A Q-methodology study of parental understandings of infant immunisation : implications for health-care advice.

This study used Q-methodology to explore systematically parental judgements about infant immunisation. A total of 45 parents completed a 31-statement Q-sort. Data were collected after vaccination in general practitioner practices or a private day nursery. Q factor analysis revealed four distinct viewpoints: a duty to immunise based on medical benefits, child-orientated protection based on parental belief, concern and distress and surprise at non-compliance. Additionally, there was a common view among parents that they did not regret immunising their children. Implications of these results are discussed in terms of health-care policy and future research

Synergies between processing and memory in children's reading span.

Previous research has established the relevance of working memory for cognitive development. Yet the factors responsible for shaping performance in the complex span tasks used to assess working memory capacity are not fully understood. We report a study of reading span in 7- to 11-year old children that addresses several contemporary theoretical issues. We demonstrate that both the timing and the accuracy of recall are affected by the presence or absence of a semantic connection between the processing requirement and the memoranda. Evidence that there can be synergies between processing and memory argues against the view that complex span simply measures the competition between these activities. We also demonstrate a consistent relationship between the rate of completing processing operations (sentence reading) and recall accuracy. At the same time, the shape and strength of this function varies with the task configuration. Taken together, these results demonstrate the potential for reconstructive influences to shape working memory performance among children

Carry on winning: The gamblers' fallacy creates hot hand effects in online gambling.

People suffering from the hot-hand fallacy unreasonably expect winning streaks to continue whereas those suffering from the gamblers' fallacy unreasonably expect losing streaks to reverse. We took 565,915 sports bets made by 776 online gamblers in 2010 and analyzed all winning and losing streaks up to a maximum length of six. People who won were more likely to win again (apparently because they chose safer odds than before) whereas those who lost were more likely to lose again (apparently because they chose riskier odds than before). However, selection of safer odds after winning and riskier ones after losing indicates that online sports gamblers expected their luck to reverse: they suffered from the gamblers' fallacy. By believing in the gamblers' fallacy, they created their own hot hands

Comparison of dermal and inhalation routes of entry for organic chemicals

The quantitative comparison of the chemical concentration inside the body as the result of a dermal exposure versus an inhalation exposure is useful for assessing human health risks and deciding on an appropriate protective posture. In order to describe the relationship between dermal and inhalation routes of exposure, a variety of organic chemicals were evaluated. The types of chemicals chosen for the study were halogenated hydrocarbons, aromatic compounds, non-polar hydrocarbons and inhalation anesthetics. Both dermal and inhalation exposures were conducted in rats and the chemicals were in the form of vapors. Prior to the dermal exposure, rat fur was closely clipped and during the exposure rats were provided fresh breathing air through latex masks. Blood samples were taken during 4-hour exposures and analyzed for the chemical of interest. A physiologically based pharmacokinetic model was used to predict permeability constants (cm/hr) consistent with the observed blood concentrations of the chemical. The ratio of dermal exposure to inhalation exposure required to achieve the same internal dose of chemical was calculated for each test chemical. The calculated ratio in humans ranged from 18 for styrene to 1180 for isoflurane. This methodology can be used to estimate the dermal exposure required to reach the internal dose achieved by a specific inhalation exposure. Such extrapolation is important since allowable exposure standards are often set for inhalation exposures, but occupational exposures may be dermal

MAGMO: Coherent magnetic fields in the star forming regions of the Carina-Sagittarius spiral arm tangent

We present the pilot results of the `MAGMO' project, targeted observations of ground-state hydroxyl masers towards sites of 6.7-GHz methanol maser emission in the Carina-Sagittarius spiral arm tangent, Galactic longitudes 280 degrees to 295 degrees. The `MAGMO' project aims to determine if Galactic magnetic fields can be traced with Zeeman splitting of masers associated with star formation. Pilot observations of 23 sites of methanol maser emission were made, with the detection of ground-state hydroxyl masers towards 11 of these and six additional offset sites. Of these 17 sites, nine are new detections of sites of 1665-MHz maser emission, three of them accompanied by 1667-MHz emission. More than 70% of the maser features have significant circular polarization, whilst only ~10% have significant linear polarization (although some features with up to 100% linear polarization are found). We find 11 Zeeman pairs across six sites of high-mass star formation with implied magnetic field strengths between -1.5 mG and +3.8 mG and a median field strength of +1.6 mG. Our measurements of Zeeman splitting imply that a coherent field orientation is experienced by the maser sites across a distance of 5.3+/-2.0 kpc within the Carina-Sagittarius spiral arm tangent.Comment: 19 pages, 13 figures, accepted for publication in MNRA

A parallel multistate framework for atomistic non-equilibrium reaction dynamics of solutes in strongly interacting organic solvents

We describe a parallel linear-scaling computational framework developed to implement arbitrarily large multi-state empirical valence bond (MS-EVB) calculations within CHARMM. Forces are obtained using the Hellman-Feynmann relationship, giving continuous gradients, and excellent energy conservation. Utilizing multi-dimensional Gaussian coupling elements fit to CCSD(T)-F12 electronic structure theory, we built a 64-state MS-EVB model designed to study the F + CD3CN -> DF + CD2CN reaction in CD3CN solvent. This approach allows us to build a reactive potential energy surface (PES) whose balanced accuracy and efficiency considerably surpass what we could achieve otherwise. We use our PES to run MD simulations, and examine a range of transient observables which follow in the wake of reaction, including transient spectra of the DF vibrational band, time dependent profiles of vibrationally excited DF in CD3CN solvent, and relaxation rates for energy flow from DF into the solvent, all of which agree well with experimental observations. Immediately following deuterium abstraction, the nascent DF is in a non-equilibrium regime in two different respects: (1) it is highly excited, with ~23 kcal mol-1 localized in the stretch; and (2) not yet Hydrogen bonded to the CD3CN solvent, its microsolvation environment is intermediate between the non-interacting gas-phase limit and the solution-phase equilibrium limit. Vibrational relaxation of the nascent DF results in a spectral blue shift, while relaxation of its microsolvation environment results in a red shift. These two competing effects result in a post-reaction relaxation profile distinct from that observed when DF vibration excitation occurs within an equilibrium microsolvation environment. The parallel software framework presented in this paper should be more broadly applicable to a range of complex reactive systems.Comment: 58 pages and 29 Figure