Interstellar H-Alpha Line Profiles toward HD 93521 and the Lockman Window

We have used the Wisconsin H-Alpha Mapper (WHAM) facility to measure the interstellar H-Alpha emission toward the high Galactic latitude O star HD 93521 (l = 183.1, b = +62.2). Three emission components were detected having radial velocities of -10 km s^{-1}, -51 km s^{-1}, and -90 km s^{-1} with respect to the local standard of rest (LSR) and H-Alpha intensities of 0.20 R, 0.15 R, and 0.023 R, respectively, corresponding to emission measures of 0.55 cm^{-6} pc, 0.42 cm^{-6} pc, and 0.06 cm^{-6} pc. We have also detected an H-Alpha emission component at -1 km s^{-1} (LSR) with an intensity of 0.20 R (0.55 cm^{-6} pc) toward the direction l = 148.5, b = +53.0, which lies in the region of exceptionally low H I column density known as the Lockman Window. In addition, we studied the direction l = 163.5, b = +53.5. Upper limits on the possible intensity of Galactic emission toward this direction are 0.11 R at the LSR and 0.06 R at -50 km s^{-1}. We also detected and characterized twelve faint (~0.03-0.15 R), unidentified atmospheric lines present in WHAM H-Alpha spectra. Lastly, we have used WHAM to obtain [O I] 6300 spectra along the line of sight toward HD 93521. We place an upper limit of 0.060 R on the [O I] intensity of the -51 km s^{-1} component. If the temperature of the gas is 10,000 K within the H-Alpha emitting region, the hydrogen ionization fraction n(H+)/n(H_total) > 0.6.Comment: 23 pages, 4 figures. Acccepted for publication in the 1 Feb issue of The Astronomical Journa

Photoionization of Galactic Halo Gas by Old Supernova Remnants

We present new calculations on the contribution from cooling hot gas to the photoionization of warm ionized gas in the Galaxy. We show that hot gas in cooling supernova remnants (SNRs) is an important source of photoionization, particularly for gas in the halo. We find that in many regions at high latitude this source is adequate to account for the observed ionization so there is no need to find ways to transport stellar photons from the disk. The flux from cooling SNRs sets a floor on the ionization along any line of sight. Our model flux is also shown to be consistent with the diffuse soft X-ray background and with soft X-ray observations of external galaxies. We consider the ionization of the clouds observed towards the halo star HD 93521, for which there are no O stars close to the line of sight. We show that the observed ionization can be explained successfully by our model EUV/soft X-ray flux from cooling hot gas. In particular, we can match the H alpha intensity, the S++/S+ ratio, and the C+* column. From observations of the ratios of columns of C+* and either S+ or H0, we are able to estimate the thermal pressure in the clouds. The slow clouds require high (~10^4 cm^-3 K) thermal pressures to match the N(C+*)/N(S+) ratio. Additional heating sources are required for the slow clouds to maintain their ~7000 K temperatures at these pressures, as found by Reynolds, Hausen & Tufte (1999).Comment: AASTeX 5.01; 34 pages, 2 figures; submitted to Astrophysical Journa

On the classification of Kahler-Ricci solitons on Gorenstein del Pezzo surfaces

We give a classification of all pairs (X,v) of Gorenstein del Pezzo surfaces X and vector fields v which are K-stable in the sense of Berman-Nystrom and therefore are expected to admit a Kahler-Ricci solition. Moreover, we provide some new examples of Fano threefolds admitting a Kahler-Ricci soliton.Comment: 21 pages, ancillary files containing calculations in SageMath; minor correction

Numerical Model of a Variable-Combined-Cycle Engine for Dual Subsonic and Supersonic Cruise

Efficient high speed propulsion requires exploiting the cooling capability of the cryogenic fuel in the propulsion cycle. This paper presents the numerical model of a combined cycle engine while in air turbo-rocket configuration. Specific models of the various heat exchanger modules and the turbomachinery elements were developed to represent the physical behavior at off-design operation. The dynamic nature of the model allows the introduction of the engine control logic that limits the operation of certain subcomponents and extends the overall engine operational envelope. The specific impulse and uninstalled thrust are detailed while flying a determined trajectory between Mach 2.5 and 5 for varying throttling levels throughout the operational envelope

Gaps in detailed knowledge of human papillomavirus (HPV) and the HPV vaccine among medical students in Scotland

