Implementing a Loosely-Coupled Integrated Assessment Model in the Pegasus Workflow Management System

Integrated assessment models (IAMs) are commonly used to explore the interactions between different modeled components of socio-environmental systems (SES). Most IAMs are built in a tightly-coupled framework so that the complex interactions between the models can be efficiently implemented within the framework in a straightforward manner. However, tightly-coupled frameworks make it more difficult to change individual models within the IAM because of the high level of integration between the models. Prioritizing flexibility over computational efficiency, the IAM presented here is built using a loosely-coupled framework and implemented in the Pegasus Workflow Management System. The modular nature of loosely-coupled systems allows each component model within the IAM to be easily exchanged for another component model from the same domain assuming each provides the same input / output interface. This flexibility allows researchers to experiment with different models for each SES component and facilitates smoother upgrades between each version of the independently developed component models

The Covenant of Sinai - the Revelation of God\u27s Mercy. A Theology of the Covenant in the Book of Exodus

Događaj Izlaska je zikkarôn - spomenčin i tvori čin vjere Židova. Savez Božji je središnji čin tog događaja spasenja. U Knjizi Izlaska opisivanje sklapanja Saveza (19 - 34) djelo je više redaktora nastalo na temelju višestoljetnih predaja. Postojao je jedan kratki temeljni tekst (Grundschrift) najbolje sačuvan u jahvističkom prikazu sklapanja Saveza. Savez je protumačen kao milosrdni Jahvin čin prema svome narodu zbog danih obećanja Abrahamu i njegovu potomstvu. Elohist je obogatio tekst prikazom misterija Božje prisutnosti i djelovanja u povijesti. Deuteronomistička predaja kroz više redakcija protumačila je Savez kao trajni čin Božjeg milosrđa i umetnula Deset zapovijedi kao dokument Saveza, a zadnji svećenički redaktor dodao je i Knjigu saveza. Svećenički prikaz u opis Saveza unio je potrebu svetosti, svetišta i kulta. Mojsije je u tekstu privilegiran u susretu s Jahvom i posrednik je Saveza. Savez je povezan i s teologijom stvaranja. Slavlje Saveza prikazano je slikom gozbe i obredom krvi kojim je izraženo zajedništvo života naroda sa živim Bogom. Subota je božanska ustanova i znak je vječnog Saveza. Prekršaj Saveza (Izl 32) reinterpretacija je vjerskog i narodnog raskola iz vremena Jeroboama I. Mojsije je zagovornik oproštenja pred Jahvom jer milosrđe pripada biti Jahvina identiteta. Oproštenje je u funkciji obnovljenog Saveza koji je u biti objava Božjeg milosrđa i interpretacija prve istine Dekaloga.The event of the exodus, as depicted in the Book of Exodus, is zikkarôn a memorial and constitutes the faith of Jews. God\u27s covenant is the central act of the redempting experience. The narrative of the Covenant at Mount Sinai in the Book of Exodus (chapters 19-34) is the work of several redactors who reshaped centuries old traditions. Contemporary researchers of the Old Testament assume the existence of a brief fundamental text (Grundschrift) which is best preserved in the Yahwistic account of the covenant narrative. In it, the covenant is explained as Yahweh\u27s merciful act in favor of his people, based on promises granted to Abraham and his progeny. The Elohist redactor enriched the text by presenting the mystery of God\u27s presence and activity in the his- ton/ of God\u27s people. Deuteronomic redaction interprets the covenant as an enduring action of God\u27s mercy and inserted the Ten Commandments as a Document of the Covenant, while the final redactor added the Book of the Covenant. Priestly account of the Covenant Code included the indispensability of holiness, the central shrine and worship. Moses was entrusted with performing the encounter with Yahweh and to mediate the covenant. The making of the covenant is related to the theology of creation. It is depicted in the form of a banquet and the sprinkling of blood which reflects Israel\u27s life fellowship with the living God. The Shabbat is the eternal sign of the covenant. The golden calf episode (Ex 32) is a reinterpretation of national and religious schism during the reign of Jeroboam I. In this episode Moses intercedes with Yahweh to forgive his people\u27s sin. Mercy is an integral part of Yahweh\u27s very selfhood. The forgiveness leads to restoration of the covenant which in essence is the revelation of God\u27s mercy and interpretation of the first Commandment which strongly asserts that Yahweh is the only deity for Israel

