130 research outputs found
Free cashflow and firm performance: Evidence from sectoral levels for Vietnamese listed firms
Using data of listed firms on Hochiminh Stock Exchange, the study examines the impact of free cashflowson firm performance of manufacture, trade and real estates sectors. The findingsconsistently show that free cashflowshave a positive effect on firm performance for all sectors. However, the impact of free cashflows on firm performanceis different between firms with and without investment opportunities. This shows the relevance of Jensen\u27s free-cashflows theory (1986) to listed Vietnamese firms at thesectoral level
Determinants of Corporate Disclosure in Financial Statements: Evidence from Vietnamese Listed Firms
Using data of listed firms on Hochiminh Stock Exchange, the study examines determinants of corporate disclosure in financial statements. In line with the literature, the findingsshow that firm size, the use of financial leverage and the presence of supervision board have a positive influence on corporate disclosure. Furthermore, auditing firm (whether a Big4 or not) also plays an important role in the degree of information disclosure by firms.Contradicting to the literature, however state ownership and the proportion of non-executive members in director board show a negative relation to corporate disclosure level. These counter factscanbe explained by real situations of Vietnam over the studied period. Finally, the concurrent role between chair of director board and managing director reduces corporate disclosure degree, as predicted by the agency theory
The Causality Relationship between Hnx Index and Stock Trading Volume in Hanoi Stock Exchange
This paper examines the casual relations between the market return and trading volume for the Ha Noi Stock Exchange during the period from May 3th , 2013 to March 2rd, 2016. This paper uses Granger test and the results showed that the change of the volume of transactions that affect the change of HNX-Index. On the basis of this conclusion, we shall determine the degree of influence of the change in trading volume with HNX-Index by means of regression analysis
Hubble Space Telescope Imaging of the CFRS and LDSS Redshift Surveys---III. Field elliptical galaxies at 0.2 < z < 1.0
Surface photometry has been performed on a sample of 46 field elliptical
galaxies. These galaxies are described well by a deVaucouleurs R^{1/4} profile.
The sample was selected from the combined Canada-France and LDSS redshift
surveys and spans the range 0.20 < z < 1.00. The relationship between galaxy
half-light radius and luminosity evolves such that a galaxy of a given size is
more luminous by Delta M_B=-0.97 \pm 0.14 mag at z=0.92 and the mean rest-frame
color shifts blueward by Delta (U-V) =-0.68 \pm 0.11 at z=0.92 relative to the
local cluster relations. Approximately 1/3 of these elliptical galaxies exhibit
[OII] 3727 emission lines with equivalent widths > 15 angstroms indicating
ongoing star formation. Estimated star-formation rates imply that \le 5% of the
stellar mass in the elliptical galaxy population has been formed since z=1. We
see no evidence for a decline in the space density of early-type galaxies with
look-back time. The statistics and a comparison with local
luminosity functions are both consistent with the view that the population of
massive early-type galaxies was largely in place by z~1. This implies that
merging is not required since that time to produce the present-day space
density of elliptical galaxies.Comment: 21 pages plus 8 figures plus 5 tables. Accepted by Astrophysical
Journa
Zotiraciclib (TG02) for newly diagnosed glioblastoma in the elderly or for recurrent glioblastoma:The EORTC 1608 STEAM trial
Background: Zotiraciclib (TG02) is an oral multi-cyclin dependent kinase (CDK) inhibitor thought to inhibit tumor growth via CDK-9-dependent depletion of survival proteins such as c-MYC and MCL-1 which are frequently overexpressed in glioblastoma. Methods: EORTC 1608 (NCT03224104) (STEAM) had a three parallel group (A,B,C) phase Ib, open-label, non-randomized, multicenter design in IDH wild-type newly diagnosed glioblastoma or anaplastic astrocytoma. Groups A and B explored the maximum tolerated dose (MTD) of TG02 in elderly patients, in combination with hypofractionated radiotherapy alone (group A) or temozolomide alone (group B), according to O6-methylguanine DNA methyltransferase promoter methylation status determined centrally. Group C explored single agent activity of TG02 at first relapse after temozolomide chemoradiotherapy with a primary endpoint of progression-free survival at 6 months (PFS-6). Tumor expression of CDK-9, c-MYC and MCL-1 was determined by immunohistochemistry.Results: The MTD was 150 mg twice weekly in combination with radiotherapy alone (group A) or temozolomide alone (group B). Two dose-limiting toxicities were observed at 150 mg: one in group A (grade 3 seizure), one in group B (multiple grade 1 events). Main toxicities included neutropenia, gastrointestinal disorders and hepatotoxicity. PFS-6 in group C was 6.7%. CDK-9, c-MYC and MCL-1 were confirmed to be expressed and their expression was moderately cross-correlated. High protein levels of MCL-1 were associated with inferior survival. Conclusions: TG02 exhibits overlapping toxicity with alkylating agents and low single agent clinical activity in recurrent glioblastoma. The role of CDK-9 and its down-stream effectors as prognostic factors and therapeutic targets in glioblastoma warrants further study.</p
Zotiraciclib (TG02) for newly diagnosed glioblastoma in the elderly or for recurrent glioblastoma: The EORTC 1608 STEAM trial
BACKGROUND
Zotiraciclib (TG02) is an oral multi-cyclin dependent kinase (CDK) inhibitor thought to inhibit tumor growth via CDK-9-dependent depletion of survival proteins such as c-MYC and MCL-1 which are frequently overexpressed in glioblastoma.
