16 research outputs found
Particle Moment Canting in CoFe2O4 Nanoparticles
Polarization-analyzed small-angle neutron scattering methods are used to determine the spin morphology in high crystalline anisotropy, 11 nm diameter CoFe2O4 nanoparticle assemblies with randomly oriented easy axes. In moderate to high magnetic fields, the nanoparticles adopt a uniformly canted structure, rather than forming domains, shells, or other arrangements. The observed canting angles agree quantitatively with those predicted from an energy model dominated by Zeeman and anisotropy competition, with implications for the technological use of such nanoparticles
Genetic effects on gene expression across human tissues
Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression levels across individuals and diverse tissues of the human body, many of which are not easily accessible. Here we describe genetic effects on gene expression levels across 44 human tissues. We find that local genetic variation affects gene expression levels for the majority of genes, and we further identify inter-chromosomal genetic effects for 93 genes and 112 loci. On the basis of the identified genetic effects, we characterize patterns of tissue specificity, compare local and distal effects, and evaluate the functional properties of the genetic effects. We also demonstrate that multi-tissue, multi-individual data can be used to identify genes and pathways affected by human disease-associated variation, enabling a mechanistic interpretation of gene regulation and the genetic basis of diseas
Genetic effects on gene expression across human tissues
Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression levels across individuals and diverse tissues of the human body, many of which are not easily accessible. Here we describe genetic effects on gene expression levels across 44 human tissues. We find that local genetic variation affects gene expression levels for the majority of genes, and we further identify inter-chromosomal genetic effects for 93 genes and 112 loci. On the basis of the identified genetic effects, we characterize patterns of tissue specificity, compare local and distal effects, and evaluate the functional properties of the genetic effects. We also demonstrate that multi-tissue, multi-individual data can be used to identify genes and pathways affected by human disease-associated variation, enabling a mechanistic interpretation of gene regulation and the genetic basis of disease
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Bifurcation of nanoscale thermolubric friction behavior for sliding on MoS2
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Friction Anisotropy of MoS2: Effect of Tip-Sample Contact Quality.
Atomic-scale friction measured for a single asperity sliding on 2D materials depend on the direction of scanning relative to the material's crystal lattice. Here, nanoscale friction anisotropy of wrinkle-free bulk and monolayer MoS2 is characterized using atomic force microscopy and molecular dynamics simulations. Both techniques show 180° periodicity (2-fold symmetry) of atomic-lattice stick-slip friction vs. the tip's scanning direction with respect to the MoS2 surface. The 60° periodicity (6-fold symmetry) expected from the MoS2 surface's symmetry is only recovered in simulations where the sample is rotated, as opposed to the scanning direction changed. All observations are explained by the potential energy landscape of the tip-sample contact, in contrast with nanoscale topographic wrinkles that have been proposed previously as the source of anisotropy. These results demonstrate the importance of the tip-sample contact quality in determining the potential energy landscape and, in turn, friction at the nanoscale
Friction Anisotropy of MoS2: Effect of TipSample Contact Quality
Atomic-scale friction measured for a single asperity sliding on 2D materials depend on the direction of scanning relative to the material's crystal lattice. Here, nanoscale friction anisotropy of wrinkle-free bulk and monolayer MoS2 is characterized using atomic force microscopy and molecular dynamics simulations. Both techniques show 180° periodicity (2-fold symmetry) of atomic-lattice stick-slip friction vs. the tip's scanning direction with respect to the MoS2 surface. The 60° periodicity (6-fold symmetry) expected from the MoS2 surface's symmetry is only recovered in simulations where the sample is rotated, as opposed to the scanning direction changed. All observations are explained by the potential energy landscape of the tip-sample contact, in contrast with nanoscale topographic wrinkles that have been proposed previously as the source of anisotropy. These results demonstrate the importance of the tip-sample contact quality in determining the potential energy landscape and, in turn, friction at the nanoscale
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Nanoscale Friction Behavior of Transition-Metal Dichalcogenides: Role of the Chalcogenide.
Despite extensive research on the tribological properties of MoS2, the frictional characteristics of other members of the transition-metal dichalcogenide (TMD) family have remained relatively unexplored. To understand the effect of the chalcogen on the tribological behavior of these materials and gain broader general insights into the factors controlling friction at the nanoscale, we compared the friction force behavior for a nanoscale single asperity sliding on MoS2, MoSe2, and MoTe2 in both bulk and monolayer forms through a combination of atomic force microscopy experiments and molecular dynamics simulations. Experiments and simulations showed that, under otherwise identical conditions, MoS2 has the highest friction among these materials and MoTe2 has the lowest. Simulations complemented by theoretical analysis based on the Prandtl-Tomlinson model revealed that the observed friction contrast between the TMDs was attributable to their lattice constants, which differed depending on the chalcogen. While the corrugation amplitudes of the energy landscapes are similar for all three materials, larger lattice constants permit the tip to slide more easily across correspondingly wider saddle points in the potential energy landscape. These results emphasize the critical role of the lattice constant, which can be the determining factor for frictional behavior at the nanoscale
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Nanoscale Friction Behavior of Transition-Metal Dichalcogenides: Role of the Chalcogenide.
Despite extensive research on the tribological properties of MoS2, the frictional characteristics of other members of the transition-metal dichalcogenide (TMD) family have remained relatively unexplored. To understand the effect of the chalcogen on the tribological behavior of these materials and gain broader general insights into the factors controlling friction at the nanoscale, we compared the friction force behavior for a nanoscale single asperity sliding on MoS2, MoSe2, and MoTe2 in both bulk and monolayer forms through a combination of atomic force microscopy experiments and molecular dynamics simulations. Experiments and simulations showed that, under otherwise identical conditions, MoS2 has the highest friction among these materials and MoTe2 has the lowest. Simulations complemented by theoretical analysis based on the Prandtl-Tomlinson model revealed that the observed friction contrast between the TMDs was attributable to their lattice constants, which differed depending on the chalcogen. While the corrugation amplitudes of the energy landscapes are similar for all three materials, larger lattice constants permit the tip to slide more easily across correspondingly wider saddle points in the potential energy landscape. These results emphasize the critical role of the lattice constant, which can be the determining factor for frictional behavior at the nanoscale