Annual Report Iowa State University Veterinary Medical Alumni Association

The Board of Directors of the Iowa State University Veterinary Medical Alumni Association met at the Marriot Hotel on Saturday, January 26, 1991. Members present were Wertman, Frey, Feldman, and Hartwig. The attached treasurer\u27s report and 1991 proposed budgetwas reviewed and approved by the board. The auditors report, performed by Drs. Roger Hogle and David Larson was accepted. The Board agreed to pay the cost of sending the secretary to the AVMA meeting in Seattle to sponsor the ISUVMAA receptio

Minutes: ISUVMAA Board Meeting

The meeting was called to order by President Wilgenbusch at 2 p.m. Members present were: Duke Wilgenbusch, Jerry Den Herder, Wendell Davis, Fred Wertman, Jim Sievers, and Nolan Hartwig. A treasurer\u27s report dated 5/26/88 (attached) was presented and accepted. The program for the Stange Banquet (attached) was also reviewed

Annual Meeting Iowa State University Veterinary Medical Alumni Association

The annual meeting was held at the Savery Hotel on January 23, 1994. Thirty-eight members attended. President Feldman called the meeting to order. Secretary/Treasurer Hartwig gave the treasurer\u27s report and presented the proposed budget for 1994. The budget was approved. He also reported on the College of Veterinary Medicine Alumni Association, sponsored alumni receptions at various national meetings during the last year and activites with regard to the ISU Veterinarian. He reported on progess to date on the Frank K. Ramsey Alumni Room Fund Drive. It was noted that approximately $28,000.00 has been raised to date and more will be needed to complete the remodeling and refurbishing. He displayed an artist\u27s drawing of the remodeled room, sample fabrics, and preliminary estimates of costs

Adopt Publication

A note from the Winter 1939 issue of the Veterinary Student, as well as congratulatory notes on the ISU Veterinarian\u27s 50th anniversary from Dean Pearson of the College of Veterinary Medicine, and Nolan Hartwig, Secretary/Treasurer of the Alumni Association

Raising a Small Flock of Sheep in Ohio

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Phospholipase D signaling: orchestration by PIP2 and small GTPases

Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of the versatile lipid second messenger, phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be dramatically stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and, particularly, by the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 is well known as substrate for the generation of second messengers by phospholipase C, but is now also understood to recruit and/or activate a variety of actin regulatory proteins, ion channels and other signaling proteins, including PLD, by direct interaction. The synthesis of PIP2 by phosphoinositide 5-kinase (PIP5K) isoforms is tightly regulated by small GTPases and, interestingly, by PA as well, and the concerted formation of PIP2 and PA has been shown to mediate receptor-regulated cellular events. This review highlights the regulation of PLD by membrane receptors, and describes how the close encounter of PLD and PIP5K isoforms with small GTPases permits the execution of specific cellular functions

Non-AIDS defining cancers in the D:A:D Study-time trends and predictors of survival : a cohort study

BACKGROUND:Non-AIDS defining cancers (NADC) are an important cause of morbidity and mortality in HIV-positive individuals. Using data from a large international cohort of HIV-positive individuals, we described the incidence of NADC from 2004-2010, and described subsequent mortality and predictors of these.METHODS:Individuals were followed from 1st January 2004/enrolment in study, until the earliest of a new NADC, 1st February 2010, death or six months after the patient's last visit. Incidence rates were estimated for each year of follow-up, overall and stratified by gender, age and mode of HIV acquisition. Cumulative risk of mortality following NADC diagnosis was summarised using Kaplan-Meier methods, with follow-up for these analyses from the date of NADC diagnosis until the patient's death, 1st February 2010 or 6 months after the patient's last visit. Factors associated with mortality following NADC diagnosis were identified using multivariable Cox proportional hazards regression.RESULTS:Over 176,775 person-years (PY), 880 (2.1%) patients developed a new NADC (incidence: 4.98/1000PY [95% confidence interval 4.65, 5.31]). Over a third of these patients (327, 37.2%) had died by 1st February 2010. Time trends for lung cancer, anal cancer and Hodgkin's lymphoma were broadly consistent. Kaplan-Meier cumulative mortality estimates at 1, 3 and 5 years after NADC diagnosis were 28.2% [95% CI 25.1-31.2], 42.0% [38.2-45.8] and 47.3% [42.4-52.2], respectively. Significant predictors of poorer survival after diagnosis of NADC were lung cancer (compared to other cancer types), male gender, non-white ethnicity, and smoking status. Later year of diagnosis and higher CD4 count at NADC diagnosis were associated with improved survival. The incidence of NADC remained stable over the period 2004-2010 in this large observational cohort.CONCLUSIONS:The prognosis after diagnosis of NADC, in particular lung cancer and disseminated cancer, is poor but has improved somewhat over time. Modifiable risk factors, such as smoking and low CD4 counts, were associated with mortality following a diagnosis of NADC