Radioimmunotargeting : Some Recent Advances

Several new aspects of radioimmunotargeting for neoplastic lesions are reviewed in this paper. These include the use of single domain antibody, oncogene-coded protein and other intracellular targets so as to obtain pancarcinoma reactivity, newer methods of linking /sup 99m/Tc to antibodies for radioimmunoscintigraphy. The selection of candidate radionuclides for radioimmunotherapy, particularly the possible use of radiosilver and radiogold, and the strategies of enhanced tumour targeting were also reviewed

Fine Features in the Primordial Power Spectrum

A possible origin of the anomalous dip and bump in the primordial power spectrum, which are reconstructed from WMAP data corresponding to the multipole $\ell=100\sim 140$ by using the inversion method, is investigated as a consequence of modification of scalar field dynamics in the inflation era. Utilizing an analytic formula to handle higher order corrections to the slow-roll approximation, we evaluate the relation between a detailed shape of inflaton potential and a fine structure in the primordial power spectrum. We conclude that it is unlikely to generate the observed dip and bump in the power spectrum by adding any features in the inflaton potential. Though we can make a fine enough shape in the power spectrum by controlling the feature of the potential, the amplitude of the dip and bump becomes too small in that case.Comment: 15 pages, 11 figures, submitted to JCA

Perturbation Theory in k-Inflation Coupled to Matter

We consider k-inflation models where the action is a non-linear function of both the inflaton and the inflaton kinetic term. We focus on a scalar-tensor extension of k-inflation coupled to matter for which we derive a modified Mukhanov-Sasaki equation for the curvature perturbation. Significant corrections to the power spectrum appear when the coupling function changes abruptly along the inflationary trajectory. This gives rise to a modification of Starobinsky's model of perturbation features. We analyse the way the power spectrum is altered in the infrared when such features are present.Comment: 20 pages, 1 figur

Can slow roll inflation induce relevant helical magnetic fields?

We study the generation of helical magnetic fields during single field inflation induced by an axial coupling of the electromagnetic field to the inflaton. During slow roll inflation, we find that such a coupling always leads to a blue spectrum with $B^2(k) \propto k$, as long as the theory is treated perturbatively. The magnetic energy density at the end of inflation is found to be typically too small to backreact on the background dynamics of the inflaton. We also show that a short deviation from slow roll does not result in strong modifications to the shape of the spectrum. We calculate the evolution of the correlation length and the field amplitude during the inverse cascade and viscous damping of the helical magnetic field in the radiation era after inflation. We conclude that except for low scale inflation with very strong coupling, the magnetic fields generated by such an axial coupling in single field slow roll inflation with perturbative coupling to the inflaton are too weak to provide the seeds for the observed fields in galaxies and clusters.Comment: 33 pages 6 figures; v4 to match the accepted version to appear in JCA

BINGO: A code for the efficient computation of the scalar bi-spectrum

We present a new and accurate Fortran code, the BI-spectra and Non-Gaussianity Operator (BINGO), for the efficient numerical computation of the scalar bi-spectrum and the non-Gaussianity parameter f_{NL} in single field inflationary models involving the canonical scalar field. The code can calculate all the different contributions to the bi-spectrum and the parameter f_{NL} for an arbitrary triangular configuration of the wavevectors. Focusing firstly on the equilateral limit, we illustrate the accuracy of BINGO by comparing the results from the code with the spectral dependence of the bi-spectrum expected in power law inflation. Then, considering an arbitrary triangular configuration, we contrast the numerical results with the analytical expression available in the slow roll limit, for, say, the case of the conventional quadratic potential. Considering a non-trivial scenario involving deviations from slow roll, we compare the results from the code with the analytical results that have recently been obtained in the case of the Starobinsky model in the equilateral limit. As an immediate application, we utilize BINGO to examine of the power of the non-Gaussianity parameter f_{NL} to discriminate between various inflationary models that admit departures from slow roll and lead to similar features in the scalar power spectrum. We close with a summary and discussion on the implications of the results we obtain.Comment: v1: 5 pages, 5 figures; v2: 35 pages, 11 figures, title changed, extensively revised; v3: 36 pages, 11 figures, to appear in JCAP. The BINGO code is available online at http://www.physics.iitm.ac.in/~sriram/bingo/bingo.htm

