Youth Who Are Obese Sustain Moderate-to-Vigorous Physical Activity Intensity During Active Video Games

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The Relationship Between Lower Extremity Functional Strength and Aerobic Performance in Youth with Cerebral Palsy (CP)

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A model for the orientational ordering of the plant microtubule cortical array

The plant microtubule cortical array is a striking feature of all growing plant cells. It consists of a more or less homogeneously distributed array of highly aligned microtubules connected to the inner side of the plasma membrane and oriented transversely to the cell growth axis. Here we formulate a continuum model to describe the origin of orientational order in such confined arrays of dynamical microtubules. The model is based on recent experimental observations that show that a growing cortical microtubule can interact through angle dependent collisions with pre-existing microtubules that can lead either to co-alignment of the growth, retraction through catastrophe induction or crossing over the encountered microtubule. We identify a single control parameter, which is fully determined by the nucleation rate and intrinsic dynamics of individual microtubules. We solve the model analytically in the stationary isotropic phase, discuss the limits of stability of this isotropic phase, and explicitly solve for the ordered stationary states in a simplified version of the model.Comment: 15 pages, 5 figure

High prevalence of scrapie in a dairy goat herd: tissue distribution of disease-associated PrP and effect of PRNP genotype and age

Following a severe outbreak of clinical scrapie in 2006–2007, a large dairy goat herd was culled and 200 animals were selected for post-mortem examinations in order to ascertain the prevalence of infection, the effect of age, breed and PRNP genotype on the susceptibility to scrapie, the tissue distribution of diseaseassociated PrP (PrP$^{\rm d}$), and the comparative efficiency of different diagnostic methods. As determined by immunohistochemical (IHC) examinations with Bar224 PrP antibody, the prevalence of preclinical infection was very high (72/200; 36.0%), with most infected animals being positive for PrP$^{\rm d}$ in lymphoreticular system (LRS) tissues (68/72; 94.4%) compared to those that were positive in brain samples (38/72; 52.8%). The retropharyngeal lymph node and the palatine tonsil showed the highest frequency of PrP$^{\rm d}$ accumulation (87.3% and 84.5%, respectively), while the recto-anal mucosa-associated lymphoid tissue (RAMALT) was positive in only 30 (41.7%) of the infected goats. However, the efficiency of rectal and palatine tonsil biopsies taken shortly before necropsy was similar. The probability of brain and RAMALT being positive directly correlated with the spread of PrP$^{\rm d}$ within the LRS. The prevalence of infection was influenced by PRNP genetics at codon 142 and by the age of the goats: methionine carriers older than 60 months showed a much lower prevalence of infection (12/78; 15.4%) than those younger than 60 months (20/42; 47.6%); these last showed prevalence values similar to isoleucine homozygotes of any age (40/80; 50.0%). Two of seven goats with definite signs of scrapie were negative for PrP$^{\rm d}$ in brain but positive in LRS tissues, and one goat showed biochemical and IHC features of PrP$^{\rm d}$ different from all other infected goats. The results of this study have implications for surveillance and control policies for scrapie in goats

Stellar and circumstellar evolution of long period variable stars

In a first paper, HIPPARCOS astrometric and kinematic data were used to calibrate both infrared K and IRAS luminosities at the same time as kinematic parameters of Long Period Variable stars (LPVs). Individual estimated absolute magnitudes and a probabilistic assignation to galactic populations were deduced from these calibrations for each LPV of our sample. Here we propose a scenario of simultaneous stellar and circumstellar evolution according to the galactic populations. The transitory states of S and Tc stars allow us to confirm the location of the first dredge-up at $M_{bol}=-3.5$. There is also evidence suggesting that a previous enrichment in s-elements from a more evolved companion may accelerate the evolution along the AGB. The possible evolution to OH LPVs is included in this scenario, and any of these stars may have a mass at the limit of the capability for a C enrichment up to C/O > 1. A list of bright massive LPVs with peculiar envelope and luminosity properties is proposed as Hot Bottom Burning candidates. The He-shell flash star, R Cen, is found to be exceptionally bright and could become, before leaving the AGB, a C-rich LPV brighter than the usual luminosity limit of carbon stars.Comment: Accepted for publication in Astronomy & Astrophysic

A Fast Algorithm for Robust Regression with Penalised Trimmed Squares

The presence of groups containing high leverage outliers makes linear regression a difficult problem due to the masking effect. The available high breakdown estimators based on Least Trimmed Squares often do not succeed in detecting masked high leverage outliers in finite samples. An alternative to the LTS estimator, called Penalised Trimmed Squares (PTS) estimator, was introduced by the authors in \cite{ZiouAv:05,ZiAvPi:07} and it appears to be less sensitive to the masking problem. This estimator is defined by a Quadratic Mixed Integer Programming (QMIP) problem, where in the objective function a penalty cost for each observation is included which serves as an upper bound on the residual error for any feasible regression line. Since the PTS does not require presetting the number of outliers to delete from the data set, it has better efficiency with respect to other estimators. However, due to the high computational complexity of the resulting QMIP problem, exact solutions for moderately large regression problems is infeasible. In this paper we further establish the theoretical properties of the PTS estimator, such as high breakdown and efficiency, and propose an approximate algorithm called Fast-PTS to compute the PTS estimator for large data sets efficiently. Extensive computational experiments on sets of benchmark instances with varying degrees of outlier contamination, indicate that the proposed algorithm performs well in identifying groups of high leverage outliers in reasonable computational time.Comment: 27 page