METHODS
EORTC 1608 (NCT03224104) (STEAM) had a three parallel group (A,B,C) phase Ib, open-label, non-randomized, multicenter design in IDH wild-type newly diagnosed glioblastoma or anaplastic astrocytoma. Groups A and B explored the maximum tolerated dose (MTD) of TG02 in elderly patients, in combination with hypofractionated radiotherapy alone (group A) or temozolomide alone (group B), according to O-methylguanine DNA methyltransferase promoter methylation status determined centrally. Group C explored single agent activity of TG02 at first relapse after temozolomide chemoradiotherapy with a primary endpoint of progression-free survival at 6 months (PFS-6). Tumor expression of CDK-9, c-MYC and MCL-1 was determined by immunohistochemistry.
RESULTS
The MTD was 150 mg twice weekly in combination with radiotherapy alone (group A) or temozolomide alone (group B). Two dose-limiting toxicities were observed at 150 mg: one in group A (grade 3 seizure), one in group B (multiple grade 1 events). Main toxicities included neutropenia, gastrointestinal disorders and hepatotoxicity. PFS-6 in group C was 6.7%. CDK-9, c-MYC and MCL-1 were confirmed to be expressed and their expression was moderately cross-correlated. High protein levels of MCL-1 were associated with inferior survival.
CONCLUSIONS
TG02 exhibits overlapping toxicity with alkylating agents and low single agent clinical activity in recurrent glioblastoma. The role of CDK-9 and its down-stream effectors as prognostic factors and therapeutic targets in glioblastoma warrants further study
Zotiraciclib (TG02) for newly diagnosed glioblastoma in the elderly or for recurrent glioblastoma:The EORTC 1608 STEAM trial
Background: Zotiraciclib (TG02) is an oral multi-cyclin dependent kinase (CDK) inhibitor thought to inhibit tumor growth via CDK-9-dependent depletion of survival proteins such as c-MYC and MCL-1 which are frequently overexpressed in glioblastoma. Methods: EORTC 1608 (NCT03224104) (STEAM) had a three parallel group (A,B,C) phase Ib, open-label, non-randomized, multicenter design in IDH wild-type newly diagnosed glioblastoma or anaplastic astrocytoma. Groups A and B explored the maximum tolerated dose (MTD) of TG02 in elderly patients, in combination with hypofractionated radiotherapy alone (group A) or temozolomide alone (group B), according to O6-methylguanine DNA methyltransferase promoter methylation status determined centrally. Group C explored single agent activity of TG02 at first relapse after temozolomide chemoradiotherapy with a primary endpoint of progression-free survival at 6 months (PFS-6). Tumor expression of CDK-9, c-MYC and MCL-1 was determined by immunohistochemistry.Results: The MTD was 150 mg twice weekly in combination with radiotherapy alone (group A) or temozolomide alone (group B). Two dose-limiting toxicities were observed at 150 mg: one in group A (grade 3 seizure), one in group B (multiple grade 1 events). Main toxicities included neutropenia, gastrointestinal disorders and hepatotoxicity. PFS-6 in group C was 6.7%. CDK-9, c-MYC and MCL-1 were confirmed to be expressed and their expression was moderately cross-correlated. High protein levels of MCL-1 were associated with inferior survival. Conclusions: TG02 exhibits overlapping toxicity with alkylating agents and low single agent clinical activity in recurrent glioblastoma. The role of CDK-9 and its down-stream effectors as prognostic factors and therapeutic targets in glioblastoma warrants further study.</p
Generation of atom-photon entangled states in atomic Bose-Einstein condensate via electromagnetically induced transparency
In this paper, we present a method to generate continuous-variable-type
entangled states between photons and atoms in atomic Bose-Einstein condensate
(BEC). The proposed method involves an atomic BEC with three internal states, a
weak quantized probe laser and a strong classical coupling laser, which form a
three-level Lambda-shaped BEC system. We consider a situation where the BEC is
in electromagnetically induced transparency (EIT) with the coupling laser being
much stronger than the probe laser. In this case, the upper and intermediate
levels are unpopulated, so that their adiabatic elimination enables an
effective two-mode model involving only the atomic field at the lowest internal
level and the quantized probe laser field. Atom-photon quantum entanglement is
created through laser-atom and inter-atomic interactions, and two-photon
detuning. We show how to generate atom-photon entangled coherent states and
entangled states between photon (atom) coherent states and atom-(photon-)
macroscopic quantum superposition (MQS) states, and between photon-MQS and
atom-MQS states.Comment: 9 pages, 1 figur
The Cerenkov effect revisited: from swimming ducks to zero modes in gravitational analogs
We present an interdisciplinary review of the generalized Cerenkov emission
of radiation from uniformly moving sources in the different contexts of
classical electromagnetism, superfluid hydrodynamics, and classical
hydrodynamics. The details of each specific physical systems enter our theory
via the dispersion law of the excitations. A geometrical recipe to obtain the
emission patterns in both real and wavevector space from the geometrical shape
of the dispersion law is discussed and applied to a number of cases of current
experimental interest. Some consequences of these emission processes onto the
stability of condensed-matter analogs of gravitational systems are finally
illustrated.Comment: Lecture Notes at the IX SIGRAV School on "Analogue Gravity" in Como,
Italy from May 16th-21th, 201
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