The Archaeology of Iran from the Palaeolithic to the Achaemenid Empire

The Archaeology of Iran from the Palaeolithic to the Archaemenid Empire is the first modern academic study to provide a synthetic, diachronic analysis of the archaeology and early history of all of Iran from the Palaeolithic period to the end of the Achaemenid Empire at 330 BC. Drawing on the authors’ deep experience and engagement in the world of Iranian archaeology, and in particular on Iran-based academic networks and collaborations, this book situates the archaeological evidence from Iran within a framework of issues and debates of relevance today. Such topics include human–environment interactions, climate change and societal fragility, the challenges of urban living, individual and social identity, gender roles and status, the development of technology and craft specialisation and the significance of early bureaucratic practices such as counting, writing and sealing within the context of evolving societal formations. Richly adorned with more than 500 illustrations, many of them in colour, and accompanied by a bibliography with more than 3000 entries, this book will be appreciated as a major research resource for anyone concerned to learn more about the role of ancient Iran in shaping the modern world

The absolute chronology of East Chia Sabz: a Pre-Pottery Neolithic site in Western Iran

East Chia Sabz is a PPN site located in the Seimareh Valley, western Iran. 14C dating results indicated that the site was occupied from the early 9th millennium to the early 7th millennium BC. As we have very little information about early Neolithic sites in Iran in comparison with the other regions of the Near and Middle East, the site of East Chia Sabz will provide a new benchmark for investigating the Neolithisation process in Iran. It is important to note that further investigation of Chia Sabz will certainly provide more secure information about how and when the Epipaleolithic transition to the Neolithic started in the region. This paper will present the recent excavations at the site, and then, based on the 14C dates, will discuss the site’s importance in western Iran.Vzhodni Chia Sabz je najdišče, ki je locirano v dolini Seimareh v zahodnem Iranu in datira v obdobje predkeramičnega neolitika. Rezultati radiokarbonskih datacij so pokazali, da je bilo najdišče poseljeno od začetka 9. do začetka 7. tisočletja pr.n.št. Glede na to, da imamo le malo podatkov o zgodnjeneolitskih najdiščih v Iranu v primerjavi z drugimi regijami na Bližnjem in Srednjem vzhodu, bo najdišče Vzhodni Chia Sabz postavilo nova merila za preiskovanje procesa neolitizacije v Iranu. Opozarjamo, da bodo nadaljnje preiskave najdišča Chia Sabz ponudile bolj zanesljive podatke o tem, kako in kdaj se je začel prehod iz epipaleolitika v neolitik v tej regiji. V članku predstavljamo nedavna izkopavanja na najdišču in razpravljamo o pomenu najdišča v zahodnem Iranu na podlagi radiokarbonskih datumov

Variables contextuales en el éxito de las aplicaciones multimedia en la universidad

Use of multimedia technology in classroom is, in some contexts, highly fashionable. There are different myths about this question, like the security of these techonologies enhances learning. On the other hand, research designs used count usually on some methodological unsuitables. One neglected aspect is effect of student satisfaction from classroom process in some dependent variables. In this paper both satisfaction level or degree of pleasantness are measured as for a student group from high school. Procedured used are blackboard, video and computer images animation. Results shows that technology used has effects in pleasantness perceived in classroom. However, authors attract attention about possible temporariness of relations found: they are dependent of context

Designing an Architectural Model of Crisis Management Information System for Natural Disasters in Iran

Introduction: The crisis management information system (CMIS) is a mission-critical system that enables the crisis management team for understanding, diagnosing, interpreting, analyzing, structuring, and making decisions faster by providing timely and high-quality information at the right time. The purpose of this research is to provide an architectural model of a CMIS for managing natural disasters in the process of finding trapped victims and relieving them. Materials and Methods: This applied study was conducted in 2020 in two stages. First, data on CMIS used in selected countries were collected from electronic resources and digital libraries and were then analyzed. Next, a preliminary model of CMIS architecture including three aspects of informational content, applications, and technological requirements, was prepared using these systems and experts’ interviews. Finally, the architectural model of CMIS validated by the Delphi technique and the focus group. Results: The analysis of experts in three rounds of Delphi test for three aspects of informational content, applications and technological requirements in the architectural model was performed with the presence of experts at the national level and the consensus rate over 75% was obtained for 7 modules and 28 proposed components of the CMIS. Conclusion: The architecture of information systems has a direct impact on the performance of these systems. Using an appropriate architecture for CMIS can be an effective step towards reducing the costs and consequences of crises in Iran and countries with similar conditions and have a significant impact on saving human lives in emergency situations

