Concert recording 2021-10-30

[Track 1]. The song of King David / Norman Bolter-- [Track 2]. O mio babbino caro / Giacomo Puccini -- [Track 3]. Sonata Vox Gabrieli / Stjepan Sulek -- [Track 4]. Reflective Mood / Sammy Nestico -- [Track 5]. Anything Goes / [Cole Porter] ; arranged by Al Cobine

Concert recording 2021-11-07a

[Track 1]. La maniere de Shumann /Jean-Michel Defaye -- [Track 2]. Sang till lotta / Jan Sandstrom -- [Track 3]. Concertino in B♭ / Ernst Sachse -- [Track 4]. Nearer my God to thee for 9 celli / James Stevens -- [Track 5]. Ave Maria / Franz Biebl -- [Track 6]. Soundtrack for trombone / Brian Sadler

Concert recording 2018-10-22

[Track 1]. Ballade / Frank Martin -- [Track 2]. Suite for four trombones, op. 82. I. Entrata [Track 3]. II. Lied [Track 4]. III. Dans / Flor Peeters -- [Track 5]. America the beautiful / Samuel Ward arranged by Robert Elkjer -- [Track 6]. Elegy for Mippy II / Leonard Bernstein -- [Track 7]. In memorium / Raymond Premru -- [Track 8]. Anything goes / Cole Porter arranged by Al Cobine -- [Track 9]. Suite for four trombones. I. Moderato maestoso [Track 10]. II. Andantino [Track 11]. III. Choral [Track 12]. IV. Scherzo / Desire Dondeyne -- [Track 13]. That\u27s a plenty / Lew Pollack arranged by Jack Gale

Concert recording 2019-02-07b

[Track 1]. Après un rêve from Trois melodies, op. 7 / Gabriel Fauré -- [Track 2]. The little horses / Aaron Copland -- [Track 3]. Denn es genet den Menschen wie dem Vieh from Four serious songs, op. 121 / Johannes Brahms -- [Track 4]. War song no. 2 / Charles Ives -- [Track 5]. Song to the moon from Rusalka / Antonin Dvořák -- [Track 6]. Prison / Gabriel Fauré -- [Track 7]. O Tod, wie bitter bist du from Four serious songs, op. 121 / Johannes Brahms -- [Track 8]. Dreams / Charles Ives -- [Track 9]. Der Erkönig / Schubert

Concert recording 2019-10-23

[Track 1]. Morgenmusik. I. Massig bewegt [Track 2]. II. Langsame viertel [Track 3]. III. Bewegt / Paul Hindemith -- [Track 4]. Joshua fit de Battle of Jericho / traditional, arranged by Chris Woods -- [Track 5]. Fantasy for trombone / Elizabeth Raum -- [Track 6]. Suite. I. Passepied [Track 7]. II. Arietta [Track 8]. III. March / Johann Adolphe Hesse, ed. William Glover -- [Track 9]. Suite for four trombones. I. Poco maestoso [Track 10]. II. Sarabanda [Track 11]. III. Alla marcia [Track 12]. IV. Spirituale [Track 13]. V. Finale alla fuga / Gordon Jacob -- [Track 14]. Concertino. II. Aria: Andante sostenuto [Track 15]. III. Finale: Allegro giocoso / Lars-Erik Larsson -- [Track 16]. Andante et allegro / Joseph Edouard Barat -- [Track 17]. Horizon of the Aten / Anthony Barfield -- [Track 18]. Round midnight / Thelonious Monk, arranged by Slide Hampton

Genome-wide association study of a nicotine metabolism biomarker in African American smokers:impact of chromosome 19 genetic influences

BACKGROUND AND AIMS: The activity of CYP2A6, the major nicotine-inactivating enzyme, is measurable in smokers using the nicotine metabolite ratio (NMR; 3'hydroxycotinine/cotinine). Due to its role in nicotine clearance, the NMR is associated with smoking behaviours and response to pharmacotherapies. The NMR is highly heritable (~80%), and on average lower in African Americans (AA) versus whites. We previously identified several reduce and loss-of-function CYP2A6 variants common in individuals of African descent. Our current aim was to identify novel genetic influences on the NMR in AA smokers using genome-wide approaches. DESIGN: Genome-wide association study (GWAS). SETTING: Multiple sites within Canada and the United States. PARTICIPANTS: AA smokers from two clinical trials: Pharmacogenetics of Nicotine Addiction Treatment (PNAT)-2 (NCT01314001; n = 504) and Kick-it-at-Swope (KIS)-3 (NCT00666978; n = 450). MEASUREMENTS: Genome-wide SNP genotyping, the NMR (phenotype) and population substructure and NMR covariates. FINDINGS: Meta-analysis revealed three independent chromosome 19 signals (rs12459249, rs111645190 and rs185430475) associated with the NMR. The top overall hit, rs12459249 (P = 1.47e-39; beta = 0.59 per C (versus T) allele, SE = 0.045), located ~9.5 kb 3' of CYP2A6, remained genome-wide significant after controlling for the common (~10% in AA) non-functional CYP2A6*17 allele. In contrast, rs111645190 and rs185430475 were not genome-wide significant when controlling for CYP2A6*17. In total, 96 signals associated with the NMR were identified; many were not found in prior NMR GWASs in individuals of European descent. The top hits were also associated with the NMR in a third cohort of AA (KIS2; n = 480). None of the hits were in UGT or OCT2 genes. CONCLUSIONS: Three independent chromosome 19 signals account for ~20% of the variability in the nicotine metabolite ratio in African American smokers. The hits identified may contribute to inter-ethnic variability in nicotine metabolism, smoking behaviours and tobacco-related disease risk

