Normal ordering and boundary conditions in open bosonic strings

Boundary conditions play a non trivial role in string theory. For instance the rich structure of D-branes is generated by choosing appropriate combinations of Dirichlet and Neumann boundary conditions. Furthermore, when an antisymmetric background is present at the string end-points (corresponding to mixed boundary conditions) space time becomes non-commutative there. We show here how to build up normal ordered products for bosonic string position operators that satisfy both equations of motion and open string boundary conditions at quantum level. We also calculate the equal time commutator of these normal ordered products in the presence of antisymmetric tensor background.Comment: 7 pages no figures, References adde

Glueball Regge trajectories from gauge/string duality and the Pomeron

The spectrum of light baryons and mesons has been reproduced recently by Brodsky and Teramond from a holographic dual to QCD inspired in the AdS/CFT correspondence. They associate fluctuations about the AdS geometry with four dimensional angular momenta of the dual QCD states. We use a similar approach to estimate masses of glueball states with different spins and their excitations. We consider Dirichlet and Neumann boundary conditions and find approximate linear Regge trajectories for these glueballs. In particular the Neumann case is consistent with the Pomeron trajectory.Comment: In this revised version we made some additional remarks on the text. We also included 2 more references. The glueball spectrum and Regge trajectories are unchanged. 10 pages, 2 eps figure

Normal ordering and boundary conditions for fermionic string coordinates

We build up normal ordered products for fermionic open string coordinates consistent with boundary conditions. The results are obtained considering the presence of antisymmetric tensor fields. We find a discontinuity of the normal ordered products at string endpoints even in the absence of the background. We discuss how the energy momentum tensor also changes at the world-sheet boundary in such a way that the central charge keeps the standard value at string end points.Comment: In this revised version we clarify the issue of consistency between supersymmetry and boundary conditions and stress the fact that we are considering flat space. we also add two more reference

Quaternionic and Octonionic Spinors. A Classification

Quaternionic and octonionic realizations of Clifford algebras and spinors are classified and explicitly constructed in terms of recursive formulas. The most general free dynamics in arbitrary signature space-times for both quaternionic and octonionic spinors is presented. In the octonionic case we further provide a systematic list of results and tables expressing, e.g., the relations of the octonionic Clifford algebras with the $G_2$ cosets over the Lorentz algebras, the identities satisfied by the higher-rank antisymmetric octonionic tensors and so on. Applications of these results range from the classification of octonionic generalized supersymmetries, the construction of octonionic superstrings, as well as the investigations concerning the recently discovered octonionic $M$-superalgebra and its superconformal extension.Comment: 24 pages, LaTe

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele