A PRÁTICA DO KENDÔ NA UNIVERSIDADE: UM RELATO DE EXPERIÊNCIA

Kendo is a Japanese martial art that has been spreading in the Western world. With features similar to fencing, it provides combat between two opponents in which the objective is to strike your opponent with a bamboo sword, in specific places that are protected by armor. The university environment, in addition to being a space for the production and exchange of academic and scientific knowledge, is also a place for professional and personal training. In this sense, we understand that formation is a broad process that involves different human dimensions, which at the University are developed in activities with different characteristics: in classrooms, in field classes, in laboratories, in student bodies, in involvement in projects (artistic, cultural and sports, for example), among others. This experience report aims to describe actions taken to develop a project aimed at beginners in the university environment, as well as share some challenges encountered throughout this endeavor. The project was developed at the School of Arts, Sciences and Humanities of the University of São Paulo, in different formats in the various editions held between 2015 and 2019. It had the participation of people from the internal and external community and promoted exchanges between subscribers and practitioners from other locations. The challenges that stood out the most, observing the period considered, were the provision of the necessary equipment for the practice and the heterogeneity of the classes regarding the level of practice.El Kendo es un arte marcial japonesa que ha ido ganando terreno en el mundo occidental. Con características similares a la esgrima, brinda combate entre dos oponentes en el que el objetivo es golpear a tu oponente con una espada de bambú, en lugares específicos y protegido por una armadura. El contexto universitario, además de ser un espacio de producción e intercambio de conocimientos académicos y científicos, es también un lugar de formación profesional y personal. En este sentido, entendemos la formación como un proceso amplio que involucra diferentes dimensiones humanas, que en la Universidad se desarrollan en actividades con distintas características: en las aulas, en las clases de campo, en los laboratorios, en los cuerpos de estudiantes, en la implicación en proyectos (artísticos, culturales y deportivos, por ejemplo), entre otros. Este relato de experiencia tiene como objetivo describir las acciones tomadas para desarrollar un proyecto dirigido a principiantes en el ámbito universitario, así como compartir algunos desafíos encontrados a lo largo de este esfuerzo. El proyecto en cuestión fue desarrollado en la Facultad de Artes, Ciencias y Humanidades de la Universidad de São Paulo, en diferentes formatos en las distintas ediciones realizadas entre 2015 y 2019. Contó con la participación de personas de la comunidad interna y externa y promovió intercambios entre suscriptores y profesionales de otros lugares. Los desafíos que más se destacaron, observando el período observado, fueron la dotación del equipamiento necesario para la práctica y la heterogeneidad de las clases en cuanto al nivel de práctica.O Kendô é uma arte marcial Japonesa que vem ganhando espaço no mundo ocidental. Com características semelhantes à esgrima, proporciona combates entre dois oponentes nos quais o objetivo é golpear o seu adversário com uma espada de bambu, em locais determinados e protegidos por uma armadura. O ambiente universitário, além de ser um espaço de produção e troca de conhecimento acadêmico e científico, também se constitui como um lugar de formação profissional e pessoal. Nesse sentido, entendemos a formação como um processo amplo e que envolve as diferentes dimensões humanas, que na Universidade se desenvolvem em atividades com características diversas: nas aulas em sala, em aulas de campo, nos laboratórios, nas entidades estudantis, no envolvimento em projetos (artísticos, culturais e esportivos por exemplo), entre outras. O presente relato de experiência tem como objetivo descrever as ações realizadas para o desenvolvimento de um projeto de prática de Kendô voltado para iniciantes no ambiente universitário, bem como compartilhar alguns desafios encontrados ao longo desta empreitada. O projeto em questão foi desenvolvido na Escola de Artes, Ciências e Humanidades da Universidade de São Paulo, em diferentes formatos nas diversas edições ocorridas entre 2015 e 2019. Contou com a participação de pessoas da comunidade interna e externa e promoveu intercâmbios entre os inscritos e praticantes de outras localidades. Os desafios impostos que mais se destacaram, observando-se o período em questão, foram o provimento do equipamento necessário para a prática e a heterogeneidade das turmas, no que diz respeito ao nível de prática. &nbsp

Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ release

© 2019 Denwood et al.Somatostatin secretion from pancreatic islet δ-cells is stimulated by elevated glucose levels, but the underlying mechanisms have only partially been elucidated. Here we show that glucose-induced somatostatin secretion (GISS) involves both membrane potential-dependent and -independent pathways. Although glucose-induced electrical activity triggers somatostatin release, the sugar also stimulates GISS via a cAMP-dependent stimulation of CICR and exocytosis of somatostatin. The latter effect is more quantitatively important and in mouse islets depolarized by 70 mM extracellular K+, increasing glucose from 1 mM to 20 mM produced an ∼3.5-fold stimulation of somatostatin secretion, an effect that was mimicked by the application of the adenylyl cyclase activator forskolin. Inhibiting cAMP-dependent pathways with PKI or ESI-05, which inhibit PKA and exchange protein directly activated by cAMP 2 (Epac2), respectively, reduced glucose/forskolin-induced somatostatin secretion. Ryanodine produced a similar effect that was not additive to that of the PKA or Epac2 inhibitors. Intracellular application of cAMP produced a concentration-dependent stimulation of somatostatin exocytosis and elevation of cytoplasmic Ca2+ ([Ca2+]i). Both effects were inhibited by ESI-05 and thapsigargin (an inhibitor of SERCA). By contrast, inhibition of PKA suppressed δ-cell exocytosis without affecting [Ca2+]i Simultaneous recordings of electrical activity and [Ca2+]i in δ-cells expressing the genetically encoded Ca2+ indicator GCaMP3 revealed that the majority of glucose-induced [Ca2+]i spikes did not correlate with δ-cell electrical activity but instead reflected Ca2+ release from the ER. These spontaneous [Ca2+]i spikes are resistant to PKI but sensitive to ESI-05 or thapsigargin. We propose that cAMP links an increase in plasma glucose to stimulation of somatostatin secretion by promoting CICR, thus evoking exocytosis of somatostatin-containing secretory vesicles in the δ-cell.Peer reviewedFinal Published versio

A Case of Diffuse Alveolar Hemorrhage Associated with Tegafur Plus Uracil and Warfarin Therapy

A 72-year-old man who received warfarin for myocardial infarction (prothrombin time-international normalized ratio [PT-INR] controlled between 2.2 and 2.5) for 2 years. He developed lung cancer, underwent surgery, and received tegafur plus uracil (UFT) after 1 month. After 2 months, he was admitted for hemoptysis and dyspnea. Chest radiography and computed tomography showed bilateral alveolar infiltration (PT-INR, 8.9). Bronchoalveolar lavage fluid (BALF) disclosed hemorrhagic features in sequential samples. And he was diagnosed with diffuse alveolar hemorrhage (DAH). A known interaction exists between fluoropyrimidines and warfarin. So, they were discontinued, and vitamin K was intravenously administered. One day later, the PT-INR returned to 1.14. The symptoms improved and, alveolar infiltration resolved after 2 weeks. Alveolar hemorrhage may be due to an interaction between UFT and warfarin. When fluoropyrimidines and warfarin are prescribed simultaneously, we recommend that PT-INR should be closely monitored

Dosing Rate-Dependent Relationship between Propranolol Plasma Concentration and fl-Blockade1

ABBREVIATIONS: LA, sustained-release of propranolol capsule; PL, conventional propranolol tablet; %R, percentage of reduction of heart rate; HPLC, high-performance liquid chromatography; B ,, maximum binding sites. ABSTRACT The effect of propranolol dosing rat

A Semantic and Pragmatic Approach to CAN

　The paper is concerned with the study of can from a semantic and pragmatic point of view, emphasizing its functions as ability, permission possibility, permission, and request

The association between embedded catheter implantation and hospitalization costs for peritoneal dialysis initiation: a retrospective cohort study

Background: Compared with the conventional peritoneal dialysis (PD) catheter insertion, embedding PD catheter implantation is one of the procedures for planned PD initiation. However, facilities where embedded PD catheter implantation is available are limited, and the impact of embedded PD catheter implantation on hospitalization cost and length of hospitalization is unknown. Methods: This retrospective single-center cohort study included 132 patients with PD initiation between 2005 and 2020. The patients were divided into two groups: 64 patients in the embedding group and 68 patients in the conventional insertion group. We created a multivariable generalized linear model (GLM) with the gamma family and log-link function to evaluate the association among catheter embedding, the duration and medical costs of hospitalization for PD initiation. We also evaluated the effect modification between age and catheter embedding. Results: Catheter embedding (β coefficient − 0.13 [95% confidence interval − 0.21, − 0.05]) and age (per 10 years 0.08 [0.03, 0.14]) were significantly associated with hospitalization costs. Catheter embedding (− 0.21 [− 0.32, − 0.10]) and age (0.11 [0.03, 0.19]) were also identified as factors significantly associated with length of hospitalization. The difference between the embedding group and the conventional insertion group in hospitalization costs for PD initiation (P for interaction = 0.060) and the length of hospitalization (P for interaction = 0.027) was larger in young-to-middle-aged patients than in elderly patients. Conclusions: Catheter embedding was associated with lower hospitalization cost and shorter length of hospitalization for PD initiation than conventional PD catheter insertion, especially in young-to-middle-aged patients.The version of record of this article, first published in Clinical and Experimental Nephrology, is available online at Publisher’s website: https://doi.org/10.1007/s10157-023-02416-

The effects of handling on the sleep of preterm infants

Objective: Identify the types of handling procedures performed on preterm infants and assess their influence on total sleep time, wake time and the objective sleep variables. Methods: Observational and correlational study conducted in the neonatal unit of a teaching hospital. The sample was made up of 12 preterm infants who met the inclusion and exclusion criteria established for the study. Data were collected from March 2013 to April 2014, by means of polysomnography, filming and observation for 24 uninterrupted hours. Descriptive statistics, the Friedman test, Pearson's correlation and linear regression, with significant values of p <= 0.05, were used. Results: The preterm infants studied were predominantly late preterm, female, with low birth weight, and a mean chronological age of 14 days. The newborns were handled an average of 176.4 (+/- 37.9) times during a 24-hour period58% of the handling procedures were for monitoring. The proportion of total sleep time was 57.2% in 24 hours. There was no statistically significant correlation between frequency and duration of direct and ambient handling and the sleep of preterm infants in a 24-hour period. Single handling procedures had a strong positive correlation with wake time. Conclusion: Handling was related to monitoring, therapeutic/diagnostic and hygiene/comfort, with a prevalence of direct, single handling procedures. No statistically significant influence on the objective sleep variables was identified, except for single handling procedures where there was a correlation with wake time.Objetivo: Identificar os tipos das manipulações realizadas em recém-nascidos prematuros e avaliar a influência sobre os tempos totais de sono, vigília e as variáveis objetivas do sono. Métodos: Estudo observacional e de correlação realizado em uma unidade neonatal de hospital universitário. A amostra foi constituída por 12 recém-nascidos prematuros que atenderam aos critérios de inclusão e exclusão estabelecidos para o estudo. Os dados foram coletados no período de março de 2013 à abril de 2014 e obtidos por meio do polissonígrafo, filmagem e observação durante 24 horas, ininterruptas. Utilizou-se a estatística descritiva, teste de Friedman, correlação de Pearson e regressão linear, com valores significantes p<0,05. Resultados: Os prematuros estudados eram predominantemente tardios, do sexo feminino, com baixo peso ao nascer e idade cronológica média de 14 dias. Os neonatos foram manipulados em média 176,4(±37,9) vezes durante as 24 horas, sendo que 58% das manipulações foram para monitoramento. A proporção do tempo total de sono foi 57,2% em 24 horas. Não houve correlação estatisticamente significante entre as frequências e os tempos de duração das manipulações diretas e do ambiente com o sono dos RNPT em 24 horas. A forma única apresentou correlação fortemente positiva com a vigília. Conclusão: As manipulações relacionaram-se ao monitoramento, terapêutica/diagnóstica e cuidados de higiene e conforto, com prevalência das manipulações diretas e únicas, não sendo identificada influência estatisticamente significante sobre as variáveis objetivas do sono, com exceção das manipulações únicas que apresentaram correlação com o tempo de vigília.FAPESP (Sao Paulo Research Foundation)Univ Fed Sao Paulo, Escola Paulista Enfermagem, Sao Paulo, SP, BrazilUniv Estadual Paulista, Inst Biostat, Botucatu, SP, BrazilUniv Fed Sao Paulo, Inst Sono, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Escola Paulista Enfermagem, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Inst Sono, Sao Paulo, SP, BrazilFAPESP: 2012/50365-2Web of Scienc

A Case of Fisher Syndrome Complicated by Maxillary Sinus Cysts

Fisher syndrome (FS) is an autoimmune peripheral neuropathy that occurs in 1 person per 2 million population. The present report is of a patient with FS who presented with diplopia and discomfort of the right cheek and in whom differentiation from maxillary sinus cysts was necessary. The patient was a 43-year-old man with a history of radical surgery of the right maxillary sinus, so we suspected that his symptoms were due to postoperative maxillary sinus cysts. Although computed tomography demonstrated right maxillary sinus cysts, these cysts were not likely to be the cause of the patient\u27s diplopia. Close neurological examination revealed external ophthalmoplegia, cerebellar ataxia, and the absence of a deep tendon reflex; on this basis, a diagnosis of FS was made. Diplopia is caused by various disorders and FS should be taken into consideration when making a differential diagnosis

Formation kinetics of levoglucosan from glucose in high temperature water

金沢大学理工研究域自然システム学系The application of high temperature water to produce levoglucosan from glucose was studied. The reactions were performed using a tube reactor, and the kinetics for the decomposition of glucose and levoglucosan in high temperature water was examined. The temperature dependence of the reaction rate of the glucose decomposition was of the Arrhenius type. In contrast, the reaction rates for the decomposition of levoglucosan decreased with the increasing temperature at the constant pressure of 25 MPa. The yields of levoglucosan were examined in the temperature range from 200 to 410 °C and the pressure from 5 to 25 MPa. It was found that the yields of levoglucosan increased with the decreasing pressure. © 2009 Elsevier B.V. All rights reserved