Informing, teaching or propagandising? Combining Environmental and Science Studies for undergraduates

This article discusses experiences in the integrated teaching of Environmental Studies and Science Studies in a generalist curriculum at a university campus in Scotland. At the University of Glasgow Crichton Campus, a mixed curriculum has been developed to combine coherently Environmental and Science Studies, perhaps the first such curriculum in the UK and equally uncommon in America. The Crichton curricum is intentionally multi-disciplinary, drawing closely on the successful nineteenth-century Scottish model exported to America. This generalist approach, emphasising broad philosophical principles, informs the courses and their inter-relationships

Tuned high-frequency transitor power amplifiers and frequency multipliers

Imperial Users onl

Tendering for low cost generics in Australia

An Australian federal government committee recently proposed, as a cost-saving measure, the introduction of sealed-bid competitive tendering to exclusively supply the Pharmaceutical Benefits Scheme with specific generic medicines. A similar plan involved an open tender to supply generic products below a government set price, also linked with a reduced patient co-payment as an incentive. These proposals represented an opportunity to encourage the price of generic pharmaceuticals to move closer to the marginal cost of production&mdash;a process that could be subsequently applied to innovative (or brand-name) patented medicines in a therapeutic class with many competitors. This article examines these tendering proposals, particularly in relation to the potential for increased involvement of generic pharmaceutical manufacturers in the Australian market.<br /

Temperature variation of raman spectrum of sodium chlorate

Call number: LD2668 .T4 1969 J64Master of Scienc

On the reliability of polarization estimation using Rotation Measure Synthesis

We benchmark the reliability of the Rotation Measure (RM) synthesis algorithm using the 1005 Centaurus A field sources of Feain et al. (2009). The RM synthesis solutions are compared with estimates of the polarization parameters using traditional methods. This analysis provides verification of the reliability of RM synthesis estimates. We show that estimates of the polarization parameters can be made at lower S/N if the range of RMs is bounded, but reliable estimates of individual sources with unusual RMs require unconstrainted solutions and higher S/N. We derive from first principles the statistical properties of the polarization amplitude associated with RM synthesis in the presence of noise. The amplitude distribution depends explicitly on the amplitude of the underlying (intrinsic) polarization signal. Hence it is necessary to model the underlying polarization signal distribution in order to estimate the reliability and errors in polarization parameter estimates. We introduce a Bayesian method to derive the distribution of intrinsic amplitudes based on the distribution of measured amplitudes. The theoretically-derived distribution is compared with the empirical data to provide quantitative estimates of the probability that an RM synthesis solution is correct as a function of S/N. We provide quantitative estimates of the probability that any given RM synthesis solution is correct as a function of measured polarized amplitude and the intrinsic polarization amplitude compared to the noise.Comment: accepted for publication in the Astrophysical Journa

The effect of food and concurrent chemotherapy on the bioavailability of oral etoposide.

There is no information on the effect of food or concurrent drug administration on the bioavailability of oral etoposide, despite the fact that treatment is frequently administered over several days and most often in combination with other cytotoxic agents. The influence of these factors has been studied in 11 patients, receiving combination cytotoxic therapy for extensive small cell lung carcinoma. Neither food nor concurrent oral or intravenous chemotherapy had a significant effect on the mean plasma concentrations of etoposide, achieved following oral administration. Wide variation in peak plasma concentrations and in area under the concentration time curve (AUC) occurred both between and within patients. It appears unnecessary for patients receiving etoposide (at 100 mg) to fast prior to drug administration. Furthermore, oral etoposide (at 100 mg and at 400 mg) may be given in combination with other cytotoxic agents without compromising its bioavailability

Preliminary effectiveness of a smartphone app to reduce depressive symptoms in the workplace: feasibility and acceptability study

© Mark Deady, David Johnston, David Milne, Nick Glozier, Dorian Peters, Rafael Calvo, Samuel Harvey. Background: The workplace represents a unique setting for mental health interventions. Due to range of job-related factors, employees in male-dominated industries are at an elevated risk. However, these at-risk groups are often overlooked. HeadGear is a smartphone app–based intervention designed to reduce depressive symptoms and increase well-being in these populations. Objective: This paper presents the development and pilot testing of the app’s usability, acceptability, feasibility, and preliminary effectiveness. Methods: The development process took place from January 2016 to August 2017. Participants for prototype testing (n=21; stage 1) were recruited from industry partner organizations to assess acceptability and utility. A 5-week effectiveness and feasibility pilot study (n=84; stage 2) was then undertaken, utilizing social media recruitment. Demographic data, acceptability and utility questionnaires, depression (Patient Health Questionnaire-9), and other mental health measures were collected. Results: The majority of respondents felt HeadGear was easy to use (92%), easily understood (92%), were satisfied with the app (67%), and would recommend it to a friend (75%; stage 1). Stage 2 found that compared with baseline, depression and anxiety symptoms were significantly lower at follow-up (t30=2.53; P=.02 and t30=2.18; P=.04, respectively), days of sick leave in past month (t28=2.38; P=.02), and higher self-reported job performance (t28=−2.09; P=.046; stage 2). Over 90% of respondents claimed it helped improve their mental fitness, and user feedback was again positive. Attrition was high across the stages. Conclusions: Overall, HeadGear was well received, and preliminary findings indicate it may provide an innovative new platform for improving mental health outcomes. Unfortunately, attrition was a significant issue, and findings should be interpreted with caution. The next stage of evaluation will be a randomized controlled trial. If found to be efficacious, the app has the potential to reduce disease burden and improve health in this at-risk group