Interchange IV: Portraits

The KSU School of Music and Zuckerman Museum of Art present Interchange IV: Portraits, our fourth annual collaborative, roving recital featuring music performed in the museum. This special performance features musical works selected to correspond with artwork and concepts presented in the ZMA\u27s fall exhibitions Figure Forward and Class Pictures. Journey through the museum\u27s galleries while listening to thematically-related compositions performed by KSU faculty performers including tenor Nathan Munson, mezzo-soprano Heather Witt, clarinetist John Warren, percussionist John Lawless, and pianist Ben Wadsworth.https://digitalcommons.kennesaw.edu/musicprograms/2096/thumbnail.jp

Stories in Song : Voice Faculty Recital

The talented members of the KSU voice faculty present a special recital with the works of Britten, Schubert, and Schumann. Featured Faculty artists include: Todd Wedge, Heather Witt, Jana Young, and Dr.s Nathan Munson and Eric Jenkins.https://digitalcommons.kennesaw.edu/musicprograms/2307/thumbnail.jp

KSU Chorale, Chamber Singers and KSU Symphony Orchestra

The KSU School of Music presents a special performance featuring the KSU Symphony Orchestra, led by Director of Orchestral Studies Dr. Nathaniel Parker, and KSU Chamber Singers and University Chorale led by Dr. Leslie Blackwell, Director of Choral Activities. The program concludes with a performance of Mozart\u27s Requiem (K. 626) and will also include additional works performed during the first half: Ola Gjeilo\u27s The Rose performed by KSU Chamber Singers and Chorale and Michael Daugherty\u27s Red Cape Tango performed by KSU Symphony Orchestra.https://digitalcommons.kennesaw.edu/musicprograms/2181/thumbnail.jp

Data Services: Making it Happen

The explosion of digital research data has created exciting opportunities for librarians to engage with faculty, staff, and students in their research processes. Advances in computing, sensor technologies, and communications are challenging researchers’ abilities to find, manage, utilize, visualize, and store data. Three librarians from public Universities will describe practical approaches for developing new services, collaborations, and content to meet these needs. Real-world examples and relevant issues will be posed for group discussion

Honors Voice Recital

One of the highlights of the KSU Bailey School of Music Voice Department is the prestigious Honors Recital. Upon recommendation from our panel of applied teachers, advanced singers are selected to perform in Bailey Hall to showcase their talent. Repertoire ranges from Handel to Hoiby and Bach to Bernstein in this gala evening for friends and family accompanied by our professional collaborative pianists. These singers have the opportunity to coach with visiting professional artists such as Metropolitan Opera Mezzo Soprano, Jennifer Larmore as well as artists from the Atlanta Opera. We are proud of the high level of singing and technical training that is a hallmark of our KSU Voice Department, and we are pleased to be able to offer this wonderful evening of vocal music to the public.https://digitalcommons.kennesaw.edu/musicprograms/2389/thumbnail.jp

The role of DNA methylation in directing the functional organization of the cancer epigenome

The holistic role of DNA methylation in the organization of the cancer epigenome is not well understood. Here we perform a comprehensive, high-resolution analysis of chromatin structure to compare the landscapes of HCT116 colon cancer cells and a DNA methylation-deficient derivative. The NOMe-seq accessibility assay unexpectedly revealed symmetrical and transcription-independent nucleosomal phasing across active, poised, and inactive genomic elements. DNA methylation abolished this phasing primarily at enhancers and CpG island (CGI) promoters, with little effect on insulators and non-CGI promoters. Abolishment of DNA methylation led to the context-specific reestablishment of the poised and active states of normal colon cells, which were marked in methylation-deficient cells by distinct H3K27 modifications and the presence of either well-phased nucleosomes or nucleosome-depleted regions, respectively. At higher-order genomic scales, we found that long, H3K9me3-marked domains had lower accessibility, consistent with a more compact chromatin structure. Taken together, our results demonstrate the nuanced and context-dependent role of DNA methylation in the functional, multiscale organization of cancer epigenomes.Charles Heidelberger Memorial Fellowshi

Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3

BACKGROUND: The TCF7L2 transcription factor is linked to a variety of human diseases, including type 2 diabetes and cancer. One mechanism by which TCF7L2 could influence expression of genes involved in diverse diseases is by binding to distinct regulatory regions in different tissues. To test this hypothesis, we performed ChIP-seq for TCF7L2 in six human cell lines. RESULTS: We identified 116,000 non-redundant TCF7L2 binding sites, with only 1,864 sites common to the six cell lines. Using ChIP-seq, we showed that many genomic regions that are marked by both H3K4me1 and H3K27Ac are also bound by TCF7L2, suggesting that TCF7L2 plays a critical role in enhancer activity. Bioinformatic analysis of the cell type-specific TCF7L2 binding sites revealed enrichment for multiple transcription factors, including HNF4alpha and FOXA2 motifs in HepG2 cells and the GATA3 motif in MCF7 cells. ChIP-seq analysis revealed that TCF7L2 co-localizes with HNF4alpha and FOXA2 in HepG2 cells and with GATA3 in MCF7 cells. Interestingly, in MCF7 cells the TCF7L2 motif is enriched in most TCF7L2 sites but is not enriched in the sites bound by both GATA3 and TCF7L2. This analysis suggested that GATA3 might tether TCF7L2 to the genome at these sites. To test this hypothesis, we depleted GATA3 in MCF7 cells and showed that TCF7L2 binding was lost at a subset of sites. RNA-seq analysis suggested that TCF7L2 represses transcription when tethered to the genome via GATA3. CONCLUSIONS: Our studies demonstrate a novel relationship between GATA3 and TCF7L2, and reveal important insights into TCF7L2-mediated gene regulation

Efficacy of pre and rehabilitation in radical cystectomy on health related quality of life and physical function:A systematic review

OBJECTIVE: The efficacy of prehabilitation or rehabilitation interventions on radical cystectomy (RC) patient reported outcomes (PROs), and patient centered outcome has not yet been thoroughly explored in prior reviews, therefore the aim of this review is to evaluate the efficacy of a single or multi-modal prehabilitation or/and postoperative rehabilitation interventions compared to standard treatment on postoperative complications after RC. METHODS: We performed a three-step search strategy in PubMed, Cinahl, Embase, Cochrane Library, and Web of Science. We used Covidence for the screening of articles, risk of bias assessment, and data-extraction. GRADE was used to assess the risk of bias in outcomes across studies. Where meta-analysis was possible, we used the random effect method due to substantial heterogeneity. The remaining outcomes were summarized narratively RESULTS: We identified fourteen studies addressing one of the outcomes. None of the studies provided evidence to support that prehabilitation and/or rehabilitation interventions can improve global health related quality of life (HRQoL) in RC surgery or can reduce postoperative complications significantly. However, preoperative and postoperative education in stoma care can significantly improve self-efficacy and we found significant added benefits of sexual counseling to intracavernous injections compared to injection therapy alone. Likewise, an intensive smoking and alcohol cessation intervention demonstrated a significant effect on quit rates. Physical exercise is feasible and improves physical functioning although it does not reduce the postoperative complications. CONCLUSIONS: Currently, no evidence of efficacy of prehabilitation and/or rehabilitation interventions to improve the overall HRQoL or postoperative complications after RC exists. We found evidence that education in stoma care improved self-efficacy significantly. Adequately powered randomized controlled trials (RCTs) are needed to generate high-quality evidence in this field

Kennesaw State University Men\u27s Ensemble, Chorale, and Chamber Singers, Sacred Music of Fauré and Mozart

This KSU School of Music performance by the KSU Men\u27s Ensemble, Chorale, and Chamber Singers led by Director of Choral Activities, Dr. Leslie Blackwell, features Gabriel Fauré\u27s Requiem and Mozart\u27s Vesperae solennes de confessore (K. 339) with guest organist Brian Parks.https://digitalcommons.kennesaw.edu/musicprograms/2105/thumbnail.jp