515 research outputs found
Smoking as an early risk factor for problematic parenting practices
Parenting among those who use non-illicit and more common drugs such as cigarettes remains an understudied area for investigation. Secondary data analyses were performed in 2015 on a prospective study with parent and twin data available on n=3,009 individual members of female twin pairs born between July 1975 and June 1985 identified from Missouri-state birth records. Maternal smoking when the twins were 3+ years of age remained a significant predictor of offspring report of childhood sexual abuse (OR, 1.40; 95% CI, 1.02-1.92) after controlling for key covariates. Given limited public health resources, mothers who smoke during child's preschool years may be targeted for tailored parenting intervention
Early use of alcohol, tobacco, and illicit substances: Risks from parental separation and parental alcoholism
Genetic architecture of smoking behavior: A study of Finnish adult twins
64 Twin Research and Human Genetics Volume 9 Number 1 pp. 64–72 Both genetic and environmental factors affectsmoking initiation and maintenance, but less is known about the genetic architecture of various other smoking-related behaviors. The aim of this study is to examine the genetic architecture of smoking behavior in a large twin cohort. Questionnaires with an exten-sive smoking history section were mailed to same-sex adult twins of the Finnish twin cohort. The final study population included 2923 monozygotic and 6018 dizygotic twin pairs aged 24 to 88 years. Two-stage bivariate genetic modeling of age at initiation with amount smoked (less than 20 cigarettes per day vs. 20 or more) and age at initiation with smoking cessation was done by using the Mx statistical package. For men the heritability estimate for age a
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Developing a measure of socio-cultural origins for the European Social Survey
A person’s ethnic or socio-cultural background has been shown to be an important predictor of a range of social attitudes and behaviours. Ideally, therefore, we want to capture such information alongside other demographic variables in social surveys. However, gathering information about people’s socio-cultural origins as part of a cross-national survey is complicated, not least because of the need to capture complex variation in national, ethnic and other cultural groupings prevalent across countries: The socio-cultural composition of populations vastly differs across countries. The European Social Survey (ESS), a biannual survey of cross-national attitudes and opinions conducted in over 36 European countries since 2001, in 2014/15 trialled an approach to collecting data on socio-cultural origins based on a measure of respondents’ self-reported ancestry, i.e. family origins or descent. A questionnaire item was developed which involved countries fielding the item using a country -specific showcard and recoding responses into a newly developed European Standard Classification of Cultural and Ethnic Groups (ESCEG) to create harmonised variables for comparative analysis. Following a thorough evaluation of the item’s performance it has since been decided to include the ancestry item, with some modifications, as a permanent addition to the ESS core questionnaire from Round 8 (2016/17) onwards. This report summarises findings from the evaluation conducted into the development and performance of the new ancestry item in ESS Round 7 and the recommendations made for the item’s further development and deployment. It also makes some suggestions on how to code derived variables for statistical analysis. The evaluation concluded that the item worked well across ESS countries and generated meaningful data on respondents’ socio-cultural origins. There were no significant problems with implementation reported. However, the evaluation also highlighted a number of ways in which the item could be improved especially as regards adaptation for different countries. These include improved guidance on translation, revisions to the harmonised code-frame, and more consistent treatment of sub-national socio-cultural groups. This evaluation report will be of interest both to researcher’s wishing to carry out substantive analyses using the new ESS ancestry measure and survey methodologists interested in lessons learned for the development of cross-national questionnaires and classifications
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Meta-analysis of genome-wide association studies for extraversion: Findings from the Genetics of Personality Consortium
Common and unique genetic contributions to conduct disorder and two stages of alcohol dependence development in women
Is the relationship between binge eating episodes and personality attributable to genetic factors?
Aspects of disordered eating and personality traits, such as neuroticism are correlated and, individually, heritable. We examined the phenotypic correlation between binge eating episodes and indices of personality (neuroticism, extraversion, openness to experience, agreeableness, conscientiousness and control/impulsivity). For correlations ≥ |0.20|, we estimated the extent to which genetic and environmental factors contributed to this correlation. Participants included 3446 European-American same-sex female twins from the Missouri Adolescent Female Twin Study (median age = 22 years). Binge eating episode was assessed via interview questions. Personality traits were assessed by self-report questionnaires. There was a significant moderate phenotypic correlation between binge eating episode and neuroticism (r = 0.33), as well as conscientiousness (r=−0.21) while other correlations were significant but smaller (r ranging from −0.14 to 0.14). Individual differences in binge eating episodes, neuroticism and conscientiousness were attributed to additive genetic influences (38% [95% confidence interval: 21%–53%], 45% [38%–52%], and 44% [0.33–0.55] respectively), with the remaining variance due to individual-specific environmental influences. Covariance was attributable to genetic (neuroticism r(g) = 0.37; conscientiousness r(g) = −0.22) and individual-specific environmental (neuroticism r(e) = 0.28; conscientiousness r(e) = −0.19) influences. Personality traits may be an early indicator of genetic vulnerability to a variety of pathological behaviors including binge eating episode. Furthermore, prior research documenting phenotypic correlations between eating disorder diagnoses and personality may stem from etiological overlap between these personality traits and aspects of disordered eating, such as binge eating episode
The association of genetic predisposition to depressive symptoms with non-suicidal and suicidal self-Injuries
Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age\ua0=\ua042.4\ua0years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p\ua0=\ua00.008, explained variance ranging from 0.10 to 0.16\ua0%) and, less consistently, in suicide attempts (lowest p\ua0=\ua00.04, explained variance ranging from 0.12 to 0.23\ua0%). Polygenic risk scores did not significantly predict NSSI. Results highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI
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