Behavioral Use Licensing for Responsible AI

Scientific research and development relies on the sharing of ideas and artifacts. With the growing reliance on artificial intelligence (AI) for many different applications, the sharing of code, data, and models is important to ensure the ability to replicate methods and the democratization of scientific knowledge. Many high-profile journals and conferences expect code to be submitted and released with papers. Furthermore, developers often want to release code and models to encourage development of technology that leverages their frameworks and services. However, AI algorithms are becoming increasingly powerful and generalized. Ultimately, the context in which an algorithm is applied can be far removed from that which the developers had intended. A number of organizations have expressed concerns about inappropriate or irresponsible use of AI and have proposed AI ethical guidelines and responsible AI initiatives. While such guidelines are useful and help shape policy, they are not easily enforceable. Governments have taken note of the risks associated with certain types of AI applications and have passed legislation. While these are enforceable, they require prolonged scientific and political deliberation. In this paper we advocate the use of licensing to enable legally enforceable behavioral use conditions on software and data. We argue that licenses serve as a useful tool for enforcement in situations where it is difficult or time-consuming to legislate AI usage. Furthermore, by using such licenses, AI developers provide a signal to the AI community, as well as governmental bodies, that they are taking responsibility for their technologies and are encouraging responsible use by downstream users

The preference for Europe: public opinion about European integration since 1952

To determine how public opinion matters for the politics of European integration, we need to know what Europeans say about Europe. Yet, despite a proliferation of analyses of public support for Europe, fundamental questions remain. First, does aggregate opinion reflect a single preference for Europe? Second, is the content of opinions similar across countries? Third, have opinions about Europe become more structured over time? Finally, what are the long-term dynamics in opinions about Europe? To answer these questions, we construct a new dataset of historical public opinion since 1952 in France, Germany, Italy, and the United Kingdom. Over the long run, aggregate opinion toward Europe reflects one dominant underlying dimension and its content is similar across countries. We examine the trends in support for Europe

Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial.

BackgroundWe describe the study design and protocol of a pragmatic randomized controlled trial (RCT) Acupressure for Children in Treatment for a Childhood Cancer (ACT-CC).ObjectiveTo describe the feasibility and effectiveness of an acupressure intervention to decrease treatment-related symptoms in children in treatment for cancer or recipients of a chemotherapy-based hematopoietic stem cell transplant (HSCT).DesignTwo-armed RCTs with enrollment of 5 to 30 study days.SettingTwo pediatric teaching hospitals.PatientsEighty-five children receiving cancer treatment or a chemotherapy-based HSCT each with 1 parent or caregiver.InterventionPatients are randomized 1:1 to receive either usual care plus daily professional acupressure and caregiver delivered acupressure versus usual care alone for symptom management. Participants receive up to 20 professional treatments.Main outcomeA composite nausea/vomiting measure for the child.Secondary outcomesChild's nausea, vomiting, pain, fatigue, depression, anxiety, and positive affect.Parent outcomesDepression, anxiety, posttraumatic stress symptoms, caregiver self-efficacy, and positive affect. Feasibility of delivering the semistandardized intervention will be described. Linear mixed models will be used to compare outcomes between arms in children and parents, allowing for variability in diagnosis, treatment, and age.DiscussionTrial results could help childhood cancer and HSCT treatment centers decide about the regular inclusion of trained acupressure providers to support symptom management

Efficient Identification of HIV Serodiscordant Couples by Existing HIV Testing Programs in South Brazil.

ObjectiveTo examine the feasibility of identifying HIV negative at risk individuals in HIV serodiscordant couples, during voluntary HIV testing in South Brazil.MethodsWe surveyed HIV testers at 4 public testing sites in Rio Grande do Sul. We obtained information on risk behaviors and sexual partnerships. HIV testing and testing for recent infection were performed; HIV prevalence and risk behaviors were assessed among subjects who reported having a steady partner who was HIV positive (serodiscordant group) and compared with the general testing population.ResultsAmong 3100 patients, 490 (15.8%) reported being in a steady relationship with an HIV positive partner. New HIV infections were diagnosed in 23% of the serodiscordant group (vs. 13% in the general population, p = 0.01); among newly positive subjects, recent HIV infections were more frequent (23/86, 26.7%) among testers with positive partners than among the general testing group (52/334; 15.6%; p = 0.016). Less than half of the serodiscordant testers reported having used a condom during the last sexual intercourse with their HIV-positive partner. Participants with inconsistent condom use with steady partner were four times more likely to test positive for HIV compared to those who reported always using condoms with the steady partner (OR: 4.2; 95% CI: 2.3 to 7.5).ConclusionIt is highly feasible to identify large numbers of HIV susceptible individuals who are in HIV serodiscordant relationships in South Brazil testing sites. Condom use within HIV serodiscordant couples is low in this setting, suggesting urgent need for biomedical prevention strategies to reduce HIV transmission

The Influence of Frequency Containment Reserve Flexibilization on the Economics of Electric Vehicle Fleet Operation