Contractual Justice Toward Corporate Crimes in Pre Trial Stage in Legal System of Iran and United States

Corporate crime as a new form of white-collar crime, has today become one of the challenges of the world's criminal justice systems. Therefore, consensual justice is a new criminal policy that is introduced by some legal systems for such crimes. In this article, with a descriptive-analytical method, we seek to find the answer to the question that in the corporate crimes, as long as the case has not been removed from the pre-trial process, to what extent consensual mechanisms have been recognized in the criminal justice system of Iran and the United States of America? The adopted model of each legal system in the matter of criminal prosecution is a decisive criterion that makes the answer to the question easier. Based on the research findings, in the legal system of the United States, principle of appropriateness of the criminal prosecution has been accepted as a rule, and this principle has also been emphasized under the document of the "principles of federal prosecution of business organization", and thus, in this regard, several consensual institution have been set in this law toward to the majority of corporate crimes. In Iran, based on principle of the necessity of criminal prosecution, some consensual institutions in the form of Alternatives to Criminal Prosecution have been accepted by the legislator in a narrow and limited way within the framework of the Criminal Procedure Law, which is necessary to solve the existing judicial and legal gaps in this regard according the criminal justice system of advanced countries

The early adoption of East Asian crops in West Asia: rice and broomcorn millet in northern Iran

Following their early domestication, broomcorn millet and rice (in East Asia) and wheat and barley (in South-west Asia) were subsequently adopted across Eurasia during the Bronze Age/early historic period. The precise timing and dispersal routes for this trans-Eurasian exchange, however, remain unclear. Here, the authors present archaeobotanical evidence from sites on the Caspian Sea's southern coast, demonstrating that broomcorn millet reached West Asia by c. 2050 BC and rice by c. 120 BC. These dispersals relate to two waves of globalisation and were based on two different mechanisms: an ‘infiltration’ model (broomcorn millet) and a ‘leapfrog’ model (rice). The results contribute to our understanding of the continental-scale connectivity of the late prehistoric/early historic periods

Protection of mice by a λ-based therapeutic vaccine against cancer associated with human papillomavirus type 16

Objective: Human papillomavirus (HPV) oncoproteins (i.e. E6 and E7) are constitutively expressed in cervical cancer cells. The proteins are ideal targets to be used for developing therapeutic vaccines against existing HPV-associated carcinomas. To date, whole bacteriophage ('phage')-λ particles, rather than purified 'naked' DNA, have been described as highly efficient delivery vehicles for a DNA vaccine. Methods: In this study, a safe and efficient λ-based therapeutic cancer vaccine, recombinant λ-ZAP E7 phage, was developed by inserting a HPV16 E7 gene into the Lambda ZAP® cytomegalovirus vector. λ-ZAP E7 phages were employed to immunize mice against the E7-expressing murine tumor cell line (TC-1), which is used as a tumor model in an H-2b murine system. Results: The tumor-bearing mice indicated a significant inhibition of tumor growth after 3 injections of 2 × 1012 particles of recombinant phages. Released lactate dehydrogenase, interferon-γ and granzyme B from spleen cells and lymphocyte proliferation of spleen cells, which all demonstrate the enhancement of cell-mediated immunity, suggested the phages could be a potent gene delivery system in animal models. Conclusion: Our results suggest the recombinant phages can be used as effective biological tools for inducing E7-specific protective immune responses. Hence, the study introduces a possible therapeutic strategy against cervical cancer and other HPV-related neoplasia. Copyright © 2010 S. Karger AG, Basel

The Epipalaeolithic–Neolithic transition in north-eastern Iran: zooarchaeological evidence from the southern shores of the Caspian Sea

