4 research outputs found
Effect of a pediatric early warning system on all-cause mortality in Hospitalized pediatric patients: The epoch randomized clinical trial
- Author
- Boliver Darlene
- Dagenais Maryse
- Dryden-Palmer Karen
- Farrell Catherine
- Gander Sarah
- Gottesman Ronald
- Gray Martin
- Harris Wendy
- Hazim Malika
- Helfaer Mark
- Holland Joanna
- Hunt Elizabeth A.
- Hutchison James S.
- Joffe Ari R.
- Kotsakis Afrothite
- Lacroix Jacques
- MacLean Julie
- Moga Michael Alice
- Nadkarni Vinay
- Ninis Nelly
- Parkin Patricia C.
- Parshuram Christopher S.
- Shea Sarah
- Tomlinson George A.
- Wenderickx Bernard
- Wensley David
- Willan Andrew R.
- Willems Ariane
- Zavalkoff Samara
- Publication venue
- Scholarship@Western
- Publication date
- 13/03/2018
- Field of study
IMPORTANCE: There is limited evidence that the use of severity of illness scores in pediatric patients can facilitate timely admission to the intensive care unit or improve patient outcomes. OBJECTIVE: To determine the effect of the Bedside Paediatric Early Warning System (BedsidePEWS) on all-cause hospital mortality and late admission to the intensive care unit (ICU), cardiac arrest, and ICU resource use. DESIGN, SETTING, AND PARTICIPANTS: A multicenter cluster randomized trial of 21 hospitals located in 7 countries (Belgium, Canada, England, Ireland, Italy, New Zealand, and the Netherlands) that provided inpatient pediatric care for infants (gestational age ≥37 weeks) to teenagers (aged ≤18 years). Participating hospitals had continuous physician staffing and subspecialized pediatric services. Patient enrollment began on February 28, 2011, and ended on June 21, 2015. Follow-up ended on July 19, 2015. INTERVENTIONS: The BedsidePEWS intervention (10 hospitals) was compared with usual care (no severity of illness score; 11 hospitals). MAIN OUTCOMES AND MEASURES: The primary outcome was all-cause hospital mortality. The secondary outcome was a significant clinical deterioration event, which was defined as a composite outcome reflecting late ICU admission. Regression analyses accounted for hospital-level clustering and baseline rates. RESULTS: Among 144539 patient discharges at 21 randomized hospitals, there were 559 443 patient-days and 144539 patients (100%) completed the trial. All-cause hospital mortality was 1.93 per 1000 patient discharges at hospitals with BedsidePEWS and 1.56 per 1000 patient discharges at hospitals with usual care (adjusted between-group rate difference, 0.01 [95% CI, -0.80 to 0.81 per 1000 patient discharges]; adjusted odds ratio, 1.01 [95% CI, 0.61 to 1.69]; P =.96). Significant clinical deterioration events occurred during 0.50 per 1000 patient-days at hospitals with BedsidePEWS vs 0.84 per 1000 patient-days at hospitals with usual care (adjusted between-group rate difference, -0.34 [95% CI, -0.73 to 0.05 per 1000 patient-days]; adjusted rate ratio, 0.77 [95% CI, 0.61 to 0.97]; P =.03). CONCLUSIONS AND RELEVANCE: Implementation of the Bedside Paediatric Early Warning System compared with usual care did not significantly decrease all-cause mortality among hospitalized pediatric patients. These findings do not support the use of this system to reduce mortality
Impact of the COVID-19 pandemic on patients with paediatric cancer in low-income, middle-income and high-income countries: a multicentre, international, observational cohort study
- Author
- A K M Khairul Basher
- A M Umar
- Abdallah Elshenawy
- Abdallah R Allam
- Abdelbasit Ali
- Abdeljawad Mazloum
- Abdelrahman Azzam
- Abdelrahman Azzam
- Abdelrahman Bahaa
- AbdulBasit Fehintola
- Abdullah Eldaly
- Abdullahi Nuhu-Koko
- Abdulrahman Almjersah
- Abdulrahman Ghassan Qasem
- Abdulrahman Omar Taha
- Abdulrahman Omar Taha
- Abdulrasheed A Nasir
- Abdurahaman Aremu
- Abiodun Folashade Adekanmbi
- Abiodun Idowu Okunlola
- Abubakari Bawa Abdulai
- Ademola A Adeyeye
- Adeseye M Akinsete
- Adesoji Ademuyiwa
- Adesoji O Ademuyiwa
