77 research outputs found
Three-dimensional general relativistic hydrodynamics II: long-term dynamics of single relativistic stars
This is the second in a series of papers on the construction and validation
of a three-dimensional code for the solution of the coupled system of the
Einstein equations and of the general relativistic hydrodynamic equations, and
on the application of this code to problems in general relativistic
astrophysics. In particular, we report on the accuracy of our code in the
long-term dynamical evolution of relativistic stars and on some new physics
results obtained in the process of code testing. The tests involve single
non-rotating stars in stable equilibrium, non-rotating stars undergoing radial
and quadrupolar oscillations, non-rotating stars on the unstable branch of the
equilibrium configurations migrating to the stable branch, non-rotating stars
undergoing gravitational collapse to a black hole, and rapidly rotating stars
in stable equilibrium and undergoing quasi-radial oscillations. The numerical
evolutions have been carried out in full general relativity using different
types of polytropic equations of state using either the rest-mass density only,
or the rest-mass density and the internal energy as independent variables. New
variants of the spacetime evolution and new high resolution shock capturing
(HRSC) treatments based on Riemann solvers and slope limiters have been
implemented and the results compared with those obtained from previous methods.
Finally, we have obtained the first eigenfrequencies of rotating stars in full
general relativity and rapid rotation. A long standing problem, such
frequencies have not been obtained by other methods. Overall, and to the best
of our knowledge, the results presented in this paper represent the most
accurate long-term three-dimensional evolutions of relativistic stars available
to date.Comment: 19 pages, 17 figure
Current status of turbulent dynamo theory: From large-scale to small-scale dynamos
Several recent advances in turbulent dynamo theory are reviewed. High
resolution simulations of small-scale and large-scale dynamo action in periodic
domains are compared with each other and contrasted with similar results at low
magnetic Prandtl numbers. It is argued that all the different cases show
similarities at intermediate length scales. On the other hand, in the presence
of helicity of the turbulence, power develops on large scales, which is not
present in non-helical small-scale turbulent dynamos. At small length scales,
differences occur in connection with the dissipation cutoff scales associated
with the respective value of the magnetic Prandtl number. These differences are
found to be independent of whether or not there is large-scale dynamo action.
However, large-scale dynamos in homogeneous systems are shown to suffer from
resistive slow-down even at intermediate length scales. The results from
simulations are connected to mean field theory and its applications. Recent
work on helicity fluxes to alleviate large-scale dynamo quenching, shear
dynamos, nonlocal effects and magnetic structures from strong density
stratification are highlighted. Several insights which arise from analytic
considerations of small-scale dynamos are discussed.Comment: 36 pages, 11 figures, Spa. Sci. Rev., submitted to the special issue
"Magnetism in the Universe" (ed. A. Balogh
Autoimmune and infectious skin diseases that target desmogleins
Desmosomes are intercellular adhesive junctions of epithelial cells that contain two major transmembrane components, the desmogleins (Dsg) and desmocollins (Dsc), which are cadherin-type cell–cell adhesion molecules and are anchored to intermediate filaments of keratin through interactions with plakoglobin and desmoplakin. Desmosomes play an important role in maintaining the proper structure and barrier function of the epidermis and mucous epithelia. Four Dsg isoforms have been identified to date, Dsg1–Dsg4, and are involved in several skin and heart diseases. Dsg1 and Dsg3 are the two major Dsg isoforms in the skin and mucous membranes, and are targeted by IgG autoantibodies in pemphigus, an autoimmune disease of the skin and mucous membranes. Dsg1 is also targeted by exfoliative toxin (ET) released by Staphylococcus aureus in the infectious skin diseases bullous impetigo and staphylococcal scalded skin syndrome (SSSS). ET is a unique serine protease that shows lock and key specificity to Dsg1. Dsg2 is expressed in all tissues possessing desmosomes, including simple epithelia and myocardia, and mutations in this gene are responsible for arrhythmogenic right ventricular cardiomyopathy/dysplasia. Dsg4 plays an important adhesive role mainly in hair follicles, and Dsg4 mutations cause abnormal hair development. Recently, an active disease model for pemphigus was generated by a unique approach using autoantigen-deficient mice that do not acquire tolerance against the defective autoantigen. Adoptive transfer of Dsg3−/− lymphocytes into mice expressing Dsg3 induces stable anti-Dsg3 IgG production with development of the pemphigus phenotype. This mouse model is a valuable tool with which to investigate immunological mechanisms of harmful IgG autoantibody production in pemphigus. Further investigation of desmoglein molecules will continue to provide insight into the unsolved pathophysiological mechanisms of diseases and aid in the development of novel therapeutic strategies with minimal side effects
