Ethnicity, socioeconomic status, transfusions and risk of hepatitis B and hepatitis C infection

This study identifies the risk factors for hepatitis B virus (HBV) and hepatitis C virus (HCV) and measures the prevalence of hepatitis B surface antigen (HBsAg) and antibody to hepatitis C (anti-HCV) in the general population of Jakarta. A population-based sample of 985 people aged 15 and above was surveyed. Risk factors were identified through questionnaires and home visits. Serum was analysed for HBsAg, antibody to hepatitis B surface antigen (anti-HBs), anti-HCV, aspartate aminotransferase (AST) and alanine aminotransferase (ALT). The seroprevalence was: 4.0% (39/985) for HBsAg, 17.2% (170/985) for anti-HBs, and 3.9% (38/985) for anti-HCV. The risk factors for hepatitis B and hepatitis C infection had little in common. Low socioeconomic status was a strong risk factor for HBsAg (adjusted odds ratio (OR) 18.09; 95% confidence interval (CI) 2.35–139.50). In addition, the Chinese group has 2.97 higher risk of having HBV infection compared with the Malayan ethnic group (adjusted OR 2.97; 95% CI 1.22–7.83). There was moderate positive trend between family size and risk of HBsAg positivity ( P = 0.130). Age over 50 (adjusted OR 14.72; 95% CI 4.35–49.89) and history of transfusion were significant risk factors for hepatitis C (adjusted OR 3.03; 95% CI 1.25–7.33). Hepatitis B and hepatitis C infections have different risk factors in Jakarta, a high risk in population for both diseases. Hepatitis B transmission is associated with low socioeconomic status, Chinese ethnic group and large family size, while hepatitis C is associated with an older age and a history of transfusions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72591/1/j.1440-1746.1997.tb00365.x.pd

Brine reject dilution with treated wastewater for indirect desalination

The forward osmosis (FO) process was suggested as a pretreatment to a multi-stage flashing (MSF) plant to reduce the environmental impact of brine discharge and the chemicals used. Yet, there is no study investigating the performance of the FO process pretreatment to the MSF plant using tertiary sewage effluent (TSE) as a feed solution. Combining MSF brine with the TSE generates a considerable permeation flux, reducing the membrane area and capital cost. This study evaluated the performance of the FO process for indirect desalination of the MSF brine, considering membrane fouling, cleaning, required membrane area and the specific power consumption. The FO process used a thin-film composite (TFC) membrane to dilute the brine reject from the MSF plant by the TSE and hence converting waste solutions into a feasible water resource. A considerable high water flux (±35 L/m2h) was generated and slightly decreased throughout each experiment's 4 cycles. An enhancement in the water permeability was observed in the FO tests with a prefiltration of the brine reject and the wastewater with 20 μm and an osmotic backwash cleaning of the used membrane. The prefiltration of the draw and feed solutions was effective in minimizing the impact of fouling. Maximum power consumption of 0.007 kWh/m³ was consumed in the forward osmosis process without prefiltration and decreased to 0.006 kWh/m³ in the FO process. The proposed FO system successfully diluted the brine reject’ divalent ions, reducing their concentration to 43% in some cases. Depending on the FO membrane orientation, the TSE feed solution resulted in a 276%–473% reduction in the number of FO elements required in the FO process compared to the seawater feed solution.This publication was supported by NPRP grant 10-0117-170176 from the Qatar National Research Fund (a member of Qatar Foundation ).Scopu

Soluble tumor necrosis factor receptor 1 and 2 predict outcomes in advanced chronic kidney disease : a prospective cohort study