- Adewumi B Oyesakin
- Adnan Dağçınar
- Agata Chylinska
- Agnes Vojcek
- Agnes Vojcek
- Ahmad Al Ayed
- Ahmad Bouhuwaish
- Ahmad Mansour
- Ahmed Saleh
- Ahmed Samir
- Ahmed Sherif
- Ahmed Tawheed
- Ahmed Y Azzam
- Ahsan Nadeem
- Aishah Mughal
- Aishwarya Ashwinee
- Ajiboye L Olalekan
- Akila Muthukumar
- Akm Amirul Morshed
- Akram Ahmed
- Al-Mudeer Ali
- Alaa Ahmed
- Alaa Hamdan
- Alaa Hamdan
- Alan Siegel
- Alege Abdurrzzaq
- Aleksandar Stanimirovic
- Aleksandra Paunovic
- Alexander S Roth
- Alexandra Valetopoulou
- Alexandre Dukundane
- Alhassan Abdul-Mumin
- Ali Abodest
- Ali Alelayan
- Ali Hammed
- Almahmod Alkhalil
- Almed Moussa
- Alonja Reiter
- Alqasim Abdulkarim
- Alzhraa Salah Abbas
- Amani Alamre
- Amanpreet Brar
- Amer Harky
- Aminat Akinoso
- Aminu Muhammed Umar
- Ammar Al-Basiti
- Ammar Ayman
- Ammar Ayman
- Ammar Omran
- Amon Ngongola
- Amon Ngongola
- Amos Hp Loh
- Amr Mohammed Elsayed Yousf
- Andrea Hayes-Jordan
- Andrea Mingoli
- Andreea C Matei
- Andrew Nwankwo Osuigwe
- Anette S Jacobsen
- Anfel Bouderbala
- Anfel Bouderbala
- Anjan Madasu
- Anna Casey
- Anna Maria Testi
- Anneqa Tahir
- Annette Jacobsen
- Annika Heuer
- Aouabed Nesrine
- Aouabed Nesrine
- Arda Isik
- Ariana Axiaq
- Arissa Ikeda
- Arkha Yasser
- Armin Nazari
- Arshiya Adhnon
- Ashfaque Nabi
- Ashrarur Rahman Mitul
- Ashrarur Rahman Mitul
- Asim Noor Rana
- Asim Noor Rana
- Asimina Galli-Tsinopoulou
- Asmaa A M Albanna
- Assimina Galli-Tsinopoulou
- Athanasios Tragiannidis
- Atiqa Amirali
- Aubrey L Pagaduan
- Augusto Zani
- Augusto Zani
- Aya Sabry Mortada
- Aya Zazo
- Ayah Al Shraideh
- Ayah Bassam Ibrahim
- Ayat M Saadeldin
- Ayesha Mehmood
- Ayesha Saleem
- Ayman Meelad
- Ayten Saraçoğlu
- Azad Patel
- Azrina Syarizad Khutubul
- Baba Jibrin
- Bardisan Gawarieh
- Bechri Hajar
- Bekir Can Kendirlioglu
- Benjamin Martin
- Benjamin Martin
- Benjamin Shou
- Biobele J Brown
- Bioud Belkacem
- Bouaoud Souad
- Boutheyna Drid
- Brahim Saada
- Brian T Craig
- Bruce Bvulani
- Bruno Cirillo
- C-Khai Loh
- Calogero Virgone
- Can Kıvrak
- Catherine Dominic
- Catherine Yang
- Chan Hon Chui
- Charlotte Smith
- Chisom Adaobi Nri-Ezedi
- Christine Nitschke
- Christopher O Bode
- Christopher S Lukong
- Danelle Erwee
- Danica Grujicic
- Daniel Rhee
- Daniel Robinson
- Darica Au
- Dauda E Suleiman
- Dave R Lal
- Dayang Anita Abdul Aziz
- Dayang Anita Abdul Aziz
- Denis Cozzi
- Dennis Mazingi
- Dhruv Nath Ghosh
- Dhruv Nath Ghosh
- Diella Munezero
- Divya Parwani
- Doris Lau
- Dragana Janic
- Duha Jasim
- Dupe S Ademola-Popoola
- Edamisan O Temiye
- Edmund M Der
- Ehab Alameer
- Ehab Alameer
- Ehab El Refaee
- Ehab Hanafy
- Ekram Sharashi
- El Ouahabi Abdessamad
- Elaine Carrolan
- Eleni Tsotridou
- Elif Akova
- Elliott H Taylor
- Elvercio Pereira de Oliveira Junior
- Eman Abdulwahed
- Eman Ibrahim Hager
- Eman Salem Muftah Burzeiza
- Eman Seif Alnaser Solimam
- Emily Christison-Lagay
- Emmanuel A Ameh
- Emmanuel Hatzipantelis
- Emmanuel Uwiringiyimana
- Eric Mwangi Irungu
- Eric Okechukwu Umeh
- Eric W Etchill
- Essam Elhalaby
- Evren Aydogmus
- Ezekiel I Ajayi
- Fabianne Altruda de Moraes Costa Carlesse
- Fabiola Leonelli Diz
- Fakher Rahim
- Farah Sameer Yahya
- Faris Abu Za'nouneh
- Faris Ayasra
- Faris Ayasra
- Fashie Andrew Patrick
- Fatema Naser Al Fayez
- Fatema Sayed
- Fatima Ambreen Imran
- Fatma Mohammed Masoud
- Fatma Saleh Benkhial
- Fatumata Jalloh
- Fayza Haider
- Fayza Haider
- Felix M Alakaloko
- Fernanda Ferreira da Silva Lima
- Fernanda Kelly Marques de Souza
- Fernanda Lobo
- Francesco Pata
- Francis A Abantanga
- Francis Abantanga Georgios Tsoulfas
- Gabriela Guillén
- Gaetano Gallo
- Gamal Amira
- George C Ihediwa
- Ghazwani Salman
- Ghazwani Salman
- Ghazwani Yahia
- Ghita Chaoui
- Gilbert B Bonsaana
- Gioia Brachini
- Global Health Research Group on Children’s Non-Communicable Diseases Collaborative: Soham Bandyopadhyay
- Guido Seitz
- Gul Kalra
- Gul Kalra
- Gustavo Mendonça Ataíde Gomes