Reconstruction of the primordial power spectrum from CMB data

Measuring the deviation from scale invariance of the primordial power spectrum is a critical test of inflation. In this paper we reconstruct the shape of the primordial power spectrum of curvature perturbations from the cosmic microwave background data, including the 7-year Wilkinson Microwave Anisotropy Probe data and the Atacama Cosmology Telescope 148 GHz data, by using a binning method of a cubic spline interpolation in log-log space. We find that the power-law spectrum is preferred by the data and that the Harrison-Zel'dovich spectrum is disfavored at 95% confidence level. These conclusions hold with and without allowing for tensor modes, however the simpler model without tensors is preferred by the data. We do not find evidence for a feature in the primordial power spectrum - in full agreement with generic predictions from cosmological inflation.Comment: 9 pages, 2 figures, 3 tables, JCAP style, published versio

Numerical evaluation of inflationary 3-point functions on curved field space

We extend the public CppTransport code to calculate the statistical properties of fluctuations in multiple-field inflationary models with curved field space. Our implementation accounts for all physical effects at tree-level in the 'in-in' diagrammatic expansion. This includes particle production due to time-varying masses, but excludes scenarios where the curvature perturbation is generated by averaging over the decay of more than one particle. We test our implementation by comparing results in Cartesian and polar field-space coordinates, showing excellent numerical agreement and only minor degradation in compute time. We compare our results with the PyTransport 2.0 code, which uses the same computational approach but a different numerical implementation, finding good agreement. Finally, we use our tools to study a class of gelaton-like models which could produce an enhanced non-Gaussian signal on equilateral configurations of the Fourier bispectrum. We show this is difficult to achieve using hyperbolic field-space manifolds and simple inflationary potentials

Numerical evaluation of the bispectrum in multiple field inflation

We present a complete framework for numerical calculation of the power spectrum and bispectrum in canonical inflation with an arbitrary number of light or heavy fields. Our method includes all relevant effects at tree-level in the loop expansion, including (i) interference between growing and decaying modes near horizon exit; (ii) correlation and coupling between species near horizon exit and on superhorizon scales; (iii) contributions from mass terms; and (iv) all contributions from coupling to gravity. We track the evolution of each correlation function from the vacuum state through horizon exit and the superhorizon regime, with no need to match quantum and classical parts of the calculation; when integrated, our approach corresponds exactly with the tree-level Schwinger or 'in-in' formulation of quantum field theory. In this paper we give the equations necessary to evolve all two- and three-point correlation functions together with suitable initial conditions. The final formalism is suitable to compute the amplitude, shape, and scale dependence of the bispectrum in models with |fNL| of order unity or less, which are a target for future galaxy surveys such as Euclid, DESI and LSST. As an illustration we apply our framework to a number of examples, obtaining quantitatively accurate predictions for their bispectra for the first time. Two accompanying reports describe publicly-available software packages that implement the method

Red, straight, no bends: primordial power spectrum reconstruction from CMB and large-scale structure

We present a minimally parametric, model independent reconstruction of the shape of the primordial power spectrum. Our smoothing spline technique is well-suited to search for smooth features such as deviations from scale invariance, and deviations from a power law such as running of the spectral index or small-scale power suppression. We use a comprehensive set of the state-of the art cosmological data: Planck observations of the temperature and polarisation anisotropies of the cosmic microwave background, WiggleZ and Sloan Digital Sky Survey Data Release 7 galaxy power spectra and the Canada-France-Hawaii Lensing Survey correlation function. This reconstruction strongly supports the evidence for a power law primordial power spectrum with a red tilt and disfavours deviations from a power law power spectrum including small-scale power suppression such as that induced by significantly massive neutrinos. This offers a powerful confirmation of the inflationary paradigm, justifying the adoption of the inflationary prior in cosmological analyses