4,255 research outputs found
Full counting statistics of renormalized dynamics in open quantum transport system
The internal dynamics of a double quantum dot system is renormalized due to
coupling respectively with transport electrodes and a dissipative heat bath.
Their essential differences are identified unambiguously in the context of full
counting statistics. The electrode coupling caused level detuning
renormalization gives rise to a fast-to-slow transport mechanism, which is not
resolved at all in the average current, but revealed uniquely by pronounced
super-Poissonian shot noise and skewness. The heat bath coupling introduces an
interdot coupling renormalization, which results in asymmetric Fano factor and
an intriguing change of line shape in the skewness.Comment: 9 pages, 5 figure
Quantum logical gates with four-level SQUIDs coupled to a superconducting resonator
We propose a way for realizing a two-qubit controlled phase gate with
superconducting quantum interference devices (SQUIDs) coupled to a
superconducting resonator. In this proposal, the two lowest levels of each
SQUID serve as the logical states and two intermediate levels of each SQUID are
used for the gate realization. We show that neither adjustment of SQUID level
spacings during the gate operation nor uniformity in SQUID parameters is
required by this proposal. In addition, this proposal does not require the
adiabatic passage or a second-order detuning and thus the gate is much faster.Comment: 6 pages, 3 figure
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EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs.
BackgroundPolycomb Repressive Complex 2 (PRC2) catalyzes histone methylation at H3 Lys27, and plays crucial roles during development and diseases in numerous systems. Its catalytic subunit EZH2 represents a key nuclear target for long non-coding RNAs (lncRNAs) that emerging to be a novel class of epigenetic regulator and participate in diverse cellular processes. LncRNAs are characterized by high tissue-specificity; however, little is known about the tissue profile of the EZH2- interacting lncRNAs.ObjectiveHere we performed a global screening for EZH2-binding lncRNAs in tissues including brain, lung, heart, liver, kidney, intestine, spleen, testis, muscle and blood by combining RNA immuno- precipitation and RNA sequencing. We identified 1328 EZH2-binding lncRNAs, among which 470 were shared in at least two tissues while 858 were only detected in single tissue. An RNA motif with specific secondary structure was identified in a number of lncRNAs, albeit not in all EZH2-binding lncRNAs. The EZH2-binding lncRNAs fell into four categories including intergenic lncRNA, antisense lncRNA, intron-related lncRNA and promoter-related lncRNA, suggesting diverse regulations of both cis and trans-mechanisms. A promoter-related lncRNA Hnf1aos1 bound to EZH2 specifically in the liver, a feature same as its paired coding gene Hnf1a, further confirming the validity of our study. In addition to the well known EZH2-binding lncRNAs like Kcnq1ot1, Gas5, Meg3, Hotair and Malat1, majority of the lncRNAs were firstly reported to be associated with EZH2.ConclusionOur findings provide a profiling view of the EZH2-interacting lncRNAs across different tissues, and suggest critical roles of lncRNAs during cell differentiation and maturation
Wilcoxon Rank-Based Tests for Clustered Data with R Package clusrank
Wilcoxon rank-based tests are distribution-free alternatives to the popular two-sample and paired t tests. For independent data, they are available in several R packages such as stats and coin. For clustered data, in spite of the recent methodological developments, there did not exist an R package that makes them available at one place. We present a package clusrank where the latest developments are implemented and wrapped under a unified user-friendly interface. With different methods dispatched based on the inputs, this package offers great flexibility in rank-based tests for various clustered data. Exact tests based on permutations are also provided for some methods. Details of the major schools of different methods are briefly reviewed. Usages of the package clusrank are illustrated with simulated data as well as a real dataset from an ophthalmological study. The package also enables convenient comparison between selected methods under settings that have not been studied before and the results are discussed
Angular Reconstruction of a Lead Scintillating-Fiber Sandwiched Electromagnetic Calorimeter
A new method called Neighbor Cell Deposited Energy Ratio (NCDER) is proposed
to reconstruct incidence position in a single layer for a 3-dimensional imaging
electromagnetic calorimeter (ECAL).This method was applied to reconstruct the
ECAL test beam data for the Alpha Magnetic Spectrometer-02 (AMS-02). The
results show that this method can achieve an angular resolution of 7.36\pm 0.08
/ \sqrt(E) \oplus 0.28 \pm 0.02 degree in the determination of the photons
direction, which is much more precise than that obtained with the
commonly-adopted Center of Gravity(COG) method (8.4 \pm 0.1 /sqrt(E) \oplus
0.8\pm0.3 degree). Furthermore, since it uses only the properties of
electromagnetic showers, this new method could also be used for other type of
fine grain sampling calorimeters.Comment: 6 pages, 8 figure
(Z)-1,3-Bis(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one
In the title molecule, C17H11Cl2N3O, the C=C bond connecting the triazole and 4-chlorophenyl groups adopts a Z geometry. The dihedral angles formed by the triazole ring and the 4-chloro substituted benzene rings are 67.3 (1) and 59.1 (1)°. The dihedral angle between the two benzene rings is 73.5 (1)°
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