Laser diode initiated detonators for space applications

Ensign Bickford Aerospace Company (EBAC) has over ten years of experience in the design and development of laser ordnance systems. Recent efforts have focused on the development of laser diode ordnance systems for space applications. Because the laser initiated detonators contain only insensitive secondary explosives, a high degree of system safety is achieved. Typical performance characteristics of a laser diode initiated detonator are described in this paper, including all-fire level, function time, and output. A finite difference model used at EBAC to predict detonator performance, is described and calculated results are compared to experimental data. Finally, the use of statistically designed experiments to evaluate performance of laser initiated detonators is discussed

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser(487) in the ‘ST loop’ (serine/threonine-rich loop) within the C-terminal domain of AMPK-α1 (AMP-activated protein kinase-α1), leading to inhibition of phosphorylation by upstream kinases at the activating site, Thr(172). Surprisingly, the equivalent site on AMPK-α2, Ser(491), is not an Akt target and is modified instead by autophosphorylation. Stimulation of HEK (human embryonic kidney)-293 cells with IGF-1 caused reduced subsequent Thr(172) phosphorylation and activation of AMPK-α1 in response to the activator A769662 and the Ca(2+) ionophore A23187, effects we show to be dependent on Akt activation and Ser(487) phosphorylation. Consistent with this, in three PTEN (phosphatase and tensin homologue deleted on chromosome 10)-null tumour cell lines (in which the lipid phosphatase PTEN that normally restrains the Akt pathway is absent and Akt is thus hyperactivated), AMPK was resistant to activation by A769662. However, full AMPK activation could be restored by pharmacological inhibition of Akt, or by re-expression of active PTEN. We also show that inhibition of Thr(172) phosphorylation is due to interaction of the phosphorylated ST loop with basic side chains within the αC-helix of the kinase domain. Our findings reveal that a previously unrecognized effect of hyperactivation of Akt in tumour cells is to restrain activation of the LKB1 (liver kinase B1)–AMPK pathway, which would otherwise inhibit cell growth and proliferation

What's the point of knowing how?

Why is it useful to talk and think about knowledge-how? Using Edward Craig’s discussion of the function of the concepts of knowledge and knowledge-how as a jumping off point, this paper argues that considering this question can offer us new angles on the debate about knowledge-how. We consider two candidate functions for the concept of knowledge-how: pooling capacities, and mutual reliance. Craig makes the case for pooling capacities, which connects knowledge-how to our need to pool practical capacities. I argue that the evidence is much more equivocal. My suggested diagnosis is that the concept of knowledge-how plays both functions, meaning that the concept of knowledge-how is inconsistent, and that the debate about knowledge-how is at least partly a metalinguistic negotiation. In closing, I suggest a way to revise the philosophical concept of knowledge how

BOSS Ultracool Dwarfs I: Colors and Magnetic Activity of M and L dwarfs

We present the colors and activity of ultracool (M7-L8) dwarfs from the Tenth Data Release of the Sloan Digital Sky Survey (SDSS). We combine previous samples of SDSS M and L dwarfs with new data obtained from the Baryon Oscillation Sky Survey (BOSS) to produce the BOSS Ultracool Dwarf (BUD) sample of 11820 M7-L8 dwarfs. By combining SDSS data with photometry from the Two Micron All Sky Survey and the Wide-Field Infrared Sky Explorer mission, we present ultracool dwarf colors from $i-z$ to $W2-W3$ as a function of spectral type, and extend the SDSS-2MASS-WISE color locus to include ultracool dwarfs. The $i-z$, $i-J$, and $z-J$ colors provide the best indication of spectral type for M7-L3 dwarfs. We also examine ultracool dwarf chromospheric activity through the presence and strength of H$\alpha$ emission. The fraction of active dwarfs rises through the M spectral sequence until it reaches $\sim$90% at spectral type L0. The fraction of active dwarfs then declines to 50% at spectral type L5; no H$\alpha$ emission is observed in the late-L dwarfs in the BUD sample. The fraction of active L0-L5 dwarfs is much higher than previously observed. The strength of activity declines with spectral type from M7 through L3, after which the data do not show a clear trend. Using one-dimensional chromosphere models, we explore the range of filling factors and chromospheric temperature structures that are consistent with H$\alpha$ observations of M0-L7 dwarfs. M dwarf chromospheres have a similar, smoothly varying range of temperature and surface coverage while L dwarf chromospheres are cooler and have smaller filling factors.Comment: 24 pages and 13 figures, submitted to AJ. A short video describing these results can be found at https://www.youtube.com/watch?v=wwX5WkuJCU