Henri Temianka Correspondence; (hecker)

This collection contains material pertaining to the life, career, and activities of Henri Temianka, violin virtuoso, conductor, music teacher, and author. Materials include correspondence, concert programs and flyers, music scores, photographs, and books.https://digitalcommons.chapman.edu/temianka_correspondence/3590/thumbnail.jp

The effects of donepezil in Alzheimer's disease - Results from a multinational trial

Donepezil has been shown to be well tolerated and to improve cognition and global function in patients with mild to moderately severe Alzheimer's disease (AD). The current trial was undertaken to investigate further the efficacy and safety of donepezil, in a multinational setting, in patients with mild to moderately severe AD. This 30-week, placebo-controlled, parallel-group study consisted of a 24-week, double-blind treatment phase followed by a 6-week, single-blind, placebo washout. Eight hundred and eighteen patients with mild to moderately severe AD were randomly allocated to treatment with single, daily doses of 5 or 10 mg donepezil, or placebo. The two primary efficacy measures were: a cognitive performance test, the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) and a global evaluation, the Clinician's Interview-Based Impression of Change with caregiver input (CIBIC plus). Secondary outcome measures included the Sum of the Boxes of the Clinical Dementia Rating Scale (CDR-SB), a modified Interview for Deterioration in Daily living activities in Dementia (IDDD) and a patient-rated quality of life assessment. Statistically significant improvements in cognitive and global function were observed, as evaluated by ADAS-cog and CIBIC plus, respectively, in both the 5 and 10 mg/day donepezil groups, compared with placebo. Treatment-associated changes were also observed in functional skills, as shown by improved scores on the CDR-SB and the complex-tasks component of the IDDD. A dose-response effect was evident, with the 10 mg/day donepezil group demonstrating greater benefits in all outcome measures than the 5 mg/day group. Donepezil was well tolerated by this patient population and did not produce any clinically significant laboratory test abnormalities. The results of this study confirm that donepezil is effective and well tolerated in treating the symptoms of mild to moderately severe AD

Development and Validation of an Instructional Program To Teach Observational and Recording Skills in Behavior Modification

A multimedia program for teaching observational and recording skills was developed and validated using a modified research and development model. The program consisted of two slide carousels (192 slides) with accompanying cassette tape and workbook and three supersound 8 mm cassettes with accompanying manual and monitor\u27s guide. These materials are available through the Instructional Media Center of the Exceptional Child Center, Utah State University, Logan, Utah. The model employed two phases to determine program effectiveness. Phase I was concerned with the development and formative evaluation of program materials and procedures. In Phase II the program was validated under field conditions. The effectiveness of the program was determined by comparing experimental and control groups on post-criterion test scores. The participants also filled out a questionnaire rating various aspects of the program. Validation of the program was conducted at the Utah State University Exceptional Child Center. Four Special Education and one Psychology classes were used for the main field test. The sample population was randomly selected from class roll lists of the accessible population and consisted of 40 subjects, 20 assigned to the experimental group and 20 to the control group. Each experimental subject was assigned to two sessions in order to complete the program, each session being approximately 1\ hours in length. The sessions were a maximum of four days apart, and for the majority of students were completed within a 24-hour time period. The hypothesis that the experimental group would have significantly higher posttest mean scores than the control group was tested. An F value of 129.38 was significant at the .001 level for the total program. These results support the hypothesis. On the Student Feedback Form the program was rated overall at 4.93 on a five-point scale as being highly interesting, of value to them, and an efficient way to present this material. The subjects reached criterion on the data collecting tasks presented. It was concluded from the post-criterion test and the feedback form results that this multimedia program was effective in teaching the basic concepts of observing, defining, and recording behavior

Fear Reduction Processes in Imaginal and In Vivo Flooding: A Comment on James\u27 Review