Simultaneously with the transformation in the energy system, the spot and ancillary service markets for electricity have become increasingly flexible with shorter service periods and lower minimum powers. This flexibility has made the fastest form of frequency regulation - the frequency containment reserve (FCR) - particularly attractive for large-scale battery storage systems (BSSs) and led to a market growth of these systems. However, this growth resulted in high competition and consequently falling FCR prices, making the FCR market increasingly unattractive to large-scale BSSs. In the context of multi-use concepts, this market may be interesting especially for a pool of electric vehicles (EVs), which can generate additional revenue during their idle times. In this paper, multi-year measurement data of 22 commercial EVs are used for the development of a simulation model for marketing FCR. In addition, logbooks of more than 460 vehicles of different economic sectors are evaluated. Based on the simulations, the effects of flexibilization on the marketing of a pool of EVs are analyzed for the example of the German FCR market design, which is valid for many countries in Europe. It is shown that depending on the sector, especially the recently made changes of service periods from one week to one day and from one day to four hours generate the largest increase in available pool power. Further reductions in service periods, on the other hand, offer only a small advantage, as the idle times are often longer than the short service periods. In principle, increasing flexibility overcompensates for falling FCR prices and leads to higher revenues, even if this does not apply across all sectors examined. A pool of 1,000 EVs could theoretically generate revenues of about 5,000 EUR - 8,000 EUR per week on the German FCR market in 2020.Comment: Preprint, 23 pages, 21 figures, 10 table

Development of efficient, integrated cellulosic biorefineries : LDRD final report.

Cellulosic ethanol, generated from lignocellulosic biomass sources such as grasses and trees, is a promising alternative to conventional starch- and sugar-based ethanol production in terms of potential production quantities, CO{sub 2} impact, and economic competitiveness. In addition, cellulosic ethanol can be generated (at least in principle) without competing with food production. However, approximately 1/3 of the lignocellulosic biomass material (including all of the lignin) cannot be converted to ethanol through biochemical means and must be extracted at some point in the biochemical process. In this project we gathered basic information on the prospects for utilizing this lignin residue material in thermochemical conversion processes to improve the overall energy efficiency or liquid fuel production capacity of cellulosic biorefineries. Two existing pretreatment approaches, soaking in aqueous ammonia (SAA) and the Arkenol (strong sulfuric acid) process, were implemented at Sandia and used to generated suitable quantities of residue material from corn stover and eucalyptus feedstocks for subsequent thermochemical research. A third, novel technique, using ionic liquids (IL) was investigated by Sandia researchers at the Joint Bioenergy Institute (JBEI), but was not successful in isolating sufficient lignin residue. Additional residue material for thermochemical research was supplied from the dilute-acid simultaneous saccharification/fermentation (SSF) pilot-scale process at the National Renewable Energy Laboratory (NREL). The high-temperature volatiles yields of the different residues were measured, as were the char combustion reactivities. The residue chars showed slightly lower reactivity than raw biomass char, except for the SSF residue, which had substantially lower reactivity. Exergy analysis was applied to the NREL standard process design model for thermochemical ethanol production and from a prototypical dedicated biochemical process, with process data supplied by a recent report from the National Research Council (NRC). The thermochemical system analysis revealed that most of the system inefficiency is associated with the gasification process and subsequent tar reforming step. For the biochemical process, the steam generation from residue combustion, providing the requisite heating for the conventional pretreatment and alcohol distillation processes, was shown to dominate the exergy loss. An overall energy balance with different potential distillation energy requirements shows that as much as 30% of the biomass energy content may be available in the future as a feedstock for thermochemical production of liquid fuels

Inferring HIV Transmission Dynamics from Phylogenetic Sequence Relationships

New insights into HIV transmission dynamics, say the authors, are likely to come from analyzing the viral sequence information that is being routinely collected during HIV genotyping

Methodological Challenges in Describing Medication Dosing Errors in Children

Summary: Although children are prescribed medications in 30 percent to 50 percent of clinic visits, little is known about medication errors in ambulatory pediatrics. In the process of completing a study to determine the prevalence of outpatient dosing errors, we identified a number of barriers to understanding the epidemiology of medication errors in children. These barriers include prescribing medication that is not labeled for use in children, discrepancies in published dosing recommendations for many medications, unclear guidelines on use of adult dosing recommendations for children of different ages and weights, and the lack of readily available documented weights to determine appropriate weight-based doses for children. In our study of pediatric medication errors, we found a wide range of doses prescribed to children for every medication we studied. Before we can truly understand medication errors in children and begin developing systems-based approaches to eliminating these errors, we need better national standards of medication doses that are appropriate for children and an improved ability to determine errors through databases that include children\u27s weights as well as prescription information