- Gül Nihal Özdemir
- Gül Çakmak
- Hafeez Abdelhafeez
- Hajar Benaouda
- Hajar Moujtahid
- Hajier Salim Alrashed
- Halwani Yaninga Fuseini
- Hamidah Alias
- Hamza AlNaggar
- Hani Humad
- Harmit Ghattaura
- Hassan Alalami
- Hazim Ababneh
- Hazim Elfatih
- Heidi Barola
- Helga Nauhaus
- Hend Mohammed Masoud
- Hessissen Laila
- Hira Khalid Zuberi
- Hira Zuberi
- Hoda Tawel
- Hritik Nautiyal
- Humaida Hemlae
- Hytham K S Hamid
- Ibiyeye Taiye Taibat
- Ibrahim Sallam
- Ibukunolu Olufemi Ogundele
- Igor Lazic
- Igor Lima Buarque
- Imane Ammouze
- Imogen Harrison
- Isaac Dare Olulana
- Isadora Schwaab Guerini
- Israel Fernandez Pineda
- Ivan Bogdanovic
- Iyad Sultan
- Iyad Sultan
- J Benjamin
- J Hudson Barnett
- Jacqueline Elizabeth Montoya Vásquez
- Jake A Kloebe
- Jan Godzinsky
- Janice Hui Ling Wong
- Janita Zarrish
- Jasmin Meyer
- Jessica Luyt
- Jingdan Fan
- Joana Mafalda Monteiro
- John George Massoud
- John Mathew
- Joshua Erhabor
- José Andrés Molino
- Juan Luis García León
- Judith Lindbert
- Justina O Seyi-Olajide
- Kalu Ukoha
- Kamel Hamizi
- Kamrun Nahar
- Kareem O Musa
- Karl-Heinz Frosch
- Kashaf Turk
- Kate Cross
- Kazeem O O Ibrahim
- Kefas John Bwala
- Keffi Mubarak Musa
- Kellie McClafferty
- Kelvin Ifeanyichukwu Egbuchulem
- Kemal Tolga Saracoglu
- Ken Muma
- Kerri Becktell
- Kevin Crow
- Khadijah O Omokanye
- Khaled Abualkher
- Khalil Ghandour
- Khozairi Waleed
- Khushman Kaur Bhullar
- KingDavid Nweze
- Kingsley Appiah Bimpong
- Kingsley Aseye Hattor
- Kirk David Wyatt
- Kirstie Wright
- Kishwer Nadeem
- Kıvılcım Karadeniz Cerit
- Kokila Lakhoo
- Kokila Lakhoo
- Kokila Lakhoo
- Kokila Lakhoo
- Krithi Ravi
- Kwizera Festus
- Laila Hessissen
- Leanne Gentle
- Lennart Viezens
- Leon Köpke
- Licia Portela
- Lily Saldana
- Lorraine Ochieng
- Lubna Samad
- Lubna Samad
- Lucas Garschagen de Carvalho
- Lucas Krauel
- Lucien P Jay
- Lucy Davies
- Lukman O Abdur-Rahman
- Mabroukah Saeid Alshamikh
- Mahan Salehi
- Mahmoud Adly
- Mahmoud Ahmed Ebada
- Mahmoud Bassiony
- Mahmoud Elfiky
- Mahmoud M Saad
- Mahmoud Maher Abdelnaby Alrahawy
- Manasi Shirke
- Marc Dreimann
- Marco Aurelio Ciriaco Padilha
- Maria do Bom-Sucesso
- Maria Teresa Peña Gallardo
- Mariam Lami
- Marianne Monteiro Garrigo
- Maricarmen Olivos
- Marta de Andres Crespo
- Martin Stangenberg
- Martina Zambon
- Marwa Biala
- Marwa Shelft
- Mary Joan Kpiniong
- Maryam Ghavami Adel
- Maryam Khan
- Masooma Rana
- Matthew H V Byrne
- Matthew R Schuelke
- Matthias Priemel
- Max Pachl
- Max Pachl
- Max Pachl
- Mayara Caroline Amorim Fanelli
- Mayara Fanelli
- Md Afruzul Alam
- Md Asaduzzaman
- Md Asif Iqbal
- Md Hasanuzzaman
- Md Masud Rana
- Mebarki Malika
- Megan Murphy
- Mehdi Anouar Zekkour
- Mehdi Khan
- Mehdi Khan
- Mehnaz Akter
- Meryem Gounni
- Michael Boettcher
- Michael O Adegboye
- Mihailo Milicevic
- Mihir Sheth
- Milind Chitnis
- Milind Chitnis
- Mitchelle Obat
- Moawia Mohammed Ali Elhassan
- Mohamad K Abou Chaar
- Mohamad K Abou Chaar
- Mohamed Abdel-Maboud
- Mohamed Abdelwahab
- Mohamed Adwi
- Mohamed Ahmed
- Mohamed Bahaaeldin
- Mohamed Bella Jalloh
- Mohamed Bonna
- Mohamed El Kassas
- Mohamed Elbahnasawy
- Mohamed Gamal
- Mohamed Hassanin O'Sullivan
- Mohamed Mohamed Holail
- Mohamed Sherief
- Mohamed Yazid Kadir
- Mohamedraed Elshami
- Mohammad Ahmad
- Mohammad Ali Deeb
- Mohammad K Abou Chaar
- Mohammed A Azab
- Mohammed Miftah Faraj Almihashhish
- Mohammed Tanvir Ahammed
- Morgan Drucker
- Mostafa Qatora
- Muath Alser
- Muath Alser
- Muhammad Arshad
- Muhammad Arshad
- Muhammad Arshad
- Muhammad Rafie Raza
- Muhammad Rahil Khan
- Muhammed Elhadi
- Muhammed Elhadi
- Munawar Hraib
- Murad Almasri
- Muskaan Abdul Qadir
- Musliu Adetola Tolani
- Mustafa Sakar
- Mwangi Irungu
- N Otene ThankGod
- Nacer Khernane
- Nada Osman Yousif Elhaj
- Naema Khayyam
- Naif Al Bolowi
- Narjiss Aji
- Nathalie Galea
- Nathan Thompson
- Nazmul Islam
- Nehal Rahim
- Nellie Bell
- Nellie Patiala
