244 research outputs found
Studies of Acute Intestinal Obstruction. I. Different Types of Obstruction Produced under Local Anesthesia
11 p. Reprinted from: Archives of Internal Medicine, Vol. 34, No. 1, July 1924
Guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen of Saccharomyces cerevisiae
Current models for nucleotide sugar use in the Golgi apparatus predict a critical role for the lumenal nucleoside diphosphatase. After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol. To test this model, we cloned the gene for the S. cerevisiae guanosine diphosphatase and constructed a null mutation. This mutation should reduce the concentrations of GDP-mannose and GMP and increase the concentration of GDP in the Golgi lumen. The alterations should in turn decrease mannosylation of proteins and lipids in this compartment. In fact, we found a partial block in O- and N-glycosylation of proteins such as chitinase and carboxypeptidase Y and underglycosylation of invertase. In addition, mannosylinositolphosphorylceramide levels were drastically reduced
A Mass Bound for Spherically Symmetric Black Hole Spacetimes
Requiring that the matter fields are subject to the dominant energy
condition, we establish the lower bound for the
total mass of a static, spherically symmetric black hole spacetime. ( and denote the area and the surface gravity of the horizon,
respectively.) Together with the fact that the Komar integral provides a simple
relation between and the strong energy condition,
this enables us to prove that the Schwarzschild metric represents the only
static, spherically symmetric black hole solution of a selfgravitating matter
model satisfying the dominant, but violating the strong energy condition for
the timelike Killing field at every point, that is, .
Applying this result to scalar fields, we recover the fact that the only black
hole configuration of the spherically symmetric Einstein-Higgs model with
arbitrary non-negative potential is the Schwarzschild spacetime with constant
Higgs field. In the presence of electromagnetic fields, we also derive a
stronger bound for the total mass, involving the electromagnetic potentials and
charges. Again, this estimate provides a simple tool to prove a ``no-hair''
theorem for matter fields violating the strong energy condition.Comment: 16 pages, LATEX, no figure
An Explanation for the Observed Weak Size Evolution of Disk Galaxies
Surveys of distant galaxies with the Hubble Space Telescope and from the
ground have shown that there is only mild evolution in the relationship between
radial size and stellar mass for galactic disks from z~1 to the present day.
Using a sample of nearby disk-dominated galaxies from the Sloan Digital Sky
Survey (SDSS), and high redshift data from the GEMS (Galaxy Evolution from
Morphology and SEDs) survey, we investigate whether this result is consistent
with theoretical expectations within the hierarchical paradigm of structure
formation. The relationship between virial radius and mass for dark matter
halos in the LCDM model evolves by about a factor of two over this interval.
However, N-body simulations have shown that halos of a given mass have less
centrally concentrated mass profiles at high redshift. When we compute the
expected disk size-stellar mass distribution, accounting for this evolution in
the internal structure of dark matter halos and the adiabatic contraction of
the dark matter by the self-gravity of the collapsing baryons, we find that the
predicted evolution in the mean size at fixed stellar mass since z~1 is about
15-20 percent, in good agreement with the observational constraints from GEMS.