<p>Background: A vaccination programme targeted against human papillomavirus (HPV) types16 and 18 was introduced in the UK in 2008, with the aim of decreasing incidence of cervical disease. Vaccine roll out to 12–13 year old girls with a catch-up programme for girls aged up to 17 years and 364 days was accompanied by a very comprehensive public health information (PHI) campaign which described the role of HPV in the development of cervical cancer.</p> <p>Methods: A brief questionnaire, designed to assess acquisition of knowledge of HPV infection and its association to cervical cancer, was administered to two different cohorts of male and female 1st year medical students (school leavers: 83% in age range 17–20) at a UK university. The study was timed so that the first survey in 2008 immediately followed a summer's intensive PHI campaign and very shortly after vaccine roll-out (150 students). The second survey was exactly one year later over which time there was a sustained PHI campaign (213 students).</p> <p>Results: We addressed three research questions: knowledge about three specific details of HPV infection that could be acquired from PHI, whether length of the PHI campaign and/or vaccination of females had any bearing on HPV knowledge, and knowledge differences between men and women regarding HPV. No female student in the 2008 cohort had completed the three-dose vaccine schedule compared to 58.4% of female students in 2009. Overall, participants’ knowledge regarding the sexually transmitted nature of HPV and its association with cervical cancer was high in both year groups. However, in both years, less than 50% of students correctly identified that HPV causes over 90% of cases of cervical cancer. Males gave fewer correct answers for these two details in 2009. In 2008 only around 50% of students recognised that the current vaccine protects against a limited subset of cervical cancer-causing HPV sub-types, although there was a significant increase in correct response among female students in the 2009 cohort compared to the 2008 cohort.</p> <p>onclusions: This study highlights a lack of understanding regarding the extent of protection against cervical cancer conferred by the HPV vaccine, even among an educated population in the UK who could have a vested interest in acquiring such knowledge. The intensive PHI campaign accompanying the first year of HPV vaccination seemed to have little effect on knowledge over time. This is one of the first studies to assess detailed knowledge of HPV in both males and females. There is scope for continued improvements to PHI regarding the link between HPV infection and cervical cancer.</p&gt

A Single-Arm, Proof-Of-Concept Trial of Lopimune (Lopinavir/Ritonavir) as a Treatment for HPV-Related Pre-Invasive Cervical Disease

BACKGROUND: Cervical cancer is the most common female malignancy in the developing nations and the third most common cancer in women globally. An effective, inexpensive and self-applied topical treatment would be an ideal solution for treatment of screen-detected, pre-invasive cervical disease in low resource settings. METHODS: Between 01/03/2013 and 01/08/2013, women attending Kenyatta National Hospital's Family Planning and Gynaecology Outpatients clinics were tested for HIV, HPV (Cervista®) and liquid based cervical cytology (LBC -ThinPrep®). HIV negative women diagnosed as high-risk HPV positive with high grade squamous intraepithelial lesions (HSIL) were examined by colposcopy and given a 2 week course of 1 capsule of Lopimune (CIPLA) twice daily, to be self-applied as a vaginal pessary. Colposcopy, HPV testing and LBC were repeated at 4 and 12 weeks post-start of treatment with a final punch biopsy at 3 months for histology. Primary outcome measures were acceptability of treatment with efficacy as a secondary consideration. RESULTS: A total of 23 women with HSIL were treated with Lopimune during which time no adverse reactions were reported. A maximum concentration of 10 ng/ml of lopinavir was detected in patient plasma 1 week after starting treatment. HPV was no longer detected in 12/23 (52.2%, 95%CI: 30.6-73.2%). Post-treatment cytology at 12 weeks on women with HSIL, showed 14/22 (63.6%, 95%CI: 40.6-82.8%) had no dysplasia and 4/22 (18.2%, 95%CI: 9.9-65.1%) were now low grade demonstrating a combined positive response in 81.8% of women of which 77.8% was confirmed by histology. These data are supported by colposcopic images, which show regression of cervical lesions. CONCLUSIONS: These results demonstrate the potential of Lopimune as a self-applied therapy for HPV infection and related cervical lesions. Since there were no serious adverse events or detectable post-treatment morbidity, this study indicates that further trials are clearly justified to define optimal regimes and the overall benefit of this therapy. TRIAL REGISTRATION: ISRCTN Registry 48776874

Ensaio regional de linhagens de arroz irrigado do Programa de Melhoramento Genético da Embrapa no RS - safra 2008/09.

O Ensaio Regional de linhagens de arroz irrigado visa selecionar genótipos que apresentem alta adaptabilidade e estabilidade aos diversos ambientes em que são cultivadas e que expressem elevado rendimento de grãos, associado à características agronômicas, industriais e culinárias adequadas. Este experimento teve como objetivo avaliar linhagens do programa da Embrapa no Ensaio Regional de Rendimento

Desempenho de linhagens elites de arroz irrigado de ciclo precoce do Programa de Melhoramento Genético da Embrapa em ensaios VCU no RS - safra 2008/09.

O objetivo deste trabalho foi avaliar o desempenho em rendimento de grãos e características agronômicas de interesse das linhagens de ciclo precoce geradas pelo programa de melhoramento genético da Embrapa, em diferentes regiões orizícolas do Rio Grande do Sul, para verificar a possibilidade de indicação de novas cultivares