Being, doing, and play: A theoretical and clinical exploration

This paper explores the metonymy of the following aphorism, delivered by Winnicott in a 1967 lecture: “From being comes doing, but there can be no do before be.” (1970, p. 25, emphasis in original). This aphorism has been little discussed or explored in the literature, but Winnicott articulated similar ideas in his more academic papers (e.g., 1965, 1970). These similar communications about being and doing will be examined alongside more contemporary thinking about the ideas to which Winnicott alludes in this aphorism; works by Benjamin (1988) and Akhtar (2000) in particular will be brought to bear on the subject. Two case studies will then be discussed, in order to examine the clinical implications of the theoretical discussion. Ultimately, such exploration will substantiate the claim that, through the metonymy of being and doing, Winnicott was alluding to a “statement of human nature” that he published just 3 years later (1970, p. 2). Winnicott’s own concept of play will then be posited as a critical, third element comprising “the life of a human being,” which will serve to situate the discussion within a contemporary, relational framework (1970, p. 2)

Changes in epithelial secretory cells and potentiation of neurogenic inflammation in the trachea of rats with respiratory tract infections.

In rats respiratory tract infections due to Sendai virus and coronavirus usually are transient, but they can have long-lasting consequences when accompanied by Mycoplasma pulmonis infections. Morphological alterations in the tracheal epithelium and a potentiation of the inflammatory response evoked by sensory nerve stimulation ("neurogenic inflammation") are evident nine weeks after the infections begin, but the extent to which these changes are present at earlier times is not known. In the present study we characterized these abnormalities in the epithelium and determined the extent to which they are present 3 and 6 weeks after the infections begin. We also determined the magnitude of the potentiation of neurogenic inflammation at these times, whether the potentiation can be reversed by glucocorticoids, and whether a proliferation of blood vessels contributes to the abnormally large amount of plasma extravasation associated with this potentiation. To this end, we studied Long-Evans rats that acquired these viral and mycoplasmal infections from other rats. We found that the tracheal epithelium of the infected rats had ten times as many Alcian blue-PAS positive mucous cells as did that of pathogen-free rats; but it contained none of the serous cells typical of pathogen-free rats, so the total number of secretory cells was not increased. In addition, the epithelium of the infected rats had three times the number of ciliated cells and had only a third of the number of globule leukocytes. In response to an injection of capsaicin (150 micrograms/kg i.v.), the tracheas of the infected rats developed an abnormally large amount of extravasation of two tracers, Evans blue dye and Monastral blue pigment, and had an abnormally large number of Monastral blue-labeled venules, particularly in regions of mucosa overlying the cartilaginous rings. This abnormally large amount of extravasation was blocked by dexamethasone (1 mg/day i.p. for 5 days). We conclude that M. pulmonis infections, exacerbated at the outset by viral infections, result within three weeks in the transformation of epithelial serous cells into mucous cells, the proliferation of ciliated cells, and the depletion of globule leukocytes. They also cause a proliferation of mediator-sensitive blood vessels in the airway mucosa, which is likely to contribute to the potentiation of neurogenic inflammation that accompanies these infections

The Spin Distribution of Fast Spinning Neutron Stars in Low Mass X-Ray Binaries: Evidence for Two Sub-Populations

We study the current sample of rapidly rotating neutron stars in both accreting and non-accreting binaries in order to determine whether the spin distribution of accreting neutron stars in low-mass X-ray binaries can be reconciled with current accretion torque models. We perform a statistical analysis of the spin distributions and show that there is evidence for two sub-populations among low-mass X-ray binaries, one at relatively low spin frequency, with an average of ~300 Hz and a broad spread, and a peaked population at higher frequency with average spin frequency of ~575 Hz. We show that the two sub-populations are separated by a cut-point at a frequency of ~540 Hz. We also show that the spin frequency of radio millisecond pulsars does not follow a log-normal distribution and shows no evidence for the existence of distinct sub-populations. We discuss the uncertainties of different accretion models and speculate that either the accreting neutron star cut-point marks the onset of gravitational waves as an efficient mechanism to remove angular momentum or some of the neutron stars in the fast sub-population do not evolve into radio millisecond pulsars.Comment: Submitted to Ap

Dynamical mean-filed approximation to small-world networks of spiking neurons: From local to global, and/or from regular to random couplings

By extending a dynamical mean-field approximation (DMA) previously proposed by the author [H. Hasegawa, Phys. Rev. E {\bf 67}, 41903 (2003)], we have developed a semianalytical theory which takes into account a wide range of couplings in a small-world network. Our network consists of noisy $N$-unit FitzHugh-Nagumo (FN) neurons with couplings whose average coordination number $Z$ may change from local ($Z \ll N$) to global couplings ($Z=N-1$) and/or whose concentration of random couplings $p$ is allowed to vary from regular ($p=0$) to completely random (p=1). We have taken into account three kinds of spatial correlations: the on-site correlation, the correlation for a coupled pair and that for a pair without direct couplings. The original $2 N$-dimensional {\it stochastic} differential equations are transformed to 13-dimensional {\it deterministic} differential equations expressed in terms of means, variances and covariances of state variables. The synchronization ratio and the firing-time precision for an applied single spike have been discussed as functions of $Z$ and $p$. Our calculations have shown that with increasing $p$, the synchronization is {\it worse} because of increased heterogeneous couplings, although the average network distance becomes shorter. Results calculated by out theory are in good agreement with those by direct simulations.Comment: 19 pages, 2 figures: accepted in Phys. Rev. E with minor change