- Nensi Melissa Ruzgar
- Nermin Badwi
- Nida Zia
- Nima Allafi
- Nisreen Ali
- Nitin James Peters
- Noel Peter
- Noel Peter
- Noel Peter
- Nsimire Mulanga Roseline
- Nyararai Togarepi
- Okechukwu Hyginus Ekwunife
- Okorie Ikechukwu
- Olagundoye Goke
- Olakayode Olaolu Ogundoyin
- Olanrewaju Moses
- Olayinka T Sayomi
- Olivia White
- Olubisi Olutosin Bamidele
- Olubunmi Motunrayo Fatungase
- Olubunmi Obafemi Obadaini
- Olufemi Oni
- Olumide Abiodun Elebute
- Oluseyi Oyebode Ogunsua
- Oluwasegun Joshua Afolaranmi
- Oluwaseun Ladipo-Ajayi
- Omaima El-Qurneh
- Omar Elmandouh
- Omar Hamam
- Orindom Shing Pulock
- Oudrhiri Mohammed Yassaad
- Outani Oumaima
- Pablo Velasco
- Paolo Musiu
- Paolo Sapienza
- Patricia Shinondo
- Patricia Shinondo
- Paul J Galardy
- Peter Gyamfi Kwarteng
- Philip Mari Mshelbwala
- Pierfrancesco Lapolla
- Pierfranco Cicerchia
- Pooja Kumari
- Poorvaprabha Patil
- Prasanna Gomes
- Priyansh Nathani
- R M Jeffri Ismail
- Rabbey Raza Khan
- Rachel Levinson
- Radovan Mijalcic
- Raja Mari Mohammed Nasef
- Ramsha Saleem
- Ranya M Baddourah
- Raphael N Vuille-Dit-Bille
- Raphael N Vuille-Dit-Bille
- Rasaq Olaosebikan
- Rawan Yasser Emam
- Reem Ghamgh
- Reem Mohamed Almowafy
- Reema Alnajjar
- Reto Baertschiger
- Reto M Baertschiger
- Reto M Baertschiger
- Rhea Raj
- Rhea Raj
- Ricardo Vianna de Carvalho
- Rim Elmandouh
- Rima Rahmoun
- Robert L Owen
- Robin Simpson
- Robyn Brown
- Rohan Pancharatnam
- Rohini Dutta
- Rohini Dutta
- Rohini Rajpal
- Rosanda Ilic
- Roshni Dasgupta
- Ruaa Bassam Ibrahim
- S M Rezanur Rahman
- Sabbir Karim
- Sadaf Altaf
- Sadia Muhammad
- Safia Lorabi
- Safia Lorabi
- Safia Lorabi
- Sai Pillarisetti
- Salah Eddine Oussama Kacimi
- Salma Naje Abu Teir
- Sameer Saleem Tebha
- Samson Olori
- Sana Tahir
- Sara Ali
- Sara Kader Alsaeiti
- Sarah Al-Furais
- Sarah Alfurais
- Sarah Muma
- Sarah Ullrich
- Sebastián Shu Yip
- Seham M Ragab
- Sergio López
- Sewar Elejla
- Shady Fadel
- Shahnoor Islam
- Shahnur Shah
- Shaima' Al-Dabaibeh
- Shakirullah AbdulAzeez
- Shashwat Kala
- Shatha Tailakh
- Shaun Wilson
- Sheba Mary Pognaa Kunfah
- Sherief Abdelsalam
- Sherief Ghozy
- Shireen Anne Nah
- Shireen Anne Nah
- Shweta Madhusudanan
- Shweta Madhusudanan
- Sima Ester Ferman
- Simona Meneghini
- Simone de Campos Vieira Abib
- Simone de Campos Vieira Abib
- Simone de Oliveira Coelho
- Simonede Campos Vieira Abib
- Smrithi Sriram
- Soha Zahid
- Soham Bandyopadhyay
- Soham Bandyopadhyay
- Soham Bandyopadhyay
- Somy Charuvila
- Sonal Nagras
- Sravani Royyuru
- Sreylis Nay
- Stacy Cooper
- Stefan G Holland-Cunz
- Stephanie Ajinkpang
- Suraj Gandhi
- Suraj Gandhi
- Susana Nunes
- Syeda Namayah Fatima Hussain
- Syukri Ahmad Zubaidi
- Tahmina Banu
- Tahmina Banu
- Taimur Iftikhar Qureshi
- Taiwo Akeem Lawal
- Taiwo Jones
- Tamara Elyan
- Tania Akter
- Tasmiah Tahera Aziz
- Thomas Smith
- Tijana Nastasovic
- Toqa Fahmawee
- Tufan Hicdonmez
- Tunde Talib Sholadoye
- Tybat Aliyu
- Tümay Umuroğlu
- Uduak Offiong
- Usama Eldaly
- Vaishnavi Govind
- Victor Calvagna
- Victor Calvagna
- Victor Khoury
- Vincent E Nwatah
- Vladimir Bascarevic
- Vuk Scepanovic
- Waha Rahama
- Wassem Shater
- William B Lo
- Yahya Elkaoune
- Yakubu Alfa
- Yara Hijazi
- Yasin Kara
- Yasir Al-Agele
- Yasmine El Chazli
- Yassine Zerizer
- Yousef Alalawi
- Youssef Sameh Badran
- Yuki Julius Ng
- Zain Douba
- Zannat Ara
- Zarina Abdul Latiff
- Zineb Bentounsi
- Zonaira Qayyum
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2022
- Field of study