At redshift z~2, the model predicts that disks at fixed stellar mass were on
average only 60% as large as they are today. Similarly, we predict that the
rotation velocity at a given stellar mass (essentially the zero-point of the
Tully-Fisher relation) is only about 10 percent larger at z~1 (20 percent at
z~2) than at the present day.Comment: 13 pages, 6 figures, accepted for publication in ApJ. Revised in
response to referee's comments to improve clariry. Results are unchange
GEMS: The Size Evolution of Disk Galaxies
We combine HST imaging from the GEMS survey with photometric redshifts from
COMBO-17 to explore the evolution of disk-dominated galaxies since z<1.1. The
sample is comprised of all GEMS galaxies with Sersic indices n<2.5, derived
from fits to the galaxy images. We account fully for selection effects through
careful analysis of image simulations; we are limited by the depth of the
redshift and HST data to the study of galaxies with absolute magnitudes
M(V)10. We find strong evolution in
the magnitude-size scaling relation for galaxies with M(V)<-20, corresponding
to a brightening of 1 mag per sqarcsec in rest-frame V-band by z=1. Yet, disks
at a given absolute magnitude are bluer and have lower stellar mass-to-light
ratios at z=1 than at the present day. As a result, our findings indicate weak
or no evolution in the relation between stellar mass and effective disk size
for galaxies with log(M)>10 over the same time interval. This is strongly
inconsistent with the most naive theoretical expectation, in which disk size
scales in proportion to the halo virial radius, which would predict that disks
are a factor of two denser at fixed mass at z=1. The lack of evolution in the
stellar mass-size relation is consistent with an ``inside-out'' growth of
galaxy disks on average (galaxies increasing in size as they grow more
massive), although we cannot rule out more complex evolutionary scenarios.Comment: 22 pages, 16 figures, submitted to Ap
Identification and validation of oncologic miRNA biomarkers for Luminal A-like breast cancer
Introduction: Breast cancer is a common disease with distinct tumor subtypes phenotypically characterized by ER and HER2/neu receptor status. MiRNAs play regulatory roles in tumor initiation and progression, and altered miRNA expression has been demonstrated in a variety of cancer states presenting the potential for exploitation as cancer biomarkers. Blood provides an excellent medium for biomarker discovery. This study investigated systemic miRNAs differentially expressed in Luminal A-like (ER+PR+HER2/neu-) breast cancer and their effectiveness as oncologic biomarkers in the clinical setting. Methods: Blood samples were prospectively collected from patients with Luminal A-like breast cancer (n=54) and controls (n=56). RNA was extracted, reverse transcribed and subjected to microarray analysis (n=10 Luminal A-like; n=10 Control). Differentially expressed miRNAs were identified by artificial neural network (ANN) data-mining algorithms. Expression of specific miRNAs was validated by RQ-PCR (n=44 Luminal A; n=46 Control) and potential relationships between circulating miRNA levels and clinicopathological features of breast cancer were investigated. Results: Microarray analysis identified 76 differentially expressed miRNAs. ANN revealed 10 miRNAs for further analysis ( miR-19b, miR-29a, miR-93, miR-181a, miR-182, miR-223, miR-301a, miR-423-5p, miR-486-5 and miR-652 ). The biomarker potential of 4 miRNAs ( miR-29a, miR-181a , miR-223 and miR-652 ) was confirmed by RQ-PCR, with significantly reduced expression in blood of women with Luminal A-like breast tumors compared to healthy controls (p=0.001, 0.004, 0.009 and 0.004 respectively). Binary logistic regression confirmed that combination of 3 of these miRNAs ( miR-29a, miR-181a and miR-652 ) could reliably differentiate between cancers and controls with an AUC of 0.80. Conclusion: This study provides insight into the underlying molecular portrait of Luminal A-like breast cancer subtype. From an initial 76 miRNAs, 4 were validated with altered expression in the blood of women with Luminal A-like breast cancer. The expression profiles of these 3 miRNAs, in combination with mammography, has potential to facilitate accurate subtype- specific breast tumor detection
Co-ordination between Rashba spin-orbital interaction and space charge effect and enhanced spin injection into semiconductors
We consider the effect of the Rashba spin-orbital interaction and space
charge in a ferromagnet-insulator/semiconductor/insulator-ferromagnet junction
where the spin current is severely affected by the doping, band structure and
charge screening in the semiconductor. In diffusion region, if the the
resistance of the tunneling barriers is comparable to the semiconductor
resistance, the magnetoresistance of this junction can be greatly enhanced
under appropriate doping by the co-ordination between the Rashba effect and
screened Coulomb interaction in the nonequilibrium transport processes within
Hartree approximation.Comment: 4 pages, 3 figure
A Study of the 't Hooft Model with the Overlap Dirac Operator
We present the results of an exploratory numerical study of two dimensional
QCD with overlap fermions. We have performed extensive simulations for U(N_c)
and SU(N_c) color groups with N_c=2, 3, 4 and coupling constants chosen to
satisfy the 't Hooft condition g^2 N_c =const=4/3. We have computed the meson
spectrum and decay constants, the topological susceptibility and the chiral
condensate. For U(N_c) gauge groups, our results indicate that the
Witten-Veneziano relation is satisfied within our statistical errors and that
the chiral condensate for N_f=1 is compatible with a non-zero value. Our
results exhibit universality in N_c and confirm once more the excellent chiral
properties of the overlap-Dirac operator.Comment: 18 pages, 4 figure
- …