The research comparing imaginal and in vivo exposure in the treatment of clinically significant fear, recently reviewed by James (1986), is reexamined from the perspective of bioinformational theory and the concept of emotional processing. Fear is assumed to be stored in long term memory as a network of propositionally-coded information, which has to be processed if treatment is to be successful. Emotional processing is indicated by activation of fear responses and their habituation within and across treatment sessions. Consistent with the theory, our review indicates that successful treatment via imaginal and in vivo exposure is indeed related to activation and habituation of fear responses; interference with processing has a negative impact upon fear reduction, regardless of the specific treatment techniques employed. Furthermore, some apparently discrepant findings in the available research literature can be understood in terms of the theories cited. These ideas provide a useful perspective from which to plan future research efforts and to advance our understanding of the processes underlying reduction of pathological fear

Characterization of Trypanosoma brucei isolated from lymph nodes of rats

Forms of Trypanosoma brucei isolated from lymph nodes of cyclically or intravenously infected rats, at different stages of infection, were morphologically compared with the corresponding bloodstream forms. Unlike the pleomorphic bloodstream trypanosome population, the lymph node trypanosome population was essentially monomorphic and resembled the slender forms of the bloodstream. Values for the morphometric parameters indicated a position between the slender and the stumpy forms. The number of trypanosomes/ml of blood showed the well-known periodic fluctuations while the number of trypanosomes/g of lymph node remained fairly constant. Serology revealed that lymph node trypanosome populations differed antigenically from the trypanosome populations isolated simultaneously from the bloodstrea

Long Distance Transport of Ultracold Atoms using a 1D optical lattice

We study the horizontal transport of ultracold atoms over macroscopic distances of up to 20 cm with a moving 1D optical lattice. By using an optical Bessel beam to form the optical lattice, we can achieve nearly homogeneous trapping conditions over the full transport length, which is crucial in order to hold the atoms against gravity for such a wide range. Fast transport velocities of up to 6 m/s (corresponding to about 1100 photon recoils) and accelerations of up to 2600 m/s2 are reached. Even at high velocities the momentum of the atoms is precisely defined with an uncertainty of less than one photon recoil. This allows for construction of an atom catapult with high kinetic energy resolution, which might have applications in novel collision experiments.Comment: 15 pages, 8 figure

Installation of the University of Maine’s 20th President Susan J. Hunter

Dr. Susan J. Hunter was installed as UMaine’s 20th and first female president during an inauguration ceremony held at the Collins Center for the Arts on March 26, 2015. The keynote address “Leading with a Cause,” was given by Dr. Nancy L. Zimpher, Chancellor of the State University of New York System. Click the blue download button for an unedited, machine-generated English language transcript for this recording

Collective excitations of a degenerate gas at the BEC-BCS crossover

We study collective excitation modes of a fermionic gas of $^6$Li atoms in the BEC-BCS crossover regime. While measurements of the axial compression mode in the cigar-shaped trap close to a Feshbach resonance confirm theoretical expectations, the radial compression mode shows surprising features. In the strongly interacting molecular BEC regime we observe a negative frequency shift with increasing coupling strength. In the regime of a strongly interacting Fermi gas, an abrupt change in the collective excitation frequency occurs, which may be a signature for a transition from a superfluid to a collisionless phase.Comment: Feshbach resonance position updated, few minor change

O-17 Hyperfine Spectroscopy Reveals Hydration Structure of Nitroxide Radicals in Aqueous Solutions

The hydrationstructureof nitroxideradicalsin aqueoussolutionsis elucidatedby advanced17Ohyperfine(hf) spectroscopywith supportof quantumchemicalcalculationsand MD simulations.A piperidineand a pyrrolidine-basednitroxideradical are comparedand show clear differencesin the preferreddirectionalityof H-bondformation.We demonstratethat thesescenariosare best representedin17O hf spectra,wherein-planecoordinationovers-type H-bondingleads tolittle spin densitytransferon the water oxygenand smallhf couplings,whereasp-type perpendicularcoordinationgeneratesmuch larger hf couplings.Quantitativeanaly-sis of the spectrabased on MD simulationsand DFTpredictedhf parametersis consistentwith a distributionof close solvatingwater molecules,in which direction-ality is influencedby subtle steric effects of the ring andthe methyl group substituents

Speech Communication

Contains reports on six research projects.U. S. Air Force Command and Control Development Division under Contract AF19(604)-6102National Science Foundatio