OBJECTIVES: Paediatric cancer is a leading cause of death for children. Children in low-income and middle-income countries (LMICs) were four times more likely to die than children in high-income countries (HICs). This study aimed to test the hypothesis that the COVID-19 pandemic had affected the delivery of healthcare services worldwide, and exacerbated the disparity in paediatric cancer outcomes between LMICs and HICs. DESIGN: A multicentre, international, collaborative cohort study. SETTING: 91 hospitals and cancer centres in 39 countries providing cancer treatment to paediatric patients between March and December 2020. PARTICIPANTS: Patients were included if they were under the age of 18 years, and newly diagnosed with or undergoing active cancer treatment for Acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, Wilms' tumour, sarcoma, retinoblastoma, gliomas, medulloblastomas or neuroblastomas, in keeping with the WHO Global Initiative for Childhood Cancer. MAIN OUTCOME MEASURE: All-cause mortality at 30 days and 90 days. RESULTS: 1660 patients were recruited. 219 children had changes to their treatment due to the pandemic. Patients in LMICs were primarily affected (n=182/219, 83.1%). Relative to patients with paediatric cancer in HICs, patients with paediatric cancer in LMICs had 12.1 (95% CI 2.93 to 50.3) and 7.9 (95% CI 3.2 to 19.7) times the odds of death at 30 days and 90 days, respectively, after presentation during the COVID-19 pandemic (p<0.001). After adjusting for confounders, patients with paediatric cancer in LMICs had 15.6 (95% CI 3.7 to 65.8) times the odds of death at 30 days (p<0.001). CONCLUSIONS: The COVID-19 pandemic has affected paediatric oncology service provision. It has disproportionately affected patients in LMICs, highlighting and compounding existing disparities in healthcare systems globally that need addressing urgently. However, many patients with paediatric cancer continued to receive their normal standard of care. This speaks to the adaptability and resilience of healthcare systems and healthcare workers globally
Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic
- Author
- A M Umar
- Abdallah Elshenawy
- Abdallah R Allam
- Abdelbasit Ali
- Abdeljawad Mazloum
- Abdelrahman Azzam
- Abdelrahman Bahaa
- AbdulBasit Fehintola
- Abdulhakim Awadh SalimAl-Rawas
- Abdullahi Nuhu-Koko
- Abdulrahman AlMirza
- Abdulrahman Almjersah
- Abdulrahman Ghassan Qasem
- Abdulrahman Omar Taha
- Abdulrahman Omar Taha
- Abdurahaman Aremu
- Abiodun Folashade Adekanmbi
- Abiodun Idowu Okunlola
- Abubakari Bawa Abdulai
- Adeseye M Akinsete
- Adesoji Ademuyiwa
- Adesoji O Ademuyiwa
- Adewumi B Oyesakin
- Adnan Dağçınar
- Agata Chylinska
- Agnes Vojcek
- Agnes Vojcek
- Ahmad Al Ayed
- Ahmad Bouhuwaish
- Ahmad Ozair
- Ahmed Moussa
- Ahmed Saleh
- Ahmed Samir
- Ahmed Sherif
- Ahmed Tawheed
- Ahmed Y Azzam
- Ahsan Nadeem
- Aishah Mughal
- Aishwarya Ashwinee
- Ajiboye L Olalekan
- Akila Muthukumar
- Akm Amirul Morshed
- Akm Khairul Basher
- Akram Ahmed
- Al-Mudeer Ali
- Alaa Ahmed
- Alaa Guzlan
- Alaa Hamdan
- Alaa Hamdan
- Alan Siegel
- Aleksandar Stanimirovic
- Aleksandra Paunovic
- Alexander S Roth
- Alexandra Valetopoulou
- Alexandre Dukundane
- Alhassan Abdul-Mumin
- Ali Abodest
- Ali Al Sharqi
- Ali Farid Alelayan
- Alonja Reiter
- Alqasim Abdulkarim
- Alzhraa Salah Abbas
- Amani Alamre
- Amani Twaha
- Amanpreet Brar
- Amanpreet Brar
- Amer Harky
- Aminu Muhammed Umar
- Amir Labib
- Amit Sehrawat
- Ammar Al-Basiti
- Ammar Ayman
- Ammar Omran
- Ammar Saif AlShabibi
- Amon Ngongola
- Amon Ngongola
- Anas Shikha
- Andrea Hayes-Jordan
- Andrea Mingoli
- Andreea C Matei
- Andrew Nwankwo Osuigwe
- Anette S Jacobsen
- Anfel Bouderbala
- Anisa Al Shamsi
- Ankur Bajaj
- Ankur Bajaj
- Anna Casey
- Anna Maria Testi
- Anneqa Tahir
- Annette Jacobsen
- Annika Heuer
- Aouabed Nesrine
- Arda Isik
- Ariana Axiaq
- Arissa Ikeda
- Arkha Yasser
- Armin Nazari
- Ashfaque Nabi
- Ashrarur Rahman Mitul
- Asim Noor Rana
- Asimina Galli-Tsinopoulou
- Asmaa Am Albanna
- Assimina Galli-Tsinopoulou
- Athanasios Tragiannidis
- Atiqa Amirali
- Atique Anwar
- Atul Suroy
- Aubrey L Pagaduan
- Augusto Zani
- Ayah Al Shraideh
- Ayah Bassam Ibrahim
- Ayat M Saadeldin
- Ayesha Mehmood
- Ayesha Saleem
- Ayten Saraçoğlu
- Azad Patel
- Azrina Syarizad Khutubul Zaman
- Baba Jibrin
- Bal Krishna Ojha
- Bardisan Gawrieh
- Bashar Dawud
- Bechri Hajar
