnees

Acetylcholine receptor antagonists in acute respiratory distress syndrome: much more than muscle relaxants

Acetylcholine receptor antagonists have been shown to improve outcome in patients with severe acute respiratory distress syndrome. However, it is incompletely understood how these agents improve outcome. In the current editorial, we discuss the mechanisms of action of acetylcholine receptor antagonists beyond neuromuscular blockade