Equivalent models for gauged WZW theory

We modify the $SL(2,{\bf R})/U(1)$ WZW theory, which was shown to describe strings in a 2D black hole, to be invariant under chiral $U(1)$ gauge symmetry by introducing a Steukelberg field. We impose several interesting gauge conditions for the chiral $U(1)$ symmetry. In a paticular gauge the theory is found to be reduced to the Liouville theory coupled to the $c=1$ matter perturbed by the so-called black hole mass operator. Also we discuss the physical states in the models briefly.Comment: 13pages, KANAZAWA 93-0

Large Mass Scale by Strong Gauge Dynamics with Infrared Fixed Point

We consider a mechanism for realizing the desired decoupling of strongly-coupled sector which is supposed to generate hierarchical structure of the Yukawa couplings. In our mechanism, the same strongly-coupled sector is responsible for generating a sufficiently flat potential and a large vacuum expectation value (VEV) of a gauge-singlet scalar field by suppressing its soft scalar mass and self-coupling. Vacuum instability is caused by supersymmetry-breaking A-term of order 10 TeV. We explicitly demonstrate the infrared convergence of soft scalar masses due to strongly-coupled dynamics and show the soft mass of the singlet is at most comparable to soft masses of squarks and sleptons, which are much suppressed than the A-term. The physical mass scale of the decoupling is calculated in a self-consistent way. We also reinterpret the result in terms of a RG-improved effective potential.Comment: 18 pages, 4 figures, 1 table, LaTeX (PTPTeX style

PrimerStation: a highly specific multiplex genomic PCR primer design server for the human genome

PrimerStation () is a web service that calculates primer sets guaranteeing high specificity against the entire human genome. To achieve high accuracy, we used the hybridization ratio of primers in liquid solution. Calculating the status of sequence hybridization in terms of the stringent hybridization ratio is computationally costly, and no web service checks the entire human genome and returns a highly specific primer set calculated using a precise physicochemical model. To shorten the response time, we precomputed candidates for specific primers using a massively parallel computer with 100 CPUs (SunFire 15 K) about 3 months in advance. This enables PrimerStation to search and output qualified primers interactively. PrimerStation can select highly specific primers suitable for multiplex PCR by seeking a wider temperature range that minimizes the possibility of cross-reaction. It also allows users to add heuristic rules to the primer design, e.g. the exclusion of single nucleotide polymorphisms (SNPs) in primers, the avoidance of poly(A) and CA-repeats in the PCR products, and the elimination of defective primers using the secondary structure prediction. We performed several tests to verify the PCR amplification of randomly selected primers for ChrX, and we confirmed that the primers amplify specific PCR products perfectly

Magnetic field-induced one-magnon Raman scattering in the magnon Bose-Einstein condensation phase of TlCuCl3_{3}

We report the observation of the $A_{\rm g}$-symmetric one-magnon Raman peak in the magnon Bose-Einstein condensation phase of TlCuCl$_{3}$. Its Raman shift traces the one-magnon energy at the magnetic $\Gamma$ point, and its intensity is proportional to the squared transverse magnetization. The appearance of the one-magnon Raman scattering originates from the exchange magnon Raman process and reflects the change of the magnetic-state symmetry. Using the bond-operator representation, we theoretically clarify the Raman selection rules, being consistent with the experimental results.Comment: 6 pages, 4 figure

DEVELOPMENT OF A TABLE TENNIS MACHINE TO COUNTER THE “CHIQUITA” SPIN

After Beijing Olympics, leading athletes began to use a stroke known as the “Chiquita” spin frequently. Thus, the Japan national table tennis team at the time undertook countermeasures against the Chiquita spin including some plans. However, these did not produce significant results. Therefore, we developed a table tennis training machine for the team in activities supporting the Japan national table tennis team. The machine has 3 rotors to shoot a ball stably. Also, these rotors are twisted to make a “gyro rotation” of the ball. This machine was introduced into the Japan national table tennis team to take measures for London 2012 Olympic

Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients

<p>Abstract</p> <p>Background</p> <p>Germline mono-allelic promoter hypermethylation of the <it>MLH1 </it>or <it>MSH2 </it>gene in families with hereditary nonpolyposis colorectal cancer has recently been reported. The purpose of this study was to evaluate if germline promoter hypermethylation of the tumor suppressor gene <it>CDH1 </it>(<it>E-cadherin</it>) might cause predisposition to gastric cancer.</p> <p>Methods</p> <p>We prepared two groups of samples, a group of blood samples from 22 patients with familial gastric cancer or early-onset gastric cancer selected from among 39 patients, and a group of non-cancerous gastric tissue samples from 18 patients with sporadic gastric cancer showing loss of CDH1 expression selected from among 159 patients. We then investigated the allele-specific methylation status of the <it>CDH1 </it>promoter by bisulfite sequencing of multiple clones.</p> <p>Results</p> <p>Although there was a difference between the methylation level of the two alleles in some samples, there was no mono-allelic promoter hypermethylation in any of the samples.</p> <p>Conclusion</p> <p>These results suggest that germline mono-allelic hypermethylation of the <it>CDH1 </it>promoter is not a major predisposing factor for gastric cancer.</p

Quantum Analysis of Jackiw and Teitelboim's Model for 1+1 D Gravity and Topological Gauge Theory

We study the BRST quantization of the 1+1 dimensional gravity model proposed by Jackiw and Teitelboim and also the topological gauge model which is equivalent to the gravity model at least classically. The gravity model quantized in the light-cone gauge is found to be a free theory with a nilpotent BRST charge. We show also that there exist twisted N=2 superconformal algebras in the Jackiw-Teitelboim's model as well as in the topological gauge model. We discuss the quantum equivalence between the gravity theory and the topological gauge theory. It is shown that these theories are indeed equivalent to each other in the light-cone gauge.Comment: 31 page

Stromal micropapillary component as a novel unfavorable prognostic factor of lung adenocarcinoma

<p>Abstract</p> <p>Background</p> <p>Pulmonary adenocarcinomas with a micropapillary component having small papillary tufts and lacking a central fibrovascular core are thought to result in poor prognosis. However, the component consists of tumor cells often floating within alveolar spaces (aerogenous micropapillary component [AMPC]) rather than invading fibrotic stroma observed in other organs like breast (stromal invasive micropapillary component [SMPC]). We previously observed cases of lung adenocarcinoma with predominant SMPC that was associated with micropapillary growth of tumors in fibrotic stroma observed in other organs. We evaluated the incidence and clinicopathological characteristics of SMPC in lung adenocarcinoma cases.</p> <p>Patients and Methods</p> <p>We investigated the clinicopathological characteristics and prognostic significance of SMPC in lung adenocarcinoma cases by reviewing 559 patients who had undergone surgical resection. We examined the SMPC by performing immunohistochemical analysis with 17 antibodies and by genetic analysis with epidermal growth factor receptor (<it>EGFR</it>) and <it>KRAS </it>mutations.</p> <p>Results</p> <p>SMPC-positive (SMPC(+)) tumors were observed in 19 cases (3.4%). The presence of SMPC was significantly associated with tumor size, advanced-stage disease, lymph node metastasis, pleural invasion, lymphatic invasion, and vascular invasion. Patients with SMPC(+) tumors had significantly poorer outcomes than those with SMPC-negative tumors. Multivariate analysis revealed that SMPC was a significant independent prognostic factor of lung adenocarcinoma, especially for disease-free survival of pathological stage I patients (<it>p </it>= 0.035). SMPC showed significantly higher expression of E-cadherin and lower expression of CD44 than the corresponding expression levels shown by AMPC and showed lower surfactant apoprotein A and phospho-c-Met expression level than corresponding expression levels shown by tumor cell components without a micropapillary component. Fourteen cases with SMPC(+) tumors (74%) showed <it>EGFR </it>mutations, and none of them showed <it>KRAS </it>mutations.</p> <p>Conclusions</p> <p>SMPC(+) tumors are rare, but they may be associated with a poor prognosis and have different phenotypic and genotypic characteristics from those of AMPC(+) tumors.</p> <p>Virtual Slides</p> <p>The virtual slide(s) for this article can be found here: <url>http://www.diagnosticpathology.diagnomx.eu/vs/9433341526290040</url>.</p