Background : Soluble tumor necrosis factor receptors 1 (sTNFR1) and 2 (sTNFR2) have been associated to progression of renal failure, end stage renal disease and mortality in early stages of chronic kidney disease (CKD), mostly in the context of diabetic nephropathy. The predictive value of these markers in advanced stages of CKD irrespective of the specific causes of kidney disease has not yet been defined. In this study, the relationship between sTNFR1 and sTNFR2 and the risk for adverse cardiovascular events (CVE) and all-cause mortality was investigated in a population with CKD stage 4-5, not yet on dialysis, to minimize the confounding by renal function. Patients and methods : In 131 patients, CKD stage 4-5, sTNFR1, sTNFR2 were analysed for their association to a composite endpoint of all-cause mortality or first non-fatal CVE by univariate and multivariate Cox proportional hazards models. In the multivariate models, age, gender, CRP, eGFR and significant comorbidities were included as covariates. Results : During a median follow-up of 33 months, 40 events (30.5%) occurred of which 29 deaths (22.1%) and 11 (8.4%) first non-fatal CVE. In univariate analysis, the hazard ratios (HR) of sTNFR1 and sTNFR2 for negative outcome were 1.49 (95% confidence interval (CI): 1.28-1.75) and 1.13 (95% CI: 1.06-1.20) respectively. After adjustment for clinical covariables (age, CRP, diabetes and a history of cardiovascular disease) both sTNFRs remained independently associated to outcomes (HR: sTNFR1: 1.51, 95% CI: 1.30-1.77; sTNFR2: 1.13, 95% CI: 1.06-1.20). A subanalysis of the non-diabetic patients in the study population confirmed these findings, especially for sTNFR1. Conclusion : sTNFR1 and sTNFR2 are independently associated to all-cause mortality or an increased risk for cardiovascular events in advanced CKD irrespective of the cause of kidney disease

Solid deuterium surface degradation at ultracold neutron sources

Solid deuterium (sD_2) is used as an efficient converter to produce ultracold neutrons (UCN). It is known that the sD_2 must be sufficiently cold, of high purity and mostly in its ortho-state in order to guarantee long lifetimes of UCN in the solid from which they are extracted into vacuum. Also the UCN transparency of the bulk sD_2 material must be high because crystal inhomogeneities limit the mean free path for elastic scattering and reduce the extraction efficiency. Observations at the UCN sources at Paul Scherrer Institute and at Los Alamos National Laboratory consistently show a decrease of the UCN yield with time of operation after initial preparation or later treatment (`conditioning') of the sD_2. We show that, in addition to the quality of the bulk sD_2, the quality of its surface is essential. Our observations and simulations support the view that the surface is deteriorating due to a build-up of D_2 frost-layers under pulsed operation which leads to strong albedo reflections of UCN and subsequent loss. We report results of UCN yield measurements, temperature and pressure behavior of deuterium during source operation and conditioning, and UCN transport simulations. This, together with optical observations of sD_2 frost formation on initially transparent sD_2 in offline studies with pulsed heat input at the North Carolina State University UCN source results in a consistent description of the UCN yield decrease.Comment: 15 pages, 22 figures, accepted by EPJ-

First Measurement of the Neutron β\beta-Asymmetry with Ultracold Neutrons

We report the first measurement of angular correlation parameters in neutron $\beta$-decay using polarized ultracold neutrons (UCN). We utilize UCN with energies below about 200 neV, which we guide and store for $\sim 30$ s in a Cu decay volume. The $\vec{\mu}_n \cdot \vec{B}$ potential of a static 7 T field external to the decay volume provides a 420 neV potential energy barrier to the spin state parallel to the field, polarizing the UCN before they pass through an adiabatic fast passage (AFP) spin-flipper and enter a decay volume, situated within a 1 T, $2 \times 2\pi$ superconducting solenoidal spectrometer. We determine a value for the $\beta$-asymmetry parameter $A_0$, proportional to the angular correlation between the neutron polarization and the electron momentum, of $A_0 = -0.1138 \pm 0.0051$.Comment: 4 pages, 2 figures, 1 table, submitted to Phys. Rev. Let

Final results for the neutron β-asymmetry parameter A₀ from the UCNA experiment

The UCNA experiment was designed to measure the neutron β-asymmetry parameter A0 using polarized ultracold neutrons (UCN). UCN produced via downscattering in solid deuterium were polarized via transport through a 7 T magnetic field, and then directed to a 1 T solenoidal electron spectrometer, where the decay electrons were detected in electron detector packages located on the two ends of the spectrometer. A value for A0 was then extracted from the asymmetry in the numbers of counts in the two detector packages. We summarize all of the results from the UCNA experiment, obtained during run periods in 2007, 2008–2009, 2010, and 2011–2013, which ultimately culminated in a 0.67% precision result for A₀