- Bekir Can Kendirlioglu
- Bekir Can Kendirlioglu
- Benjamin J O'Sullivan
- Benjamin Martin
- Benjamin Martin
- Benjamin Shou
- Bernard Mbwele
- Bibekanand Jindal
- Bikash Kumar Naredi
- Bilal Matola
- Biobele J Brown
- Bioud Belkacem
- Bobby John
- Bouaoud Souad
- Boutheyna Drid
- Brahim Saada
- Brian T Craig
- Bruce Bvulani
- Bruno Cirillo
- C-Khai Loh
- Calogero Virgone
- Can Kıvrak
- Catherine Dominic
- Catherine Yang
- Cecilia Paasche
- Chan Hon Chui
- Charlotte Smith
- Chisom Adaobi Nri-Ezedi
- Christine Nitschke
- Christopher O Bode
- Christopher S Lukong
- Danelle Erwee
- Danica Grujicic
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- Madhivanan Karthigeyan
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- Mohamad K Abou Chaar
- Mohamed Abdel-Maboud
- Mohamed Abdelwahab
- Mohamed Adwi
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- Mohammad Ahmad Almahmod Alkhalil
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- Mohammed A Azab
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- Muhammed Elhadi
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- Omar Elmandouh
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- Outani Oumaima
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- Patricia Shinondo
- Patricia Shinondo
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- Pierfranco Cicerchia
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- R M Jeffri Ismail
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- Raja Mari Mohammed Nasef
- Rajat Piplani
- Ramsha Saleem
- Ranya M Baddourah
- Raphael N Vuille-Dit-Bille
- Rasaq Olaosebikan
- Ravi Kishore
- Reem Ghamgh
- Reema Alnajjar
- Rejin Kebudi
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- Rhea Raj
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- Richa Jain
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- Rochelle Fayngor
- Rohan Pancharatnam
- Rohini Dutta
- Rosanda Ilic
- Roserahayu Idros
- Roshni Dasgupta
- Ruaa Bassam Ibrahim
- S M Rezanur Rahman
- Sabbir Karim
- Sadaf Altaf
- Sadi A Abukhalaf
- Sadia Muhammad
- Safia Lorabi
- Safia Lorabi
- Sai Pillarisetti
- Salma Naje Abu Teir
- Sameer Saleem Tebha
- Samson Olori
- Sana Tahir
- Sandeep Mohindra
- Sandip Kumar Rahul
- Santosh Kumar Mahalik
- Sara Ali
- Sara Kader Alsaeiti
- Sarah Al-Furais
- Sarah Muma
- Sarah Ullrich
- Sareya Al Sibai
- Sebastián Shu Yip
- Seham M Ragab
- Sema Bay Buyukkapu
- Sergio López
- Shady Fadel
- Shahnoor Islam
- Shaima' Al-Dabaibeh
- Shaina Kamboj
- Shashwat Kala
- Shaun Wilson
- Sheba Mary Pognaa Kunfah
- Sherief Abdelsalam
- Sherief Ghozy
- Shireen Anne Nah
- Shireen Anne Nah
- Shruti Kakkar
- Shweta Madhusudanan
- Sima Ester Ferman
- Simona Meneghini
- Simone de Campos Vieira Abib
- Simone deCamposVieira Abib
- Simone deOliveira Coelho
- Smita Kayal
- Smrithi Sriram
- Soha Zahid
- Soham Bandyopadhyay
- Soham Bandyopadhyay
- Soham Bandyopadhyay
- Soham Bandyopadhyay
- Somy Charuvila
- Sonal Nagras
- Sravani Royyuru
- Sreylis Nay
- Stacy Cooper
- Stephanie Ajinkpang
- Suraj Gandhi
- Suraj Singh
- Susana Nunes
- Swati Daniel
- Syeda Namayah Fatima Hussain
- Syukri Ahmad Zubaidi
- Tahmina Banu
- Taimur Iftikhar Qureshi
- Taiwo Akeem Lawal
- Taiwo Jones
- Tania Akter
- Tasmiah Tahera Aziz
- Taylor Ibelli
- Thomas Smith
- Tijana Nastasovic
- Toqa Fahmawee
- Tufan Hicdonmez
- Tufan Hicdonmez
- Tunde Talib Sholadoye
- Tybat Aliyu
- Tzvi Najman
- Tümay Umuroğlu
- Uduak Offiong
- Usama Eldaly
- Uttam Kumar Nath
- Vaishnavi Govind
- Victor Calvagna
- Victor Calvagna
- Victor Khoury
- Vijayendra Kumar
- Vinay Suresh
- Vincent E Nwatah
- Vishal Kumar
- Vishal Michael
- Vivek Singh
- Vladimir Bascarevic
- Vrisha Madhuri
- Vuk Scepanovic
- Waha Rahama
- Waseem Shater
- William B Lo
- William Bhatti
- Win SabaiPhyu Han
- Yahya Elkaoune
- Yakubu Alfa
- Yasin Kara
- Yasmine El Chazli
- Yassine Zerizer
- Yen Yan Lim
- Yousef Alalawi
- Youssef Sameh Badran
- Yuki Julius Ng
- Zahidah Ahmad