In Iran, studies of the transition from hunting and gathering to farming and herding have focused on early developments in the Zagros Mountains. Here, the authors present new zooarchaeological data from Hotu Cave, which throw light on sheep/goat management and domestication during the Epipalaeolithic– Neolithic transition on the southern shores of the Caspian Sea. Gazelle dominate the Epipalaeolithic levels, while sheep/goat are most abundant in the Neolithic. Large quantities of perinatal sheep/goat remains from the Early Neolithic indicate that these animals were actively managed in or close to the cave. The results point towards the importance in Iran of local developments beyond the Zagros, adding nuance to the general model of domestication in South-west Asia

The effect of preoperative aspirin use on postoperative bleeding and perioperative myocardial infarction in patients undergoing coronary artery bypass surgery

Background: We tried to evaluate the clinical outcomes (mortality, postoperative bleeding and perioperative myocardial infarction) of patients who underwent first elective coronary artery bypass grafting and received aspirin during the preoperative period. Methods: The study was a prospective, randomized and single-blinded clinical trial. Two hundred patients were included and divided into two groups. One group received aspirin 80-160 mg, while in the other aspirin was stopped at least seven days before surgery. The primary end-points of the study were in-hospital mortality and hemorrhage-related complications (postoperative blood loss in the intensive care unit, re-exploration for bleeding and red blood cell and non-red blood cell requirements). The secondary end-point was perioperative myocardial infarction. Results: There were no differences in patient characteristics between the aspirin users and non-aspirin users. We found a significant difference between postoperative blood loss (608 ± 359.7 ml vs. 483 ± 251.5 ml; p = 0.005) and red blood cell product requirements (1.32 ± 0.97 unit packed cell vs. 0.94 ± 1.02 unit packed cell; p = 0.008). There was no significant difference between the two groups regarding platelet requirement and the rate of in-hospital mortality and re-exploration for bleeding. Similarly, we found no significant difference in the incidence of definite and probable perioperative myocardial infarction (p = 0.24 and p = 0.56 respectively) or in-hospital mortality between the two groups. Conclusion: Preoperative aspirin administration increased postoperative bleeding and red blood cell requirements with no effect on mortality, re-exploration rate and perioperative myocardial infarction. We recommend withdrawal of aspirin seven days prior to surgery. (Cardiol J 2007; 14: 453-457

Evidence of metabolic mechanisms playing a role in multiple insecticides resistance in Anopheles stephensi populations from Afghanistan.

Background Malaria is endemic in most parts of Afghanistan and insecticide-based vector control measures are central in controlling the disease. Insecticide resistance in the main malaria vector Anopheles stephensi from Afghanistan is increasing and attempts should be made to determine the underlying resistance mechanisms for its adequate management. Methods The contents of cytochrome P450s, esterases, glutathione S-transferases (GSTs) and acetylcholine esterase (AChE) activities were measured in the Kunar and Nangarhar populations of An. stephensi from Afghanistan and the results were compared with those of the susceptible Beech strain using the World Health Organization approved biochemical assay methods for adult mosquitoes. Results The cytochrome P450s enzyme ratios were 2.23- and 2.54-fold in the Kunar and Nangarhar populations compared with the susceptible Beech strain. The enzyme ratios for esterases with alpha-naphthyl acetate were 1.45 and 2.11 and with beta-naphthyl acetate were 1.62 and 1.85 in the Kunar and Nangarhar populations respectively compared with the susceptible Beech strain. Esterase ratios with para-nitrophenyl acetate (pNPA) were 1.61 and 1.75 in the Kunar and Nangarhar populations compared with the susceptible Beech strain. The GSTs enzyme ratios were 1.33 and 1.8 in the Kunar and Nangarhar populations compared with the susceptible Beech strain. The inhibition of AChE was 70.9 in the susceptible Beech strain, and 56.7 and 51.5 in the Kunar and Nangarhar populations. The differences between all values of the enzymes activities/contents and AChE inhibition rates in the Kunar and Nangarhar populations were statistically significant when compared with those of the susceptible Beech strain. Conclusions Based on the results, the reported resistance to pyrethroid and organophosphate insecticides, and tolerance to bendiocarb in the Kunar and Nangarhar populations of An. stephensi from Afghanistan are likely to be caused by a range of metabolic mechanisms, including esterases, P450s and GSTs combined with target site insensitivity in AChE