Braneworld Cosmology in (Anti)--de Sitter Einstein--Gauss--Bonnet--Maxwell Gravity

Braneworld cosmology for a domain wall embedded in the charged (Anti)-de Sitter-Schwarzschildblack hole of the five--dimensional Einstein-Gauss-Bonnet-Maxwell theory is considered. The effective Friedmann equation for the brane is derived by introducing the necessary surface counterterms required for a well-defined variational principlein the Gauss--Bonnet theory and for the finiteness of the bulk space. The asymptotic dynamics of the brane cosmology is determined and it is found that solutions with vanishingly small spatial volume are unphysical. The finiteness of the bulk action is related to the vanishing of the effective cosmological constant on the brane. An analogy between the Friedmann equation and a generalized Cardy--Verlinde formula is drawn.Comment: LaTex file 28 pages, typos corrected, one reference is adde

Kinetics of active surface-mediated diffusion in spherically symmetric domains

We present an exact calculation of the mean first-passage time to a target on the surface of a 2D or 3D spherical domain, for a molecule alternating phases of surface diffusion on the domain boundary and phases of bulk diffusion. We generalize the results of [J. Stat. Phys. {\bf 142}, 657 (2011)] and consider a biased diffusion in a general annulus with an arbitrary number of regularly spaced targets on a partially reflecting surface. The presented approach is based on an integral equation which can be solved analytically. Numerically validated approximation schemes, which provide more tractable expressions of the mean first-passage time are also proposed. In the framework of this minimal model of surface-mediated reactions, we show analytically that the mean reaction time can be minimized as a function of the desorption rate from the surface.Comment: Published online in J. Stat. Phy

A Study of CO Emission in High Redshift QSOs Using the Owens Valley Millimeter Array

Searches for CO emission in high-redshift objects have traditionally suffered from the accuracy of optically-derived redshifts due to lack of bandwidth in correlators at radio observatories. This problem has motivated the creation of the new COBRA continuum correlator, with 4 GHz available bandwidth, at the Owens Valley Radio Observatory Millimeter Array. Presented here are the first scientific results from COBRA. We report detections of redshifted CO(J=3-2) emission in the QSOs SMM J04135+10277 and VCV J140955.5+562827, as well as a probable detection in RX J0911.4+0551. At redshifts of z=2.846, z=2.585, and z=2.796, we find integrated CO flux densities of 5.4 Jy km/s, 2.4 Jy km/s, and 2.9 Jy km/s for SMM J04135+10277, VCV J140955.5+562827, and RX J0911.4+0551, respectively, over linewidths of Delta(V_{FWHM}) ~ 350 km/s. These measurements, when corrected for gravitational lensing, correspond to molecular gas masses of order M(H_2) ~ 10^{9.6-11.1} solar masses, and are consistent with previous CO observations of high-redshift QSOs. We also report 3-sigma upper limits on CO(3-2) emission in the QSO LBQS 0018-0220 of 1.3 Jy km/s. We do not detect significant 3mm continuum emission from any of the QSOs, with the exception of a tentative (3-sigma) detection in RX J0911.4+0551 of S_{3mm}=0.92 mJy/beam.Comment: 18 pages, 5 figures, 2 tables, accepted to ApJ. Changes made for version 2: citations added, 2 objects added to Table 2 and Figure

Comparative Dosimetric Analysis and Normal Tissue Complication Probability Modelling of Four-Dimensional Computed Tomography Planning Scans Within the UK NeoSCOPE Trial

Aims: NeoSCOPE is a trial of two different neoadjuvant chemoradiotherapy regimens for resectable oesophageal cancer and was the first multicentre trial in the UK to incorporate four-dimensional computed tomography (4D-CT) into radiotherapy planning. Despite 4D-CT being increasingly accepted as a standard of care for lower third and junctional oesophageal tumours, there is limited evidence of its benefit over standard three-dimensional computed tomography (3D-CT). // Materials: Using NeoSCOPE 4D-CT cases, we undertook a dosimetric comparison study of 3D-CT versus 4D-CT plans comparing target volume coverage and dose to organs at risk. We used established normal tissue complication probability models to evaluate the potential toxicity reduction of using 4D-CT plans in oesophageal cancer. // Results: 4D-CT resulted in a smaller median absolute PTV volume and lower dose levels for all reported constraints with comparable target volume coverage. NTCP modelling suggests a significant relative risk reduction of cardiac and pulmonary toxicity endpoints with 4D-CT. // Conclusion: Our work shows that incorporating 4D-CT into treatment planning may significantly reduce the toxicity burden from this treatment