- Zainab Al Balushi
- Zannat Ara
- Zarina Abdul Latiff
- Zineb Bentounsi
- Zonaira Qayyum
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2022
- Field of study
Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- Abellán Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akçay Özlem
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia González
- Aleem Muhammad
- Alegre Inês
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz Amorós
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
- Aliyeva Zumrud
- Aliyu Mohammed
- Aljawder Hasan
- Allen Kate
- Almahmeed Ebrahim
- Alonso Alfredo
- Alonso Javier Etreros
- Alsamneh Muneer
- Alsayadi Ramzi
- Altinel Yuksel
- Altintoprak Fatih
- Altomare Donato F
- Alvarenga Isabella
- Alvarez Laura Jimenez
- Alvarez-Bautista Francisco Emmanuel
- Alvarez-Díez Marcos
- Alves Brenda Chayanny
- Amadigwe Rita
- Amado Andreia
- Amado Fabíola
- Amador Cristina García
- Amanullah Nazli
- Amaral Hélida Aline Tomacheski
- Amaral Luis
- Amin-Tai Hizami
- Aminu Bashiru
- Amir Ahmad Suhaimi
- Ammar Ahmed Siddique
- Ammar Mona Ahmed
- Ammendola Michele
- Ammerata Giorgio
- Amorim Edgar
- Ancans Guntis
- Anderson Tom
- Andrade Diogo
- Andrejevic Predrag
- Andrés Beatriz Díaz San
- Anestiadou Elissavet
- Ang Chin Wee
- Angelo Franceschi
- Anokhin Evgeny
- Anoldo Pietro
- Antakia Ramez
- Anton Majd
- Antonelli Serena
- Antropoli Carmine
- Anula Rocio
- Anwar Jamal
- Anyadike Florence
- Apostolakidou Magda
- Apostolidi Eirini
- Aprea Giovanni
- Arabadzhiev Angel
- Arakawa Satoshi
- Arauz Jazmin
- Aravindan U
- Aremu Abdurrahman
- Aremu Isiaka
- Argawy Osama
- Arican Can
- Arida Zahed Abu
- Armellin Claudia
- Arnaoutoglou Eleni
- Arreguy-Borges Kanthya
- Artigot Mariano
- Arturi Alessandro
- Arulappan Nirupama
- Arya Shobhit
- Arynov Ardak
- Asaad Peter
- Asano Yukio
- Ascari Francesca
- Asgarov Mohsum
- Ashmawy Soad
- Aslam Muhammad Imran
- Assimakopoulou Elena
- Assis Ana
- Astilleta Romina
- Aşkar Ahmet
- Atanasov Boyko
- Atendido Tiffany
- Athanasakis Elias
- Atici Semra Demirli
- Avellaneda Nicholas
- Avellaneda Nicolas
- Avseren Goksu
- Awead Marwa
- Ayandipo Omobolaji
- Aybar Engin
- Aydin Funda
- Aydin Gaye
- Ayoub Kusay
- Aytac Erman
- Aytaç Erman
- Azevedo Jose
- Azevedo Patricia
- Azhar Najia
- Aziz Gowhar
- Azman Zairul Azwan Mohd
- Álvarez-Llano Laura
- Ângelo Miguel Duarte
- Babatunde Olanrewaju
- Badawi Marwa
- Baek Jeong-Heum
- Baez Noelia Fernández
- Baeza-Murcia Melody
- Bagnardi Francesco
- Baharom Salahudin
- Baik Seung Hyuk
- Baimakhanov Abylai
- Bains Lovenish
- Baker Aleksandra
- Bakmaz Bernarda
- Bala Abubakar Muhammad
- Balaban Vladimir
- Balalis Dimitrios
- Balasubramaniam Dinesh
- Balathayalan Yathev
- Baldi Claudio
- Balestri Riccardo
- Balfour James
- Ballah Abubakar
- Ballian Nikiforos
- Balooshi Iman Al
- Baloyiannis Ioannis
- Bamford Richard
- Bandar Mahdi Al
- Banham Gail
- Bannoud Mohammad Hassan
- Baños Pedro Antonio Parra
- Baptista Victor
- Baral Jörg
- Barbalace Nicolas
- Barbato Giuseppe
- Barbosa Anderson
- Bareka Metaxia
- Baris Baver
- Barradas Renato
- Barreda Sara Castillo
- Barrena-Blazquez Silvestra
- Barton Jess
- Bartosiak Katarzyna
- Bashilkina Olga
- Bashir Mohammed
- Basile Raffaele
- Basnyat Pradeep
- Batool Sana
- Bautista Wilson Manuel Sánchez
- Bayhan Zülfü
- Bayo José Manuel Muros
- Bayón Raquel Álvaro
- Bánky Balázs
- Beard David
- Bedzhanyan Arkady
- Behilil Chakib
- Bekele Kebebe
- Belarmino Armin
- Belay Million
- Belev Nikolay
- Bellato Vittoria
- Beltrán de Heredia Juan
- Belvedere Angela
- Benetti Emilio
- Benetti Sara
- Bengueddach Aicha
- Benjelloun El Bachir
- Benkabbou Amine
- Bennett James
- Bensafir Salim
- Bergamini Carlo
- Bernotaite Vlada
- Beron Reinaldo Isaacs
- Bethune Robert
- Bezede Cosmin
- Beznosenko Andriy
- Bhangu Aneel
- Bhargava Aman
- Bhat Rama Rani Krishna
- Bianchi Romina
- Bianco Francesco
- Bigoni Irene
- Binetti Margherita
- Bintintan Vasile