Cortisol metabolic predictors of response to psychotherapy for symptoms of PTSD in survivors of the World Trade Center attacks on September 11, 2001

BACKGROUND: A proportion of subjects with symptoms of posttraumatic stress disorder (PTSD) are unresponsive to specialized psychotherapy, but a biological basis for this has not been described. To observe whether differences in cortisol or its metabolites predict or correlate with response to therapy for PTSD symptoms, cortisol and its metabolites were measured from urine samples at pre-treatment, at the conclusion of psychotherapy, and at 3-month follow-up. METHODS: 28 survivors of the World Trade Center attack on September 11, 2001 seeking psychological treatment for PTSD symptoms received four sessions of either exposure therapy or supportive counseling, followed by up to 10 sessions of prolonged exposure in a specialized PTSD treatment program at a private hospital serving the New York City metropolitan area. 24-hr mean integrated cortisol excretion was assessed by radioimmunoassay (RIA); urinary free cortisol and metabolites cortisone, 5α–tetrahydrocortisol (5α-THF), 5β–tetrahydrocortisol, and tetrahydrocortisone were assessed by gas chromatography-mass spectrometry (GCMS); and indices of enzyme activities for 5α–and 5β–reductase and for the 11β–hydroxysteroid dehydrogenases were derived from the metabolite and glucocorticoid measures. RESULTS: 5α-reductase activity was significantly lower at pre-treatment among non-responders, whereas there were no significant pre-treatment differences between responders and non-responders in any other hormone or metabolite level. In repeated-measures analyses across the three time points, 5α-reductase activity, as well as 5α-THF and total glucocorticoids, significantly differed between responders and non-responders. For urinary cortisol measured by RIA, there was a significant group × time interaction indicating that, although not different at pre-treatment, urinary cortisol levels declined over time in the non-responder group, such that by follow-up, lowered cortisol significantly distinguished non-responders from responders. Indices of 5α-reductase activity, including 5α-THF and total glucocorticoids, were significantly negatively correlated with avoidance symptom severity at pre-treatment. At follow-up, indices of 5α-reductase activity were significantly negatively correlated with severity of all three PTSD symptom clusters and with total PTSD severity scores. CONCLUSION: Lower 5α–reductase activity is associated with avoidance severity and predicts non-responsiveness to psychological treatment for PTSD symptomatology. Relatively diminished 5α–reductase activity may mark a state of primary vulnerability, perhaps via attenuated peripheral catabolism of cortisol resulting in the suppression of hypothalamic-pituitary-adrenal axis responsiveness. Lower cortisol levels appear later in the progression to chronic, treatment-resistant PTSD

Implicit Bias in Grantmaking, EPIP Webinar

How Does Implicit Bias Influence Philanthropic Effectiveness? How well do you know your subconscious? Why does it matter? Proven science tells us that our conscious commitments to fairness and equality can be undermined by subconscious assumptions we may not even be aware.This interactive session with Jeanné Isler, Field Director at the National Committee for Responsive Philanthropy; Rachel Godsil, Director of Research at the Perception Institute and Crystal Echo Hawk, President & CEO of Echo Hawk Consulting and a member of the Pawnee Nation of Oklahoma, explores the definitions of implicit bias, its effect on all of us as individuals, and its influence on the decisions and trends in our philanthropic institutions

Social support for exercise from pregnancy to postpartum and the potential impact of a mobile application: A randomized control pilot trial in Southern United States

This study compared perceived social support among women of all body mass index (BMI) categories with an attempt to assess the efficacy of the BumptUp® mobile application to improve social support for exercise during pregnancy and postpartum. Thirty-five pregnant women living in Southern United States were included in the sample. The intervention group received access to the BumptUp® mobile application that was designed to promote physical activity during pregnancy and postpartum. The control group received an evidence-based educational brochure. Perceived social support for exercise was assessed at four-time points using the social support and exercise survey. Outcomes were evaluated at 23–25, 35–37 gestational weeks, and 6 and 12 weeks postpartum. Based on their pre-pregnancy weight and height, BMI was computed to categorize participants into lean, overweight, and obese groups. Social support across BMI categories and between control and intervention groups were compared using linear mixed-effect models. Women grouped in the overweight and obese BMI categories reported receiving significantly lower levels of social support for exercise than women in the lean category throughout pregnancy and postpartum during mid-pregnancy, late pregnancy, and at 12 weeks postpartum (p  0.05). Women with a pre-pregnancy BMI of overweight and obese received lower social support for exercise during pregnancy and postpartum. The efficacy of BumptUp® to improve perceived social support for exercise in pregnancy and postpartum was not evident in the results