Chemical signatures of the Anthropocene in the Clyde Estuary, UK: sediment hosted Pb, 207/206 Pb, Total Petroleum Hydrocarbons (TPH), Polyaromatic Hydrocarbon (PAH) and Polychlorinated Bipheny (PCB) pollution records

The sediment concentrations of total petroleum hydrocarbons (TPHs), polyaromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), Pb and 207/206Pb isotope ratios were measured in seven cores from the middle Clyde estuary (Scotland, UK) with an aim of tracking the late Anthropocene. Concentrations of TPHs ranged from 34 to 4386 mg kg−1, total PAHs from 19 to 16 163 μg kg−1 and total PCBs between less than 4.3 to 1217 μg kg−1. Inventories, distributions and isomeric ratios of the organic pollutants were used to reconstruct pollutant histories. Pre-Industrial Revolution and modern non-polluted sediments were characterized by low TPH and PAH values as well as high relative abundance of biogenic-sourced phenanthrene and naphthalene. The increasing industrialization of the Clyde gave rise to elevated PAH concentrations and PAH isomeric ratios characteristic of both grass/wood/coal and petroleum and combustion (specifically petroleum combustion). Overall, PAHs had the longest history of any of the organic contaminants. Increasing TPH concentrations and a concomitant decline in PAHs mirrored the lessening of coal use and increasing reliance on petroleum fuels from about the 1950s. Thereafter, declining hydrocarbon pollution was followed by the onset (1950s), peak (1965–1977) and decline (post-1980s) in total PCB concentrations. Lead concentrations ranged from 6 to 631 mg kg−1, while 207/206Pb isotope ratios spanned 0.838–0.876, indicative of various proportions of ‘background’, British ore/coal and Broken Hill type petrol/industrial lead. A chronology was established using published Pb isotope data for aerosol-derived Pb and applied to the cores

Identification of Germline Variants in Tumor Genomic Sequencing Analysis

This Correspondence relates to the article by Li et al (Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and the College of American Pathologists. J Mol Diagn 2017, 19:4–23)

Understanding wavelength scaling in 19-cell core hollow-core photonic bandgap fibers

First experimental wavelength scaling in 19-cell core HC-PBGF indicates that the minimum loss waveband occurs at longer wavelengths than previously predicted. Record low loss (2.5dB/km) fibers operating around 2µm and gas-purging experiments are also reported

The diffusion of IP telephony and vendors' commercialisation strategies

This is a post-peer-review, pre-copyedit version of an article published in the Journal of Information Technology. The definitive publisher-authenticated version is available at the link below.The Internet telephony (IP telephony) has been presented as a technology that can replace existing fixed-line services and disrupt the telecommunications industry by offering new low-priced services. This study investigates the diffusion of IP telephony in Denmark by focusing on vendors’ commercialisation strategies. The theory of disruptive innovation is introduced to investigate vendors’ perceptions about IP telephony and explore their strategies that affect the diffusion process in the residential market. The analysis is based on interview data collected from the key market players. The study's findings suggest that IP telephony is treated as a sustaining innovation that goes beyond the typical voice transmission and enables provision of advanced services such as video telephony

Accurate loss and surface mode modeling in fabricated hollow-core photonic bandgap fibers

We present a method to reconstruct the cross-sectional profile of fabricated hollow-core photonic bandgap fibers from SEM images. For the first time, numerical simulations show a good agreement with measured loss and surface mode position

Inspection of defect-induced mode coupling in hollow-core photonic bandgap fibers using time-of-flight

We analyze defect-induced mode coupling in a hollow-core photonic bandgap fiber using time-of-flight, and show its utility in complementing optical time-domain reflectometry

Organic Pollutants, Heavy Metals and Toxicity in Oil Spill impacted Salt Marsh Sediment Cores, Staten Island, New York City, USA