- Biondi Alberto
- Biondo Santino Antonio
- Bisgin Tayfun
- Bisheet George
- Bissett Ian
- Biswas Jyotirmoy
- Blackwell Sue
- Blanco Pablo
- Blanco Raquel Ríos
- Blanco-Colino Ruth
- Blasco Laura Fraile
- Blazquez-Martin Alma
- Bobadilla Billy Jimenez
- Bocancia Raluca
- Boccia Giuseppe
- Bogatikov Alexander
- Bolanle Olajide Edward
- Bomfa-Barbosa Alysson
- Bompou Effrosyni
- Bonardello Michela
- Bonci Eduard-Alexandru
- Bordom Daniel Osei
- Borges Filipe
- Borghi Felice
- Boschiero Matheus Negri
- Bose Bodhisattva
- Bouchagier Konstantinos
- Boudjenan-Serradj Nabil
- Boudoux Sabrina
- Bourazani Maria
- Boyce Stephen
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bradulskis Saulius
- Brainsa Eneida
- Brandström Gustav
- Braumille Markus
- Bravo Ana Minaya
- Bravo Raquel
- Bredikhin Mikhail
- Brito Noelia
- Bruni Andrea
- Buccianti Piero
- Buchs Nicolas
- Buchwald Pamela
- Budnikova Ina
- Budrikienė Rima
- Buey Lourdes
- Buijs Louis
- Buleje Jorge Alejandro Benavides
- Burlov Nikita
- Butt Anam
- Byshetty Rajendar
- Bywater Edward
- Bzikha Ilham
- Bælum Jens Kristian
- Caballero-Delgado Javier
- Cabrera Claudia
- Cafranga Estíbaliz Gutiérrez
- Cagnazzo Federica
- Calabria Mariangela
- Calabro' Marcello
- Caliendo Domenico
- Calin Camelia
- Caliskan Cemil
- Callan Rory
- Callari Cosimo
- Caltea Mihaela
- Calvo Almudena Castro
- Camacho Amparo
- Cammarata Francesco
- Campanati Renato
- Campanelli Michela
- Campbell Marion
- Canals Lucía Otazu
- Canda Aras Emre
- Cano-Matias Auxiliadora
- Cao Victor Hugo Bruno
- Capolupo Gabriella Teresa
- Cappiello Antonio
- Capuano Marianna
- Capusan Alina
- Carannante Filippo
- Carbone Ludovico
- Cardelli Stefano
- Carden Claire
- Cardoso Diogo
- Caricato Marco
- Carlin Patricia Saez
- Carlini Massimo
- Carlos Sandra
- Carneros Virginia Jimenez
- Caroço Teresa Vieira
- Carosso Fabio
- Carpelan Anu
- Carpenter Holly
- Carrascosa-Morales Irene
- Carrie Augusto
- Carrizo Claudia
- Carta Giuseppina
- Carvalho Alexandre
- Carvello Michele
- Casanova Daniel
- Cascais Raquel
- Cassia Gabriela
- Castaldi Antonio
- Castaño Renata
- Castiglioni Simone
- Castillo Enrique Roca
- Castro Marta Cuartero
- Catalano Pablo
- Cato Liam
- Caz Esra
- Cebolla Elena Sagarra
- Cecchini Ilaria
- Celdrán Rebeca González
- Celik Hale Kefeli
- Ceretti Andrea Pisani
- Ceron Silvia Ferrer
- Cervellera Maurizio
- Cervone Carmela
- Chacko Anil
- Chandrasinghe Pramodh
- Charakopoulou Alexandra
- Chardalias Leonidas
- Chaturvedi Arun
- Chatzikomnitsa Paraskevi
- Chaudhari Abhishek
- Chaudhry Sanjay
- Chawla Tabish
- Chee Corissa
- Chen Nevin
- Cheng Kuang I
- Chiarugi Massimo
- Chisthi Meer
- Chitnis Abhishek
- Chitul Andrei
- Chmielewski Gaspard
- Cholewa Hanna
- Chornet Marta Roselló
- Chowdhary Manish
- Chowdhury Sharfuddin
- Chowdhury Sharfuddin M
- Chowdri Nisar
- Christensen Peter
- Christodoulidis Grigorios
- Chrysos Emmanuel
- Chua Lorna
- Chubukova Natlia
- Chung Jun Seong
- Church Robert
- Chwat Carina
- Ciabattari Paula
- Cianchi Fabio
- Cianci Pasquale
- Ciccarese Angelo Antonio
- Ciftci Ahmet Burak
- Cigagna Luca
- Cini Charles
- Ciotarla Danut Constantin
- Cirocchi Nicholas
- Ciubotaru Cezar
- Ciulli Cristina
- Ck Harikumar
- Clark Thomas
- Clarke Nicola
- Coccolini Federico
- Codes Lina
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- null null
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- Wright Jonathan
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- Yadav Ram Kishan
- Yadev I P
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- Yakunina Natalia
- Yalkin Ömer
- Yanishev Alexey
- Yao Hongwei
- Yazici Pinar
- Yemez Kursat
- Yew Chor Kuan
- Yiğit Direnç
- Yılmaz Gülseren
- Yilmazlar Tuncay
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
- Younes Lina
- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- Zadrożna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah Kağan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)