The Nehari manifold for fractional systems involving critical nonlinearities

We study the combined effect of concave and convex nonlinearities on the number of positive solutions for a fractional system involving critical Sobolev exponents. With the help of the Nehari manifold, we prove that the system admits at least two positive solutions when the pair of parameters $(\lambda,\mu)$ belongs to a suitable subset of $\R^2$.Comment: To appear in Commun. Pure Applied Ana

Thermostability of Biological Systems: Fundamentals, Challenges, and Quantification

This review examines the fundamentals and challenges in engineering/understanding the thermostability of biological systems over a wide temperature range (from the cryogenic to hyperthermic regimen). Applications of the bio-thermostability engineering to either destroy unwanted or stabilize useful biologicals for the treatment of diseases in modern medicine are first introduced. Studies on the biological responses to cryogenic and hyperthermic temperatures for the various applications are reviewed to understand the mechanism of thermal (both cryo and hyperthermic) injury and its quantification at the molecular, cellular and tissue/organ levels. Methods for quantifying the thermophysical processes of the various applications are then summarized accounting for the effect of blood perfusion, metabolism, water transport across cell plasma membrane, and phase transition (both equilibrium and non-equilibrium such as ice formation and glass transition) of water. The review concludes with a summary of the status quo and future perspectives in engineering the thermostability of biological systems

Bilinear Immersed Finite Elements for Interface Problems

In this dissertation we discuss bilinear immersed finite elements (IFE) for solving interface problems. The related research works can be categorized into three aspects: (1) the construction of the bilinear immersed finite element spaces; (2) numerical methods based on these IFE spaces for solving interface problems; and (3) the corresponding error analysis. All of these together form a solid foundation for the bilinear IFEs. The research on immersed finite elements is motivated by many real world applications, in which a simulation domain is often formed by several materials separated from each other by curves or surfaces while a mesh independent of interface instead of a body-fitting mesh is preferred. The bilinear IFE spaces are nonconforming finite element spaces and the mesh can be independent of interface. The error estimates for the interpolation of a Sobolev function in a bilinear IFE space indicate that this space has the usual approximation capability expected from bilinear polynomials, which is O(h2) in L2 norm and O(h) in H1 norm. Then the immersed spaces are applied in Galerkin, finite volume element (FVE) and discontinuous Galerkin (DG) methods for solving interface problems. Numerical examples show that these methods based on the bilinear IFE spaces have the same optimal convergence rates as those based on the standard bilinear finite element for solutions with certain smoothness. For the symmetric selective immersed discontinuous Galerkin method based on bilinear IFE, we have established its optimal convergence rate. For the Galerkin method based on bilinear IFE, we have also established its convergence. One of the important advantages of the discontinuous Galerkin method is its flexibility for both p and h mesh refinement. Because IFEs can use a mesh independent of interface, such as a structured mesh, the combination of a DG method and IFEs allows a flexible adaptive mesh independent of interface to be used for solving interface problems. That is, a mesh independent of interface can be refined wherever needed, such as around the interface and the singular source. We also develop an efficient selective immersed discontinuous Galerkin method. It uses the sophisticated discontinuous Galerkin formulation only around the locations needed, but uses the simpler Galerkin formulation everywhere else. This selective formulation leads to an algebraic system with far less unknowns than the immersed DG method without scarifying the accuracy; hence it is far more efficient than the conventional discontinuous Galerkin formulations