Sediment cores from Staten Island's salt marsh contain multiple historical oil spill events that impact ecological health. Microtox solid phase bioassay indicated moderate to high toxicity. Multiple spikes of TPH (6524 to 9586 mg/kg) and Σ16 PAH (15.5 to 18.9 mg/kg) were co-incident with known oil spills. A high TPH background of 400–700 mg/kg was attributed to diffuse sources. Depth-profiled metals Cu (1243 mg/kg), Zn (1814 mg/kg), Pb (1140 mg/kg), Ni (109 mg/kg), Hg (7 mg/kg), Cd 15 (mg/kg) exceeded sediment quality guidelines confirming adverse biological effects. Changes in Pb206/207 suggested three metal contaminant sources and diatom assemblages responded to two contamination events. Organic and metal contamination in Saw Mill Creek Marsh may harm sensitive biota, we recommend caution in the management of the 20–50 cm sediment interval because disturbance could lead to remobilisation of pre-existing legacy contamination into the waterway

Antiresonant hollow core fiber with an octave spanning bandwidth for short haul data communications

We report an effectively single mode tubular antiresonant hollow core fiber with minimum loss of ~25 dB/km at ~1200 nm, and an extremely wide low loss transmission window (lower than 30 dB/km loss from 1000 nm to 1400 nm and 6 dB bandwidth exceeding 1000 nm). Despite the relatively large mode field diameter of 32 µm, the fiber can be interfaced to SMF28 to produce fully connectorized samples. Exploiting an excellent modal purity arising from large modal differential loss and low intermodal coupling, we demonstrate penalty-free 10G on-off keying data transmission through 100m of fiber, at wavelengths of 1065, 1565 and 1963nm

Streamer Wave Events Observed in Solar Cycle 23

In this paper we conduct a data survey searching for well-defined streamer wave events observed by the Large Angle and Spectrometric Coronagraph (LASCO) on-board the Solar and Heliospheric Observatory (SOHO) throughout Solar Cycle 23. As a result, 8 candidate events are found and presented here. We compare different events and find that in most of them the driving CMEs ejecta are characterized by a high speed and a wide angular span, and the CME-streamer interactions occur generally along the flank of the streamer structure at an altitude no higher than the bottom of the field of view of LASCO C2. In addition, all front-side CMEs have accompanying flares. These common observational features shed light on the excitation conditions of streamer wave events. We also conduct a further analysis on one specific streamer wave event on 5 June 2003. The heliocentric distances of 4 wave troughs/crests at various exposure times are determined; they are then used to deduce the wave properties like period, wavelength, and phase speeds. It is found that both the period and wavelength increase gradually with the wave propagation along the streamer plasma sheet, and the phase speed of the preceding wave is generally faster than that of the trailing ones. The associated coronal seismological study yields the radial profiles of the Alfv\'en speed and magnetic field strength in the region surrounding the streamer plasma sheet. Both quantities show a general declining trend with time. This is interpreted as an observational manifestation of the recovering process of the CME-disturbed corona. It is also found that the Alfv\'enic critical point is at about 10 R$_\odot$ where the flow speed, which equals the Alfv\'en speed, is $\sim$ 200 km s$^{-1}$

An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma

The incidence of human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is increasing and implicated in more than 60% of all oropharyngeal carcinomas (OPSCCs). Although whole-genome, transcriptome, and proteome analyses have identified altered signaling pathways in HPV-induced HNSCCs, additional tools are needed to investigate the unique pathobiology of OPSCC. Herein, bioinformatics analyses of human HPV(+) HNSCCs revealed that all tumors express full-length E6 and identified molecular subtypes based on relative E6 and E7 expression levels. To recapitulate the levels, stoichiometric ratios, and anatomic location of E6/E7 expression, we generated a genetically engineered mouse model whereby balanced expression of E6/E7 is directed to the oropharyngeal epithelium. The addition of a mutant PIK3CAE545K allele leads to the rapid development of pre-malignant lesions marked by immune cell accumulation, and a subset of these lesions progress to OPSCC. This mouse provides a faithful immunocompetent model for testing treatments and investigating mechanisms of immunosuppression