General Overview of Black Hole Accretion Theory
I provide a broad overview of the basic theoretical paradigms of black hole
accretion flows. Models that make contact with observations continue to be
mostly based on the four decade old alpha stress prescription of Shakura &
Sunyaev (1973), and I discuss the properties of both radiatively efficient and
inefficient models, including their local properties, their expected stability
to secular perturbations, and how they might be tied together in global flow
geometries. The alpha stress is a prescription for turbulence, for which the
only existing plausible candidate is that which develops from the
magnetorotational instability (MRI). I therefore also review what is currently
known about the local properties of such turbulence, and the physical issues
that have been elucidated and that remain uncertain that are relevant for the
various alpha-based black hole accretion flow models.Comment: To be published in Space Science Reviews and as hard cover in the
Space Sciences Series of ISSI: The Physics of Accretion on to Black Holes
(Springer Publisher
Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016
The UN’s Sustainable Development Goals (SDGs) are grounded in the global ambition of “leaving no one behind”. Understanding today’s gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016), we measured 37 of the 50 health-related SDG indicators over the period 1990–2016 for 188 countries, and then on the basis of these past trends, we projected indicators to 2030
Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
Interpretation: By quantifying levels and trends in exposures to risk factors and the resulting disease burden, this assessment offers insight into where past policy and programme efforts might have been successful and highlights current priorities for public health action. Decreases in behavioural, environmental, and occupational risks have largely offset the effects of population growth and ageing, in relation to trends in absolute burden. Conversely, the combination of increasing metabolic risks and population ageing will probably continue to drive the increasing trends in non-communicable diseases at the global level, which presents both a public health challenge and opportunity. We see considerable spatiotemporal heterogeneity in levels of risk exposure and risk-attributable burden. Although levels of development underlie some of this heterogeneity, O/E ratios show risks for which countries are overperforming or underperforming relative to their level of development. As such, these ratios provide a benchmarking tool to help to focus local decision making. Our findings reinforce the importance of both risk exposure monitoring and epidemiological research to assess causal connections between risks and health outcomes, and they highlight the usefulness of the GBD study in synthesising data to draw comprehensive and robust conclusions that help to inform good policy and strategic health planning
Avaliação das Mães de Crianças Pequenas Público-Alvo da Educação Especial sobre um Programa de Intervenção
Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing
Most transcriptome-wide association studies (TWASs) so far focus on European ancestry and lack diversity. To overcome this limitation, we aggregated genome-wide association study (GWAS) summary statistics, whole-genome sequences and expression quantitative trait locus (eQTL) data from diverse ancestries. We developed a new approach, TESLA (multi-ancestry integrative study using an optimal linear combination of association statistics), to integrate an eQTL dataset with a multi-ancestry GWAS. By exploiting shared phenotypic effects between ancestries and accommodating potential effect heterogeneities, TESLA improves power over other TWAS methods. When applied to tobacco use phenotypes, TESLA identified 273 new genes, up to 55% more compared with alternative TWAS methods. These hits and subsequent fine mapping using TESLA point to target genes with biological relevance. In silico drug-repurposing analyses highlight several drugs with known efficacy, including dextromethorphan and galantamine, and new drugs such as muscle relaxants that may be repurposed for treating nicotine addiction
Microstructural Study of<tex></tex>Films by High Resolution X-ray Diffraction
- …