Impacts of COVID-19 on Health Promotion Within Higher Education: Exploring Organizational Resilience

The close proximity of students learning, living, socializing and working on university and college campuses presents a unique setting to understand organization responses to the COVID-19 pandemic. This concurrent, mixed methods qualitative study explored how one institution of higher education demonstrated resilience and how its health promotion activities pivoted and adjusted to reduce virus transmission and maintain safety while continuing to promote learning and education. Based on the organizational resilience conceptualization developed by Duchek (2020), data collection methods combined individual interviews with university leaders, self-interview and reflection, and a review of organization documents a connection between health promotion, organization resilience, and critical incident response was found. Data analysis revealed a set of themes unique to this university, but also supports recent literature on organization resilience. Findings suggest that organization preparation, the use of reflection in the response process and the expression of organization values, (care and compassion) provide opportunities for the organization to practice adaptive resilience. In addition, the study findings suggest the importance of health promotion to assist in the critical incident response planning. The analytical process of combining stakeholder interviews, self-interviews, and organization documents provides one path for deeper learning of the connection between health promotion and organization resilience

Angiogenesis inhibitor therapies for advanced renal cell carcinoma: Toxicity and treatment patterns in clinical practice from a global medical chart review

The aim of this study was to assess the treatment patterns and safety of sunitinib, sorafenib and bevacizumab in real-world clinical settings in US, Europe and Asia. Medical records were abstracted at 18 community oncology clinics in the US and at 21 tertiary oncology centers in US, Europe and Asia for 883 patients ≥18 years who had histologically/cytologically confirmed diagnosis of advanced RCC and received sunitinib (n=631), sorafenib (n=207) or bevacizumab (n=45) as first‑line treatment. No prior treatment was permitted. Data were collected on all adverse events (AEs) and treatment modifications, including discontinuation, interruption and dose reduction. Treatment duration was estimated using Kaplan-Meier analysis. Demographics were similar across treatment groups and regions. Median treatment duration ranged from 6.1 to 10.7 months, 5.1 to 8.5 months and 7.5 to 9.8 months for sunitinib, sorafenib and bevacizumab patients, respectively. Grade 3/4 AEs were experienced by 26.0, 28.0 and 15.6% of sunitinib, sorafenib and bevacizumab patients, respectively. Treatment discontinuations occurred in 62.4 (Asia) to 63.1% (US) sunitinib, 68.8 (Asia) to 90.0% (Europe) sorafenib, and 66.7 (Asia) to 81.8% (US) bevacizumab patients. Globally, treatment modifications due to AEs occurred in 55.1, 54.2 and 50.0% sunitinib, sorafenib and bevacizumab patients, respectively. This study in a large, global cohort of advanced RCC patients found that angiogenesis inhibitors are associated with high rates of AEs and treatment modifications. Findings suggest an unmet need for more tolerable agents for RCC treatment

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Investigating public service media as hybrid arrangements

This theme issue of Media International Australia explores public service media as increasingly organised via hybrid arrangements that function at any given time according to diverse technologies, politics, people and economies, with the aim of understanding how these hybrid arrangements work and their consequences for the organisation of public media. The articles offer particular examples of hybrid arrangements at work in public service media institutions, and explore a range of questions relating to such arrangements. They also examine diverse examples of hybridity that arise when public service media strive to retain their heritage brand values while responding to new regulatory and economic environments